Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Susanne Laukoter"'
Autor:
Susanne Laukoter, Robert Beattie, Florian M. Pauler, Nicole Amberg, Keiichi I. Nakayama, Simon Hippenmeyer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
How the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projec
Externí odkaz:
https://doaj.org/article/30a406ce09274ca2817830f81bfa62fe
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100215- (2020)
Summary: Mosaic analysis with double markers (MADM) technology enables concomitant fluorescent cell labeling and induction of uniparental chromosome disomy (UPD) with single-cell resolution. In UPD, imprinted genes are either overexpressed 2-fold or
Externí odkaz:
https://doaj.org/article/936b6a58a3ed4addb9d2dfdc67b27893
Autor:
Andi H. Hansen, Florian M. Pauler, Michael Riedl, Carmen Streicher, Anna Heger, Susanne Laukoter, Christoph Sommer, Armel Nicolas, Björn Hof, Li Huei Tsai, Thomas Rülicke, Simon Hippenmeyer
The mammalian neocortex is composed of diverse neuronal and glial cell classes that broadly arrange in six distinct laminae. Cortical layers emerge during development and defects in the developmental programs that orchestrate cortical lamination are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19809e2c9a5b73c8114943dbb47760d8
https://doi.org/10.1101/2022.02.16.480659
https://doi.org/10.1101/2022.02.16.480659
Publikováno v:
Neurochemistry International
Genomic imprinting is an epigenetic mechanism that results in parental allele-specific expression of ~1% of all genes in mouse and human. Imprinted genes are key developmental regulators and play pivotal roles in many biological processes such as nut
Autor:
Simon Hippenmeyer, Nicole Amberg, Robert Beattie, Florian M. Pauler, Keiichi I. Nakayama, Susanne Laukoter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The cyclin-dependent kinase inhibitor p57KIP2 is encoded by the imprinted Cdkn1c locus, exhibits maternal expression, and is essential for cerebral cortex development. How Cdkn1c regulates corticogenesis is however not clear. To this end we employ Mo
Autor:
Ulrike Köck, Jan Bauer, Hans Lassmann, Etsuji Saji, Anna R. Tröscher, Susanne Laukoter, Kurt A. Jellinger, Helmut Rauschka
Publikováno v:
Acta Neuropathologica
During the appearance of human immunodeficiency virus infection in the 1980 and the 1990s, progressive multifocal leukoencephalopathy (PML), a viral encephalitis induced by the JC virus, was the leading opportunistic brain infection. As a result of t
Publikováno v:
Journal of Neurochemistry
The cerebral cortex is composed of a large variety of distinct cell‐types including projection neurons, interneurons, and glial cells which emerge from distinct neural stem cell lineages. The vast majority of cortical projection neurons and certain
Autor:
Andi H. Hansen, Susanne Laukoter, Nicole Amberg, Thomas Penz, Christoph Bock, Carmen Streicher, Simon Hippenmeyer, Robert Beattie, Florian M. Pauler
Publikováno v:
Neuron
In mammalian genomes, a subset of genes is regulated by genomic imprinting, resulting in silencing of one parental allele. Imprinting is essential for cerebral cortex development, but prevalence and functional impact in individual cells is unclear. H
Autor:
Guanxi Xiao, Laura E. Burnett, Florian M. Pauler, Troy H. Ghashghaei, Susanne Laukoter, Simon Hippenmeyer, Olga Klezovitch, Valeri Vasioukhin, Robert Beattie, Maria Pia Postiglione, Carmen Streicher
Publikováno v:
Neuron. 94(3)
The concerted production of neurons and glia by neural stem cells (NSCs) is essential for neural circuit assembly. In the developing cerebral cortex, radial glia progenitors (RGPs) generate nearly all neocortical neurons and certain glia lineages. RG