Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Susanne Kirschnek"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 9, Pp 1-12 (2024)
Abstract Myeloid cells are the first line of defence against pathogens. Mitochondrial apoptosis signalling is a crucial regulator of myeloid cell lifespan and modulates the function of myeloid cells. The anti-apoptotic protein BCL-2-family protein BC
Externí odkaz:
https://doaj.org/article/93803125dba448e29f9e16077338632d
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Abstract Regulated cell death frequently occurs upon infection by intracellular pathogens, and extent and regulation is often cell-type-specific. We aimed to identify the cell death-signaling pathways triggered in macrophages by infection with modifi
Externí odkaz:
https://doaj.org/article/60e2a85296fe4c9a9862e99e0ddca3a6
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-8 (2021)
Abstract Mitochondrial apoptosis regulates survival and development of hematopoietic cells. Prominent roles of some Bcl-2-family members in this regulation have been established, for instance for pro-apoptotic Bim and anti-apoptotic Mcl-1. Additional
Externí odkaz:
https://doaj.org/article/1686e2a09ca14636b1c80fb0e013429f
Autor:
Beate J. Müller, Arne Westheider, Katharina Birkner, Birte Seelig, Susanne Kirschnek, Christian Bogdan, Friederike D. von Loewenich
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Anaplasma phagocytophilum is a tick-transmitted obligate intracellular Gram-negative bacterium that replicates in neutrophils. It elicits febrile disease in humans and in animals. In a mouse model, elimination of A. phagocytophilum required CD4+ T ce
Externí odkaz:
https://doaj.org/article/4829ce359de2427788d97c61eaad5232
Publikováno v:
Parasites & Vectors, Vol 10, Iss 1, Pp 1-12 (2017)
Abstract Background Anaplasma phagocytophilum is a Gram-negative obligate intracellular bacterium that is transmitted by ticks of the Ixodes ricinus complex. It replicates in neutrophils and elicits febrile disease in humans and animals. Because of i
Externí odkaz:
https://doaj.org/article/eb5e1cf03c3f439fac2e51838f6ee838
Autor:
Maja Sochalska, Magdalena B. Stańczyk, Maria Użarowska, Natalia Zubrzycka, Susanne Kirschnek, Aleksander M. Grabiec, Tomasz Kantyka, Jan Potempa
Publikováno v:
Pathogens, Vol 9, Iss 7, p 530 (2020)
(1) Background: Studying neutrophils in vitro is difficult since these cells are terminally differentiated and are easily activated during isolation. At the same time, most of the available model cell lines are associated with certain limitations, su
Externí odkaz:
https://doaj.org/article/736c627c92424dffb85d47e0fc0a60ec
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168055 (2016)
Severe congenital neutropenia (SCN) is characterised by a differentiation block in the bone marrow and low neutrophil numbers in the peripheral blood, which correlates with increased risk of bacterial infections. Several underlying gene defects have
Externí odkaz:
https://doaj.org/article/4e082e5e17d449a39da0fb049bd184f2
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/ef68abd3dd4f4df792444dadfe595ad9
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79352 (2013)
Neutrophil granulocyte (neutrophil) apoptosis plays a key role in determining inflammation in infectious and non-infectious settings. Recent work has shown that inhibitors of cyclin-dependent kinases (cdk) such as roscovitine can potently induce neut
Externí odkaz:
https://doaj.org/article/4da23675a46847c3b4e5e0d32eb6d732
Autor:
Pedro Eitz Ferrer, Stephanie Potthoff, Susanne Kirschnek, Georg Gasteiger, Wolfgang Kastenmüller, Holger Ludwig, Stefan A Paschen, Andreas Villunger, Gerd Sutter, Ingo Drexler, Georg Häcker
Publikováno v:
PLoS Pathogens, Vol 7, Iss 6, p e1002083 (2011)
Viral infection is a stimulus for apoptosis, and in order to sustain viral replication many viruses are known to carry genes encoding apoptosis inhibitors. F1L, encoded by the orthopoxvirus modified vaccinia virus Ankara (MVA) has a Bcl-2-like struct
Externí odkaz:
https://doaj.org/article/b2a18fb60b3b46f3bf1d8cf5cc6b39f8