Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Susanne Kämmerer"'
Autor:
Stephan R. Künzel, Erik Klapproth, Nick Zimmermann, Susanne Kämmerer, Mario Schubert, Karolina Künzel, Maximilian Hoffmann, Stephan Drukewitz, Anne Vehlow, Jiri Eitler, Marieke Arriens, Jessica Thiel, Romy Kronstein-Wiedemann, Maximiliane Tietze, Stefan Beissert, Bertold Renner, Ali El-Armouche, Claudia Günther
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Radiation-induced morphea (RIM) is a rare complication of radiotherapy presenting as inflammatory fibrosis, most commonly reported in breast cancer patients. As underlying disease mechanisms are not well understood, targeted therapies are la
Externí odkaz:
https://doaj.org/article/ca14d9c2e1744a85acf698b849bb68f5
Autor:
Stephan R. Künzel, Luise Winter, Maximilian Hoffmann, Theresa A. Kant, Jessica Thiel, Romy Kronstein‐Wiedemann, Erik Klapproth, Kristina Lorenz, Ali El‐Armouche, Susanne Kämmerer
Publikováno v:
Physiological Reports, Vol 11, Iss 17, Pp n/a-n/a (2023)
Abstract Objectives Myocardial infarction (MI) initiates a complex reparative response during which damaged cardiac muscle is replaced by connective tissue. While the initial repair is essential for survival, excessive fibrosis post‐MI is a primary
Externí odkaz:
https://doaj.org/article/d4acd0cfd97d4bfd97efddc275319cda
Autor:
Erik Klapproth, Anke Witt, Pauline Klose, Johanna Wiedemann, Nikitha Vavilthota, Stephan R. Künzel, Susanne Kämmerer, Mario Günscht, David Sprott, Mathias Lesche, Fabian Rost, Andreas Dahl, Erik Rauch, Lars Kattner, Silvio Weber, Peter Mirtschink, Irakli Kopaliani, Kaomei Guan, Kristina Lorenz, Paul Saftig, Michael Wagner, Ali El-Armouche
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Therapeutic interference with the immune response after myocardial infarction holds the potential to close a clinically relevant gap. Here, the authors show that inhibition of a cardiomyocyte-specific ADAM10 / CX3CL1 axis improves post infarction sur
Externí odkaz:
https://doaj.org/article/8d786fd470964db7bb4c1cae17ec3150
Autor:
Theresa A. Kant, Manja Newe, Luise Winter, Maximilian Hoffmann, Susanne Kämmerer, Erik Klapproth, Karolina Künzel, Mark P. Kühnel, Lavinia Neubert, Ali El-Armouche, Stephan R. Künzel
Publikováno v:
Cells, Vol 10, Iss 3, p 617 (2021)
Pulmonary fibrosis is the chronic-progressive replacement of healthy lung tissue by extracellular matrix, leading to the destruction of the alveolar architecture and ultimately death. Due to limited pathophysiological knowledge, causal therapies are
Externí odkaz:
https://doaj.org/article/ce7d379484ec469ba064c6024e626d19
Autor:
Eleder Cachorro, Mario Günscht, Mario Schubert, Mirna S. Sadek, Johanna Siegert, Fabian Dutt, Carla Bauermeister, Susann Quickert, Henrik Berning, Felix Nowakowski, Simon Lämmle, Rebecca Firneburg, Xiaojing Luo, Stephan R. Künzel, Erik Klapproth, Peter Mirtschink, Manuel Mayr, Matthias Dewenter, Christiane Vettel, Jordi Heijman, Kristina Lorenz, Kaomei Guan, Ali El-Armouche, Michael Wagner, Susanne Kämmerer
Publikováno v:
Circulation Research, 132(4), 400-414. LIPPINCOTT WILLIAMS & WILKINS
Background: Ventricular arrhythmia and sudden cardiac death are the most common lethal complications after myocardial infarction. Antiarrhythmic pharmacotherapy remains a clinical challenge and novel concepts are highly desired. Here, we focus on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb50bec3e2e3a5fa28e319482d0a9bc
https://doi.org/10.1161/circresaha.122.322031
https://doi.org/10.1161/circresaha.122.322031
Autor:
Eleder Cachorro Puente, Mario Günscht, Mario Schubert, Mirna Fahmi, Johanna Siegert, Henrick Berning, Kaomei Guan, Ali El-Armouche, Michael Wagner, Susanne Kämmerer
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:142-143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40d9013146fddb8ef265f456cbf6e318
https://doi.org/10.1016/j.yjmcc.2022.08.281
https://doi.org/10.1016/j.yjmcc.2022.08.281
Autor:
Erich Wettwer, Katharina Metzner, Torsten Christ, Michael Schaefer, Ali El-Armouche, Dobromir Dobrev, Susanne Kämmerer, Stephan R Künzel, Fabian Belau, Ursula Ravens, Wener Li
Publikováno v:
International Journal of Cardiology. 284:68-73
Background Cardiac accessory β-subunits are part of macromolecular Nav1.5 channel complexes modulating biophysical properties and contributing to arrhythmias. Recent studies demonstrated the structural interaction between β-subunits of Na+ (Nav1.5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2eda91c19f02bf3c87abeb94fc0474
https://doi.org/10.1016/j.ijcard.2018.12.072
https://doi.org/10.1016/j.ijcard.2018.12.072
Autor:
Silvio Weber, Maximilian Hoffmann, Susanne Kämmerer, Molly O’Reilly, Ali El-Armouche, Mirna S. Sadek, Sems Malte Tugtekin, Ben Wielockx, Pauline Wimberger, Mario Günscht, L C Sommerfeld, Natalie Herzog, Ursula Ravens, Larissa Fabritz, Stefan Rose-John, Jan-Heiner Küpper, Kaomei Guan, Erik Klapproth, S. Nashitha Kabir, Tomasz Kolanowski, Jan Dominik Kuhlmann, Michael Wagner, Manuel Mayr, Stefanie Meyer-Roxlau, Stephan R Künzel, Konrad Grützmann, Stanley Nattel, Karolina Künzel, Xiaoke Yin, C. Piorkowski, Johanna S E Rausch, Dobromir Dobrev
Publikováno v:
Circulation Research
Supplemental Digital Content is available in the text.
Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will o
Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e048dfbc460665ba37f1c2b2bbe8d1
https://www.ncbi.nlm.nih.gov/pubmed/34433292
https://www.ncbi.nlm.nih.gov/pubmed/34433292
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7462, p 7462 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Phosphodiesterases (PDEs) are the principal superfamily of enzymes responsible for degrading the secondary messengers 3’,5’-cyclic nucleotides cAMP and cGMP. Their refined subcellular localization and substrate specificity contribute to finely re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f0022948c3a6ccac2a00bd9787bf45
https://www.mdpi.com/1422-0067/21/20/7462
https://www.mdpi.com/1422-0067/21/20/7462
Autor:
Silvio Weber, Ali R. Saadatmand, Daniel Finke, Lorenz H. Lehmann, Marco Hagenmueller, Carsten Sticht, Susanne Kämmerer, Johannes Backs, Till Wüstemann, Matthias Dewenter, Ali El-Armouche, Martin Kramer, Samuel Sossalla, Stephan R. Kuenzel, Viviana Sramek, Stefanie Meyer-Roxlau, Norbert Gretz
Sympathetic activation of β-adrenoreceptors (β-AR) represents a hallmark in the development of heart failure (HF). However, little is known about the underlying mechanisms of gene regulation. In human ventricular myocardium from patients with end-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86e80c3aee7ed364648f5ada6f928fc
https://europepmc.org/articles/PMC6825262/
https://europepmc.org/articles/PMC6825262/