Genotoxicity assessment of chemical mixtures

Autor: EFSA Scientific Committee, Simon More, Vasileios Bampidis, Diane Benford, Jos Boesten, Claude Bragard, Thorhallur Halldorsson, Antonio Hernandez‐Jerez, Susanne Hougaard‐Bennekou, Kostas Koutsoumanis, Hanspeter Naegeli, Søren Saxmose Nielsen, Dieter Schrenk, Vittorio Silano, Dominique Turck, Maged Younes, Gabriele Aquilina, Riccardo Crebelli, Rainer Gürtler, Karen Ildico Hirsch‐Ernst, Pasquale Mosesso, Elsa Nielsen, Roland Solecki, Maria Carfì, Carla Martino, Daniela Maurici, Juan Parra Morte, Josef Schlatter

Publikováno v: EFSA Journal, Vol 17, Iss 1, Pp n/a-n/a (2019)

Abstract The EFSA Scientific Committee addressed in this document the peculiarities related to the genotoxicity assessment of chemical mixtures. The EFSA Scientific Committee suggests that first a mixture should be chemically characterised as far as

Externí odkaz: https://doaj.org/article/9fb20cf2ce074404896b499ed2599a71

Guidance on risk–benefit assessment of foods

Autor: EFSA Scientific Committee, Simon John More, Diane Benford, Susanne Hougaard Bennekou, Vasileios Bampidis, Claude Bragard, Thorhallur Ingi Halldorsson, Antonio F. Hernández‐Jerez, Kostas Koutsoumanis, Claude Lambré, Kyriaki Machera, Ewen Mullins, Søren Saxmose Nielsen, Josef Schlatter, Dieter Schrenk, Dominique Turck, Androniki Naska, Morten Poulsen, Jukka Ranta, Salomon Sand, Heather Wallace, Maria Bastaki, Djien Liem, Anthony Smith, Ermolaos Ververis, Giorgia Zamariola, Maged Younes

Publikováno v: EFSA Journal, Vol 22, Iss 7, Pp n/a-n/a (2024)

Abstract The EFSA Scientific Committee has updated its 2010 Guidance on risk–benefit assessment (RBA) of foods. The update addresses methodological developments and regulatory needs. While it retains the stepwise RBA approach, it provides additiona

Externí odkaz: https://doaj.org/article/917140789e36469ba9a65bd11763b703

Re‐evaluation of the existing health‐based guidance values for copper and exposure assessment from all sources

Autor: EFSA Scientific Committee, Simon John More, Vasileios Bampidis, Diane Benford, Claude Bragard, Thorhallur Ingi Halldorsson, Antonio F Hernández‐Jerez, Susanne Hougaard Bennekou, Kostas Koutsoumanis, Claude Lambré, Kyriaki Machera, Ewen Mullins, Søren Saxmose Nielsen, Josef R Schlatter, Dieter Schrenk, Dominique Turck, Maged Younes, Polly Boon, Gordon AA Ferns, Oliver Lindtner, Erik Smolders, Martin Wilks, Maria Bastaki, Agnès deSesmaisons‐Lecarré, Lucien Ferreira, Luna Greco, George E N Kass, Francesca Riolo, Jean‐Charles Leblanc

Publikováno v: EFSA Journal, Vol 21, Iss 1, Pp n/a-n/a (2023)

Abstract Copper is an essential micronutrient and also a regulated product used in organic and in conventional farming pest management. Both deficiency and excessive exposure to copper can have adverse health effects. In this Scientific Opinion, the

Externí odkaz: https://doaj.org/article/e4b4ef00114d44d293edda9ff5e8fe09

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

Autor: Elina Drakvik, Rolf Altenburger, Yasunobu Aoki, Thomas Backhaus, Tina Bahadori, Robert Barouki, Werner Brack, Mark T.D. Cronin, Barbara Demeneix, Susanne Hougaard Bennekou, Jacob van Klaveren, Carsten Kneuer, Marike Kolossa-Gehring, Erik Lebret, Leo Posthuma, Lena Reiber, Cynthia Rider, Joëlle Rüegg, Giuseppe Testa, Bart van der Burg, Hilko van der Voet, A. Michael Warhurst, Bob van de Water, Kunihiko Yamazaki, Mattias Öberg, Åke Bergman

Publikováno v: Environment International, Vol 134, Iss , Pp - (2020)

The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical a

Externí odkaz: https://doaj.org/article/c43c2dfa7ba44c1fbb764a91e6a1d76e

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

Autor: Wanda van der Stel, Susanne Hougaard Bennekou, Anna Forsby, Paul Jennings, Johannes Delp, Marcel Leist, Bob van de Water, Ilinca Suciu, Petra Kranaster, Giada Carta, Vesna Munic Kos, Andrea Cediel-Ulloa, Barbara M.A. van Vugt-Lussenburg

Publikováno v: Archives of Toxicology
Delp, J, Cediel-Ulloa, A, Suciu, I, Kranaster, P, van Vugt-Lussenburg, B M, Munic Kos, V, van der Stel, W, Carta, G, Bennekou, S H, Jennings, P, van de Water, B, Forsby, A & Leist, M 2021, ' Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors ', Archives of Toxicology, vol. 95, no. 2, pp. 591-615 . https://doi.org/10.1007/s00204-020-02970-5
Archives of Toxicology, 95, 591-615. Springer Science and Business Media LLC
Archives of Toxicology, 95(2), 591-615. Springer Verlag
Delp, J, Cediel-Ulloa, A, Suciu, I, Kranaster, P, van Vugt-Lussenburg, B M, Munic Kos, V, van der Stel, W, Carta, G, Bennekou, S H, Jennings, P, van de Water, B, Forsby, A & Leist, M 2021, ' Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors ', Archives of Toxicology, vol. 95, pp. 591–615 . https://doi.org/10.1007/s00204-020-02970-5

Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-phenylpyridinium (MPP +) leads to the degeneration of dopaminergic neurons in man and rodents. To formally describe this mechanism of toxicity, an adverse outc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61f9e7082c9e7401241b565844c2030
https://doi.org/10.1007/s00204-020-02970-5