Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Susanne Homolka"'
Autor:
Rachel F. Rollo, Giorgia Mori, Timothy A. Hill, Doris Hillemann, Stefan Niemann, Susanne Homolka, David P. Fairlie, Antje Blumenthal
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Shorter and more effective treatment regimens as well as new drugs are urgent priorities for reducing the immense global burden of tuberculosis (TB). As treatment of TB currently requires multiple antibiotics with diverse mechanisms of actio
Externí odkaz:
https://doaj.org/article/833f0bedf8da40d99d8b123434117953
Autor:
Francy J. Pérez-Llanos, Viola Dreyer, Ivan Barilar, Christian Utpatel, Thomas A. Kohl, Martha Isabel Murcia, Susanne Homolka, Matthias Merker, Stefan Niemann
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Whole genome sequencing (WGS) has become the main tool for studying the transmission of Mycobacterium tuberculosis complex (MTBC) strains; however, the clonal expansion of one strain often limits its application in local MTBC outbreaks. The
Externí odkaz:
https://doaj.org/article/c0f5b91364cd4a4f93b2be419610ed5d
Autor:
Barbara Tizzano, Tobias K. Dallenga, Christian Utpatel, Jochen Behrends, Susanne Homolka, Thomas A. Kohl, Stefan Niemann
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract While persistence in a dormant state is crucial for the life cycle of Mycobacterium tuberculosis, no investigation regarding dormancy survival of different strains across different lineages was performed so far. We analyzed responses to oxyg
Externí odkaz:
https://doaj.org/article/7f2f6c503bcb445e86133e23a4540b04
Autor:
Susanne Homolka, Laura Paulowski, Sönke Andres, Doris Hillemann, Ruwen Jou, Gunar Günther, Mareli Claassens, Martin Kuhns, Stefan Niemann, Florian P. Maurer
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 11, Pp 2549-2554 (2020)
In many settings, the ongoing coronavirus disease (COVID-19) pandemic coincides with other major public health threats, in particular tuberculosis. Using tuberculosis (TB) molecular diagnostic infrastructure, which has substantially expanded worldwid
Externí odkaz:
https://doaj.org/article/762934f1ee3040c7bee534d21787d5c0
Autor:
Nicolas Gisch, Christian Utpatel, Lisa M. Gronbach, Thomas A. Kohl, Ursula Schombel, Sven Malm, Karen M. Dobos, Danny C. Hesser, Roland Diel, Udo Götsch, Silke Gerdes, Yassir A. Shuaib, Nyanda E. Ntinginya, Celso Khosa, Sofia Viegas, Glennah Kerubo, Solomon Ali, Sahal A. Al-Hajoj, Perpetual W. Ndung’u, Andrea Rachow, Michael Hoelscher, Florian P. Maurer, Dominik Schwudke, Stefan Niemann, Norbert Reiling, Susanne Homolka
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
“Ancestral” Mycobacterium tuberculosis complex (MTBC) strains of Lineage 1 (L1, East African Indian) are a prominent tuberculosis (TB) cause in countries around the Indian Ocean. However, the pathobiology of L1 strains is insufficiently character
Externí odkaz:
https://doaj.org/article/d89af2c5cf0e449ba33491933f596aaf
Autor:
Glennah Kerubo, Perpetua Ndungu, Yassir Adam Shuaib, Evans Amukoye, Gunturu Revathi, Susanne Homolka, Samuel Kariuki, Matthias Merker, Stefan Niemann
Publikováno v:
Genes, Vol 13, Iss 3, p 475 (2022)
Kenya is a country with a high tuberculosis (TB) burden. However, knowledge on the genetic diversity of Mycobacterium tuberculosis complex (MTBC) strains and their transmission dynamics is sparsely available. Hence, we used whole-genome sequencing (W
Externí odkaz:
https://doaj.org/article/5b477249100140248c6e80448158bf04
Autor:
Hillary N Wood, Tom Venken, Hanny Willems, An Jacobs, Ana Júlia Reis, Pedro Eduardo Almeida da Silva, Susanne Homolka, Stefan Niemann, Kyle H Rohde, Jef Hooyberghs
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212064 (2019)
In Mycobacterium tuberculosis (Mtb) the detection of single nucleotide polymorphisms (SNPs) is of high importance both for diagnostics, since drug resistance is primarily caused by the acquisition of SNPs in multiple drug targets, and for epidemiolog
Externí odkaz:
https://doaj.org/article/45a954b792a34298a53687ff5fff3395
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0222925 (2019)
BACKGROUND:High quality diagnostic services are crucial for tuberculosis (TB) diagnosis, treatment and control. A strong laboratory quality management system (QMS) is critical to ensuring the quality of testing and results. Recent initiatives to impr
Externí odkaz:
https://doaj.org/article/2f7f69149fc74a8cb824b7030ca7b91d
Autor:
Yassir A. Shuaib, Eltahir A. G. Khalil, Ulrich E. Schaible, Lothar H. Wieler, Mohammed A. M. Bakheit, Saad E. Mohamed-Noor, Mohamed A. Abdalla, Susanne Homolka, Sönke Andres, Doris Hillemann, Knut Lonnroth, Elvira Richter, Stefan Niemann, Katharina Kranzer
Publikováno v:
Tuberculosis Research and Treatment, Vol 2018 (2018)
Background. In Sudan, tuberculosis diagnosis largely relies on clinical symptoms and smear microscopy as in many other low- and middle-income countries. The aim of this study was to investigate the positive predictive value of a positive sputum smear
Externí odkaz:
https://doaj.org/article/7540cba04fa24e14a92e108d14e5cc84
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152200 (2016)
The development of an effective vaccine is urgently needed to fight tuberculosis (TB) which is still the leading cause of death from a single infectious agent worldwide. One of the promising vaccine candidates M72/AS01E consists of two proteins subun
Externí odkaz:
https://doaj.org/article/e09b22ea84254f41bfca9277932be37e