Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Susanne Herbst"'
Autor:
Olga Sarenko, Gisela Klauck, Franziska M. Wilke, Vanessa Pfiffer, Anja M. Richter, Susanne Herbst, Volkhard Kaever, Regine Hengge
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT The bacterial second messenger bis-(3′-5′)-cyclic diguanosine monophosphate (c-di-GMP) ubiquitously promotes bacterial biofilm formation. Intracellular pools of c-di-GMP seem to be dynamically negotiated by diguanylate cyclases (DGCs, wi
Externí odkaz:
https://doaj.org/article/89a908d5c80b40169b9bc7709af9f298
Autor:
Susanne Herbst, Anand Shah, Maria Mazon Moya, Vanessa Marzola, Barbara Jensen, Anna Reed, Mark A Birrell, Shinobu Saijo, Serge Mostowy, Sunil Shaunak, Darius Armstrong‐James
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 3, Pp 240-258 (2015)
Abstract Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineur
Externí odkaz:
https://doaj.org/article/13031244d16d4b3ba809b9ade5152b6d
Autor:
Susanne Herbst, Anand Shah, Martin Carby, Gary Chusney, Naresh Kikkeri, Anthony Dorling, Elaine Bignell, Sunil Shaunak, Darius Armstrong-James
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 3, Pp 643-651 (2013)
SUMMARY Invasive fungal infections (IFIs) are a major cause of death in organ transplant patients. The murine hydrocortisone-mediated immunosuppression model of pulmonary aspergillosis is commonly used to characterise IFIs in these patients. However,
Externí odkaz:
https://doaj.org/article/52fedae40da243889556fdffa43cdeb1
Autor:
Margherita Bertuzzi, Markus Schrettl, Laura Alcazar-Fuoli, Timothy C Cairns, Alberto Muñoz, Louise A Walker, Susanne Herbst, Maryam Safari, Angela M Cheverton, Dan Chen, Hong Liu, Shinobu Saijo, Natalie D Fedorova, Darius Armstrong-James, Carol A Munro, Nick D Read, Scott G Filler, Eduardo A Espeso, William C Nierman, Hubertus Haas, Elaine M Bignell
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1004943 (2015)
Externí odkaz:
https://doaj.org/article/c880268257a74b16a9be6c171f0b5a5e
Autor:
Margherita Bertuzzi, Markus Schrettl, Laura Alcazar-Fuoli, Timothy C Cairns, Alberto Muñoz, Louise A Walker, Susanne Herbst, Maryam Safari, Angela M Cheverton, Dan Chen, Hong Liu, Shinobu Saijo, Natalie D Fedorova, Darius Armstrong-James, Carol A Munro, Nick D Read, Scott G Filler, Eduardo A Espeso, William C Nierman, Hubertus Haas, Elaine M Bignell
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004413 (2014)
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal proteases, A. fumigatus mutants lacking indivi
Externí odkaz:
https://doaj.org/article/eb8eb45ee83a4e99a63533f7c78440cd
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19105 (2011)
Mycobacterium tuberculosis is an intracellular pathogen of macrophages and escapes the macrophages' bactericidal effectors by interfering with phagosome-lysosome fusion. IFN-γ activation renders the macrophages capable of killing intracellular mycob
Externí odkaz:
https://doaj.org/article/ddcb38bbbc7d44468df8cf57360d610d
Autor:
Susanne Herbst, Patrick A. Lewis
Publikováno v:
Biochemical Journal
Since the discovery of mutations in leucine-rich repeat kinase 2 (LRRK2) as an underlying genetic cause for the development of Parkinson's disease (PD) in 2004 (Neuron 44, 601–607; Neuron 44, 595–600), and subsequent efforts to develop LRRK2 kina
Autor:
Susanne Herbst
Protocol for immunofluorescent staining for LRRK2 in cultured cells using the MJFF2 (c41-2) antibody.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12ce325485914405be333a8fe0dd1607
https://doi.org/10.17504/protocols.io.n92ldze17v5b/v1
https://doi.org/10.17504/protocols.io.n92ldze17v5b/v1
Autor:
Nadezhda Malysheva, Anja M. Richter, Regine Hengge, Alexandra Possling, Kaveh Pouran Yousef, Susanne Herbst, Max von Kleist
Publikováno v:
Journal of Molecular Biology
In many bacteria, the biofilm-promoting second messenger c-di-GMP is produced and degraded by multiple diguanylate cyclases (DGC) and phosphodiesterases (PDE), respectively. High target specificity of some of these enzymes has led to theoretical conc
Publikováno v:
Clinical science (London, England : 1979). 136(13)
Parkinson’s disease (PD) is conventionally described as an α-synuclein aggregation disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common autosomal dominant cause of PD. However, LR