Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Susanne Heck"'
Autor:
Valeria Manuelli, Fidelma Cahill, Harriet Wylie, Cheryl Gillett, Isabel Correa, Susanne Heck, Alex Rimmer, Anna Haire, Mieke Van Hemelrijck, Sarah Rudman, Claire M. Wells
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Invadopodia, actin-rich structures that release metallo-proteases at the interface with extra-cellular matrix, in a punctate manner are thought to be important drivers of tumour invasion. Invadopodia formation has been observed in
Externí odkaz:
https://doaj.org/article/8fa0d54a37554369a610152247a40796
Autor:
Yuan Zhao, Mohamed Uduman, Jacqueline H. Y. Siu, Thomas J. Tull, Jeremy D. Sanderson, Yu-Chang Bryan Wu, Julian Q. Zhou, Nedyalko Petrov, Richard Ellis, Katrina Todd, Konstantia-Maria Chavele, William Guesdon, Anna Vossenkamper, Wayel Jassem, David P. D’Cruz, David J. Fear, Susan John, Dagmar Scheel-Toellner, Claire Hopkins, Estefania Moreno, Natalie L. Woodman, Francesca Ciccarelli, Susanne Heck, Steven H. Kleinstein, Mats Bemark, Jo Spencer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Human memory and marginal zone B cells share some features including CD27 expression and somatic hypermutation, but their lineage relationship is still unclear. Here the authors use mass cytometry and sequential clustering methods to show that, despi
Externí odkaz:
https://doaj.org/article/18e17622ab574decbfaad7cce6011bef
Autor:
Federica Villanova, Paola Di Meglio, Margaret Inokuma, Nima Aghaeepour, Esperanza Perucha, Jennifer Mollon, Laurel Nomura, Maria Hernandez-Fuentes, Andrew Cope, A Toby Prevost, Susanne Heck, Vernon Maino, Graham Lord, Ryan R Brinkman, Frank O Nestle
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e65485 (2013)
Discovery of novel immune biomarkers for monitoring of disease prognosis and response to therapy in immune-mediated inflammatory diseases is an important unmet clinical need. Here, we establish a novel framework for immunological biomarker discovery,
Externí odkaz:
https://doaj.org/article/29156ce7ba8347c983bb5973c1a6494f
Autor:
Patrycja M Dubielecka, Ping Cui, Xiaoling Xiong, Sajjad Hossain, Susanne Heck, Lyudmil Angelov, Leszek Kotula
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10430 (2010)
Macropinocytosis, which is a constitutive cellular process of fluid and macromolecule uptake, is regulated by actin cytoskeleton rearrangements near the plasma membrane. Activation of Rac1, which is proposed to act upstream of the actin polymerizatio
Externí odkaz:
https://doaj.org/article/a78218453eb64bcd8346bbae95c74712
Autor:
Sabrina Kirschke, Jannis Glahe, Christine Ahrend, Miriam Brandt, Susanne Hecker, Julia Krohmer, Sebastian Lentz, Niklas Marzinek, Stefanie Molthagen-Schnöring, Mhairi Stewart, Silke Voigt-Heucke
Publikováno v:
Research Ideas and Outcomes, Vol 10, Iss , Pp 1-20 (2024)
Diverse actors within and outside the academic system increasingly call upon scientists to engage with the public through science communication as part of their academic work. This raises the question of how these actors' demands can and should be me
Externí odkaz:
https://doaj.org/article/13522ea7cc1e4e3a90414223e8a0a2de
Autor:
Dirk Ritzmann, Magdalena Jahn, Susanne Heck, Cristina Jung, Tiziana Cesetti, Nathalie Couturier, Rüdiger Rudolf, Naemi Reuscher, Claudia Buerger, Oliver Rauh, Torsten Fauth
Publikováno v:
Cell Calcium. 111:102715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52c2ad04fcf655a0114f76e02a8ecb28
https://doi.org/10.1016/j.ceca.2023.102715
https://doi.org/10.1016/j.ceca.2023.102715
Autor:
Juan José Lozano, Linda Ariza-McNaughton, Jonathan M. Irish, Syed A Mian, Benedetta Costantini, Judith C. W. Marsh, Dominique Bonnet, Shahram Kordasti, Thanos P. Mourikis, Shok Ping Lim, Pilar Perez Abellan, Giovanni A M Povoleri, Ghulam J. Mufti, Susanne Heck, Giovanna Lombardi, Ander Abarrategi, Shreyans Gandhi, Marc Martinez Llordella, Rita Antunes Dos Reis
Publikováno v:
Blood. 136:885-897
Idiopathic aplastic anemia (AA) has 2 key characteristics: an autoimmune response against hematopoietic stem/progenitor cells and regulatory T-cells (Tregs) deficiency. We have previously demonstrated reduction in a specific subpopulation of Treg in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55ae0d92bc89d6a0015a27e7bff1ccb
https://doi.org/10.1182/blood.2019001347
https://doi.org/10.1182/blood.2019001347
Autor:
Benedetta Costantini, Lynne M. Mitchell, Claudia Kemper, Voon H Ong, Giuseppina Arbore, Kevin Blighe, Christopher P. Denton, Shahram Kordasti, Trent M. Woodruff, Dennis E. Hourcade, Leo Placais, Richard Ellis, Paola Nocerino, Susanne Heck, David Abraham
Publikováno v:
Cellular and Molecular Immunology
Arbore, G, Ong, V H, Costantini, B, Denton, C P, Abraham, D, Placais, L, Blighe, K, Mitchell, L, Ellis, R, Heck, S, Nocerino, P, Woodruff, T M, Kordasti, S, Kemper, C & Hourcade, D E 2020, ' Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis ', Cellular and Molecular Immunology, vol. 17, no. 9, pp. 1010-1013 . https://doi.org/10.1038/s41423-019-0360-8
Arbore, G, Ong, V H, Costantini, B, Denton, C P, Abraham, D, Placais, L, Blighe, K, Mitchell, L, Ellis, R, Heck, S, Nocerino, P, Woodruff, T M, Kordasti, S, Kemper, C & Hourcade, D E 2020, ' Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis ', Cellular and Molecular Immunology, vol. 17, no. 9, pp. 1010-1013 . https://doi.org/10.1038/s41423-019-0360-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4af1cea1e941fbd4949f34f922ce3b9
https://doi.org/10.1038/s41423-019-0360-8
https://doi.org/10.1038/s41423-019-0360-8
Autor:
Valeria Manuelli, Fidelma Cahill, Harriet Wylie, Cheryl Gillett, Isabel Correa, Susanne Heck, Alex Rimmer, Anna Haire, Mieke Van Hemelrijck, Sarah Rudman, Claire M. Wells
Publikováno v:
Manuelli, V, Cahill, F, Wylie, H, Gillett, C, Correa, I, Heck, S, Rimmer, A, Haire, A, Van Hemelrijck, M, Rudman, S & Wells, C 2022, ' Invadopodia play a role in prostate cancer progression ', BMC Cancer, vol. 22, no. 1, 386 . https://doi.org/10.1186/s12885-022-09424-4
Background Invadopodia, actin-rich structures that release metallo-proteases at the interface with extra-cellular matrix, in a punctate manner are thought to be important drivers of tumour invasion. Invadopodia formation has been observed in-vitro an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72574a5797a2b905249c85bfd6ddbb84
https://pubmed.ncbi.nlm.nih.gov/35397545
https://pubmed.ncbi.nlm.nih.gov/35397545
Autor:
William Guesdon, Michael J. Pitcher, Yuan Zhao, Cristina Lebrero-Fernández, Richard Groves, Wayel Jassem, Michelle Kleeman, Susanne Heck, Yogesh Kamra, David J. Fear, David D'Cruz, Richard Ellis, Susan D. John, Ulrich D. Kadolsky, Nedyalko Petrov, Pawan Dhami, Jeremy D. Sanderson, Thomas J Tull, Mats Bemark, Jacqueline Hy Siu, Jo Spencer, Michael D. Robson
Publikováno v:
Spencer, J, Tull, T, Pitcher, M, Guesdon, W, Siu, J HY, Lebraro-Fernandez, C, Zhao, Y, Petrov, N, Heck, S, Ellis, R, Dhami, P, kadolsky, U, Kleeman, M, Kamra, Y, Fear, D, John, S, Jassem, W, Groves, R, Sanderson, J D, Robson, M, D’Cruz, D & Bemark, M 2021, ' Human marginal zone B cell development from early T2 progenitors ', Journal of Experimental Medicine, vol. 218, no. 4, e20202001 . https://doi.org/10.1084/jem.20202001
The Journal of Experimental Medicine
The Journal of Experimental Medicine
This study identifies a developmental trajectory from human IgMhi gut homing transitional 2 cells to marginal zone B cells, all stages of which are affected in patients with severe systemic lupus erythematosus.
B cells emerge from the bone marro
B cells emerge from the bone marro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb8c2c762c335e87f1bb70f46e6047e
https://doi.org/10.1101/2020.09.24.311498
https://doi.org/10.1101/2020.09.24.311498
