Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Susanne H Schenk"'
Autor:
Dominik Witzigmann, Philipp Uhl, Sandro Sieber, Christina Kaufman, Tomaz Einfalt, Katrin Schöneweis, Philip Grossen, Jonas Buck, Yi Ni, Susanne H Schenk, Janine Hussner, Henriette E Meyer zu Schwabedissen, Gabriela Québatte, Walter Mier, Stephan Urban, Jörg Huwyler
Publikováno v:
eLife, Vol 8 (2019)
Active targeting and specific drug delivery to parenchymal liver cells is a promising strategy to treat various liver disorders. Here, we modified synthetic lipid-based nanoparticles with targeting peptides derived from the hepatitis B virus large en
Externí odkaz:
https://doaj.org/article/06772f8c9ffb44f5b5c021716f8aad26
Autor:
Claudio L. Alter, Pascal Detampel, Roman B. Schefer, Claudia Lotter, Patrick Hauswirth, Ramya D. Puligilla, Vera J. Weibel, Susanne H. Schenk, Wolf Heusermann, Melanie Schürz, Nicole Meisner-Kober, Cornelia Palivan, Tomaž Einfalt, Jörg Huwyler
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Extracellular vesicles (EVs) are highly interesting for the design of next-generation therapeutics. However, their preparation methods face challenges in standardization, yield, and reproducibility. Here, we describe a highly efficient and r
Externí odkaz:
https://doaj.org/article/be10fbb715fc4794919ad22eb4023b74
Autor:
Bernhard Englinger, Salvatore Piscuoglio, Jean Rommelaere, Dominik Witzigmann, Sushilla van Schoonhoven, Walter Berger, David Grünig, Xue-Ting Tran, Patrick Hauswirth, Susanne H. Schenk, Stephan Krähenbühl, Jörg Huwyler, Luigi Terracciano, Manuela Lanzafame, Philip Grossen, Cristina Quintavalle, Jürg P. F. Nüesch, Luca Quagliata
Publikováno v:
Journal of Controlled Release. 334:138-152
Hepatocellular carcinoma (HCC) is related to increasing incidence rates and poor clinical outcomes due to lack of efficient treatment options and emerging resistance mechanisms. The aim of the present study is to exploit a non-viral gene therapy enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bad076640ca4aef3965956cab86bff0
https://doi.org/10.1016/j.jconrel.2021.04.023
https://doi.org/10.1016/j.jconrel.2021.04.023
Autor:
Stephan Urban, Anna Pratsinis, Philipp Uhl, Dominik Witzigmann, Walter Mier, Susanne H. Schenk, Jörg Huwyler, Patrick Hauswirth, Jan Stephan Bolten
Publikováno v:
Molecular Pharmaceutics. 18:2004-2014
Recently, a lipopeptide derived from the hepatitis B virus (HBV) large surface protein has been developed as an HBV entry inhibitor. This lipopeptide, called MyrcludexB (MyrB), selectively binds to the sodium taurocholate cotransporting polypeptide (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691c5183a74f5cec6de1589c7dafd72a
https://doi.org/10.1021/acs.molpharmaceut.0c01222
https://doi.org/10.1021/acs.molpharmaceut.0c01222
Autor:
Jonas, Lötscher, Adrià-Arnau, Martí I Líndez, Nicole, Kirchhammer, Elisabetta, Cribioli, Greta Maria Paola, Giordano Attianese, Marcel P, Trefny, Markus, Lenz, Sacha I, Rothschild, Paolo, Strati, Marco, Künzli, Claudia, Lotter, Susanne H, Schenk, Philippe, Dehio, Jordan, Löliger, Ludivine, Litzler, David, Schreiner, Victoria, Koch, Nicolas, Page, Dahye, Lee, Jasmin, Grählert, Dmitry, Kuzmin, Anne-Valérie, Burgener, Doron, Merkler, Miklos, Pless, Maria L, Balmer, Walter, Reith, Jörg, Huwyler, Melita, Irving, Carolyn G, King, Alfred, Zippelius, Christoph, Hess
Publikováno v:
Cell. 185(4)
The relevance of extracellular magnesium in cellular immunity remains largely unknown. Here, we show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to adopt its active conformation on CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6cfb6d8cca3f0ddb2bc7221e4f0bfe8
https://pubmed.ncbi.nlm.nih.gov/35260350
https://pubmed.ncbi.nlm.nih.gov/35260350
Autor:
Jonas Lötscher, Adrià-Arnau Martí i Líndez, Nicole Kirchhammer, Elisabetta Cribioli, Greta Maria Paola Giordano Attianese, Marcel P. Trefny, Markus Lenz, Sacha I. Rothschild, Paolo Strati, Marco Künzli, Claudia Lotter, Susanne H. Schenk, Philippe Dehio, Jordan Löliger, Ludivine Litzler, David Schreiner, Victoria Koch, Nicolas Page, Dahye Lee, Jasmin Grählert, Dmitry Kuzmin, Anne-Valérie Burgener, Doron Merkler, Miklos Pless, Maria L. Balmer, Walter Reith, Jörg Huwyler, Melita Irving, Carolyn G. King, Alfred Zippelius, Christoph Hess
Publikováno v:
Cell. 185:585-602.e29
The relevance of extracellular magnesium in cellular immunity remains largely unknown. Here, we show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to adopt its active conformation on CD8+ T��cells, thereby augmenting calc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37aac832ab7bc74750040c9812d41abd
https://doi.org/10.1016/j.cell.2021.12.039
https://doi.org/10.1016/j.cell.2021.12.039
Autor:
Alexandra Ernst, Jörg Huwyler, Susanne H. Schenk, Philip Grossen, Fabiola Porta, Dominik Witzigmann, Klara Kiene
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 119:322-332
Nanoparticles, such as polymersomes, can be directed to the hepatic asialoglycoprotein receptor to achieve targeted drug delivery. In this study, we prepared asialofetuin conjugated polymersomes based on the amphiphilic di-block copolymer poly(dimeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f71b496d67b0c08e5732332715ca9a4
https://doi.org/10.1016/j.ejpb.2017.07.002
https://doi.org/10.1016/j.ejpb.2017.07.002
Autor:
Christina Kaufman, Philip Grossen, Sandro Sieber, Stephan Urban, Philipp Uhl, Susanne H. Schenk, Katrin Schöneweis, Yi Ni, Janine Hussner, Jörg Huwyler, Dominik Witzigmann, Henriette E. Meyer zu Schwabedissen, Walter Mier, Gabriela Québatte, Jonas Buck, Tomaz Einfalt
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Active targeting and specific drug delivery to parenchymal liver cells is a promising strategy to treat various liver disorders. Here, we modified synthetic lipid-based nanoparticles with targeting peptides derived from the hepatitis B virus large en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e495040b71a1c524fd1b9f1b551456c
https://doi.org/10.7554/elife.42276
https://doi.org/10.7554/elife.42276
Autor:
Philip Grossen, Katrin Schöneweis, Dominik Witzigmann, Jörg Huwyler, Henriette E. Meyer zu Schwabedissen, Philipp Uhl, Walter Mier, Yi Ni, Tomaz Einfalt, Susanne H. Schenk, Sandro Sieber, Christina Kaufman, Gabriela Québatte, Stephan Urban, Jonas Buck, Janine Hussner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b79dea470ae84697c089f3446bf786b7
https://doi.org/10.7554/elife.42276.042
https://doi.org/10.7554/elife.42276.042
Autor:
Cristina Quintavalle, Luigi Terracciano, Jörg Huwyler, Susanne H. Schenk, Luca Quagliata, Dominik Witzigmann
Publikováno v:
Hepatology Research. 46:686-696
AIM: One of the most promising strategies for the treatment of liver diseases is targeted drug delivery via the asialoglycoprotein receptor (ASGPR). The success of this approach heavily depends on the ASGPR expression level on parenchymal liver cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819f4725b058a5a20ab78278c7f3df24
https://doi.org/10.1111/hepr.12599
https://doi.org/10.1111/hepr.12599