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Autor:
C Leisser, Doris Polgar, Maria Uhl, Michael Grusch, Susanne Gfatter, Georg Krupitza, Fekadu Kassie
Publikováno v:
Current medicinal chemistry. 9(7)
Benzamide riboside (BR) after anabolism to an analogue of NAD, was shown to inhibit the activity of NAD-dependent enzymes such as inosine 5'-monophosphate dehydrogenase (IMPDH), the rate limiting enzyme in de novo guanylate biosynthesis, and malate d