Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Susanne Fang-Kircher"'
Autor:
Gert Lubec, Barbara Lubec, Erwin Kitzmueller, Susanne Fang-Kircher, Harald Hoeger, Wilhelm Mosgoeller, L. Kirchner, Philomena Kastner, Peter Seither
Publikováno v:
Pediatric Research. 53:62-71
RNA polymerases (POL) are integral constituents of the protein synthesis machinery, with POL I and POL III coding for ribosomal RNA and POL II coding for protein. POL I is located in the nucleolus and transcribes class I genes, those that code for la
Autor:
Nigel J. Cairns, Olga Labudova, Gert Lubec, Susanne Fang-Kircher, Erwin Kitzmueller, Hermann Rink
Publikováno v:
Life Sciences. 64:1689-1699
Although deficient DNA-repair was proposed for neurodegenerative disorders including Down Syndrome (DS), repair genes for nucleotide excision repair or X-ray repair have not been studied in brain yet. As one of the hypotheses for the pathogenesis of
Publikováno v:
Neuroscience Letters. 260:9-12
In Down syndrome (DS), enhanced apoptosis (programmed cell death) may play a role in the pathogenesis of characteristic mental retardation and precocious dementia of Alzheimer-type. Upregulation of p53 and APO-1/Fas (CD95) precedes apoptosis in many
Autor:
Susanne Fang-Kircher
Publikováno v:
cclm. 35:47-52
Sialic acids comprise all N- and O-acyl derivatives of neuraminic acid and are components of glycoproteins and glycolipids. Their concentrations vary physiologically with age but also in diseases such as inflammation, neoplastic tumours or in inborn
Autor:
Harald Hoeger, Barbara Lubec, Wilhelm Mosgoeller, Manfred Marx, Susanne Fang-Kircher, Adolf Muehl, J. Gialamas, Olga Labudova
Publikováno v:
Circulation. 94:2620-2625
Background Hyperhomocyst(e)inemia is strongly associated with occlusive arterial disease. A direct effect of homocysteine on the proliferation of smooth muscle cells was proposed recently. This observation led us to examine the effect of homocysteine
Autor:
Harald Hoeger, Philomena Kastner, Olga Labudova, Susanne Fang-Kircher, Wilhelm Mosgoeller, Gert Lubec, Peter Seither, Erwin Kitzmueller, Barbara Lubec
Publikováno v:
Experimental neurology. 161(1)
Ribosomes are integral constitutens of the protein synthesis machinery. Polymerase I (POL I) is located in the nucleolus and transcribes the large ribosomal genes. POL I activity is decreased in ischemia but nothing is known so far on POL I in perina
Autor:
Heike Moenkemann, Susanne Fang-Kircher, N. Cairns, Kristina Yeghiazaryan, Olga Labudova, Gert Lubec
Publikováno v:
Brain research. 806(1)
Performing gene hunting in Down Syndrome fetal brain we detected an overexpressed sequence highly homologous to the human vasopressin gene. As this neuropeptide may be involved in the pathogenetic mechanism and, moreover, was described to play a role
Publikováno v:
Life sciences. 61(8)
Morquio syndrome (mucopolysaccharidosis IV) presents with multiple bone dysplasia and is characterized by the inability to degrade keratan sulfate due to deficient N-acetylgalactosamine-6-sulfate sulfatase in Morquio A syndrome and deficient beta-D-g
Autor:
Harald Hoeger, H. Gialamas, C. Aufricht, Susanne Fang-Kircher, Kurt R. Herkner, Gert Lubec, Adamiker D, Barbara Lubec
Publikováno v:
Europe PubMed Central
In the present study, we tested the hypothesis whether creatine, a metabolite of arginine metabolism, shares the pharmacological activities of arginine reducing collagen accumulation in the diabetic kidney. Ten db/db mice were given, for 3 months, a
Autor:
Harald Hoeger, Susanne Fang-Kircher, Barbara Lubec, Wilhelm Mosgoeller, P Seither, Philomena Kastner, Olga Labudova, Erwin Kitzmueller
Publikováno v:
Pediatric Research. 45:909-909