Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Susanne Eyrisch"'
Autor:
Pamela Brown, Roger Edward Markwell, David L. Downie, Susanne Eyrisch, Neil D. Pearson, Dongzhao Chen, Christopher Barfoot, Stephen Rittenhouse, Graham Elgin Jones, Mark A. Seefeld, Elizabeth A. Minthorn, Jeffrey M. Axten, Steven Dabbs, Alan Joseph Hennessy, Michael N. Gwynn, Gerald Brooks, Jianzhong Huang, Ilaria Giordano, William H. Miller, David T. Davies, Timothy Francis Gallagher, Timothy J. Miles, Jennifer Hoover
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7489-7495
We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c89d8d5098d1fe72b99b9bbcc372d3c
https://doi.org/10.1016/j.bmcl.2011.09.117
https://doi.org/10.1016/j.bmcl.2011.09.117
Autor:
Stephen Rittenhouse, Neil D. Pearson, Christopher Barfoot, Graham Elgin Jones, Timothy J. Miles, David L. Downie, Dongzhao Chen, Steven Dabbs, Jennifer Hoover, Roger Edward Markwell, Alan Joseph Hennessy, Jianzhong Huang, Michael N. Gwynn, Ilaria Giordano, Gerald Brooks, Hong Xiang, David T. Davies, Susanne Eyrisch, Pamela Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7483-7488
As part of our wider efforts to exploit novel mode of action antibacterials, we have discovered a series of cyclohexyl-amide compounds that has good Gram positive and Gram negative potency. The mechanism of action is via inhibition of bacterial topoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3810e692448006878f359f5ce7432ed6
https://doi.org/10.1016/j.bmcl.2011.09.114
https://doi.org/10.1016/j.bmcl.2011.09.114
Publikováno v:
Journal of Molecular Modeling. 18:2031-2042
Protein-protein interactions are abundant in signal transduction pathways and thus of crucial importance in the regulation of apoptosis. However, designing small-molecule inhibitors for these potential drug targets is very challenging as such protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92183410f6da7437204e69ed2e198fc3
https://doi.org/10.1007/s00894-011-1217-y
https://doi.org/10.1007/s00894-011-1217-y
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808:912-924
Protein translocation into the endoplasmic reticulum (ER) is the first and decisive step in the biogenesis of most extracellular and many soluble organelle proteins in eukaryotic cells. It is mechanistically related to protein export from eubacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54fab23df09735c7c409e4c6cce4f7a
https://doi.org/10.1016/j.bbamem.2010.06.015
https://doi.org/10.1016/j.bbamem.2010.06.015
Autor:
Volkhard Helms, Sven Lang, Richard Wagner, Susanne Eyrisch, Martin Jung, Richard Zimmermann, Frank Erdmann
Publikováno v:
FEBS Letters. 583:2359-2364
Previous electrophysiological experiments characterized the Sec61 complex, which provides the aqueous path for entry of newly-synthesized polypeptides into the mammalian endoplasmic reticulum, as a highly dynamic channel that, once activated by precu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5a4fc9993eaf9cb00bff1ac1eb7eb1
https://doi.org/10.1016/j.febslet.2009.06.032
https://doi.org/10.1016/j.febslet.2009.06.032
Autor:
Volkhard Helms, Susanne Eyrisch
Publikováno v:
Journal of Medicinal Chemistry. 50:3457-3464
A new pocket detection protocol successfully identified transient pockets on the protein surfaces of BCL-XL, IL-2, and MDM2. Because the native inhibitor binding pocket was absent or only partly detectable in the unbound proteins, these crystal struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd6835299615d1f85814bbbd837bdfe
https://doi.org/10.1021/jm070095g
https://doi.org/10.1021/jm070095g
Publikováno v:
The Enzymes.
MCP compounds were developed with the idea to inhibit RAS/RAF interaction. They were identified by carrying out high-throughput screens of chemical compounds for their ability to inhibit RAS/RAF interaction in the yeast two-hybrid assay. A number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3562c80eda3355c39ab6876dd750020
https://pubmed.ncbi.nlm.nih.gov/25033807
https://pubmed.ncbi.nlm.nih.gov/25033807
MCP compounds were developed with the idea to inhibit RAS/RAF interaction. They were identified by carrying out high-throughput screens of chemical compounds for their ability to inhibit RAS/RAF interaction in the yeast two-hybrid assay. A number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f07d1e7e55b0513c01ae8abf3780335f
https://doi.org/10.1016/b978-0-12-416749-0.00010-5
https://doi.org/10.1016/b978-0-12-416749-0.00010-5
Publikováno v:
Current pharmaceutical design. 18(30)
The conformational flexibility of protein targets is being increasingly recognized in the drug discovery and design processes. When working on a particular disease-related biochemical pathway, it is of crucial importance to carefully select druggable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7132f8fa727bdac7e8766f7acdd746
https://pubmed.ncbi.nlm.nih.gov/22650258
https://pubmed.ncbi.nlm.nih.gov/22650258
Publikováno v:
Journal of inorganic biochemistry. 104(2)
Modulations of protein–protein interactions are a key step in regulating protein function, especially in networks. Modulators of these interactions are supposed to be candidates for the development of novel drugs. Here, we describe the role of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07871af8db5901a3a44439f36ec40389
https://pubmed.ncbi.nlm.nih.gov/19926138
https://pubmed.ncbi.nlm.nih.gov/19926138