Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Susanne E la Fleur"'
Autor:
José eVan Den Heuvel, Leslie eEggels, Andrea evan Rozen, Eric eFliers, Andries eKalsbeek, Roger eAdan, Susanne E la Fleur
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 9 (2015)
Introduction: Conflicting data exist on sensitivity changes of the melanocortin system during diet-induced obesity. We hypothesized that melanocortin sensitivity depends on diet composition, in particular on the fat content rather than the level of o
Externí odkaz:
https://doaj.org/article/f1109f93adf2456e8afadb8fc9d888d7
Autor:
Judith M Van Der Harg, Leslie eEggels, Silvie R Ruigrok, Jeroen JM Hoozemans, Susanne E la Fleur, Wiep eScheper
Publikováno v:
Frontiers in Neuroscience, Vol 9 (2015)
Abnormal phosphorylation and aggregation of tau is a key hallmark of Alzheimer's disease (AD). AD is a multifactorial neurodegenerative disorder for which Diabetes Mellitus (DM) is a risk factor. In animal models for DM, the phosphorylation and aggre
Externí odkaz:
https://doaj.org/article/068ef56ff2534255b930594cacf0244c
Autor:
Rahul Pandit, Esther M van der Zwaal, Mieneke C M Luijendijk, Maike A D Brans, Andrea J van Rozen, Ralph J A Oude Ophuis, Louk J M J Vanderschuren, Roger A H Adan, Susanne E la Fleur
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121768 (2015)
The role of the melanocortin (MC) system in feeding behavior is well established. Food intake is potently suppressed by central infusion of the MC 3/4 receptor agonist α-melanocyte stimulating hormone (α-MSH), whereas the MC 3/4 receptor inverse-ag
Externí odkaz:
https://doaj.org/article/bfb2daf3a5c54291920b266807b47ab6
Autor:
Nicolette M Lammers, Brigitte M Sondermeijer, Marcel eTwickler, Rob M de Bie, Mariëtte T Ackermans, Eric eFliers, P. Richard Schuurman, Susanne E La Fleur, Mireille J Serlie
Publikováno v:
Frontiers in Neuroscience, Vol 8 (2014)
Animal studies have shown that central dopamine signaling influences glucose metabolism. As a first step to show this association in an experimental setting in humans, we studied whether deep brain stimulation (DBS) of the subthalamic nucleus (STN),
Externí odkaz:
https://doaj.org/article/a413cf2e35324f379cd6375706382560
Autor:
Anke eBorgers, Karin eKoopman, Peter eBisschop, Mireille eSerlie, Dick eSwaab, Eric eFliers, Susanne E La Fleur, Anneke eAlkemade
Publikováno v:
Frontiers in Neuroscience, Vol 8 (2014)
Context: That serotonin plays a role in the regulation of feeding behavior and energy metabolism has been known for a long time. Serotonin transporters (SERT) play a crucial role in serotonin signalling by regulating its availability in the synaptic
Externí odkaz:
https://doaj.org/article/7d39bd9c35414322afc38af53bec7075
Autor:
José K van den Heuvel, Leslie Eggels, Eric Fliers, Andries Kalsbeek, Roger A H Adan, Susanne E la Fleur
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87729 (2014)
ObjectiveLeptin resistance is a common hallmark of obesity. Rats on a free-choice high-fat high-sugar (fcHFHS) diet are resistant to peripherally administered leptin. The aim of this study was to investigate feeding responses to central leptin as wel
Externí odkaz:
https://doaj.org/article/8fc03ba1f2ba4710a08935f928b52dd9
Autor:
Arjen J Boender, Nivard A Koning, José K van den Heuvel, Mieneke C M Luijendijk, Andrea J van Rozen, Susanne E la Fleur, Roger A H Adan
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94159 (2014)
Several genome-wide association studies have implicated the transcription factor E-twenty- six version 5 (Etv5) in the regulation of body mass index. Further substantiating the role of Etv5 in feeding behavior are the findings that targeted disruptio
Externí odkaz:
https://doaj.org/article/067a313c3c09479293230465d6082cf1
Autor:
Charlene eDiepenbroek, Geoffrey evan der Plasse, Leslie eEggels, Merel eRijnsburger, Matthijs eFeenstra, Andries eKalsbeek, Damiaan eDenys, Eric eFliers, Mireille J Serlie, Susanne E la Fleur
Publikováno v:
Frontiers in Neuroscience, Vol 7 (2013)
Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is an effective therapy for obsessive compulsive disorder (OCD) and is currently under investigation as a treatment for eating disorders. DBS of this area is associated with altered food int
Externí odkaz:
https://doaj.org/article/20ad69143a194d6993ce4a24b523adaf
Autor:
Joram D Mul, Susanne E la Fleur, Pim W Toonen, Anthonieke Afrasiab-Middelman, Rob Binnekade, Dustin Schetters, Michel M M Verheij, Robert M Sears, Judith R Homberg, Anton N M Schoffelmeer, Roger A H Adan, Ralph J DiLeone, Taco J De Vries, Edwin Cuppen
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19600 (2011)
Current epidemic obesity levels apply great medical and financial pressure to the strenuous economy of obesity-prone cultures, and neuropeptides involved in body weight regulation are regarded as attractive targets for a possible treatment of obesity
Externí odkaz:
https://doaj.org/article/856a88d2de5d49c7b8dbdde7f3492dfd
Autor:
Margo Slomp, Laura L. Koekkoek, Michael Mutersbaugh, Ian Linville, Serge H. Luquet, Susanne E. la Fleur
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Nutrition can influence the brain and affect its regulation of food intake, especially that of high-palatable foods. We hypothesize that fat and sugar have interacting effects on the brain, and the lateral hypothalamus (LH) is a prime candidate to be
Externí odkaz:
https://doaj.org/article/2a84d59d5483476e9f9ee00c66632764