Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine

Autor: Erik Elias, Arman Ardalan, Markus Lindberg, Susanne E. Reinsbach, Andreas Muth, Ola Nilsson, Yvonne Arvidsson, Erik Larsson

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)

Small intestine neuroendocrine tumors (SI-NETs) are frequently multifocal and metastatic, but their tumourigenesis is still poorly understood. Here, the authors analyse multifocal SI-NET tumours with whole-genome sequencing, revealing the landscape o

Externí odkaz: https://doaj.org/article/123fb58011ff4c5299d20a2fa8383e2b

Metabolic Characterization of Plasma and Cyst Fluid from Cystic Precursors to Pancreatic Cancer Patients Reveal Metabolic Signatures of Bacterial Infection

Autor: Ann Morgell, Roberto Valente, Susanne E Reinsbach, Margaret Chen, Marco Del Chiaro, Angelo D'Alessandro, Asif Halimi, Haleh Davanian, Zeeshan Ateeb, Rogier Aäron Gaiser, Urban Arnelo, Julie A. Reisz

Publikováno v: medRxiv

Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, with a 5-year survival rate as low as 9%. One factor complicating the management of pancreatic cancer is the lack of reliable tools for early diagnosis. While up to 50%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8a294cbbe5623f5c5eb11243ee290b
https://doi.org/10.1021/acs.jproteome.1c00018

Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions

Autor: Haleh Davanian, Margaret Chen, Soo Aleman, Anthony T. Tan, Katie Healy, Antonio Bertoletti, Andrea Pavesi, Tiphaine Parrot, Johan K. Sandberg, Susanne E Reinsbach, Michał J. Sobkowiak

Publikováno v: JHEP Reports, Vol 3, Iss 4, Pp 100318-(2021)
JHEP Reports

Background & Aims Virus-specific T cell dysfunction is a common feature of HBV-related hepatocellular carcinoma (HBV-HCC). Conventional T (ConT) cells can be redirected towards viral antigens in HBV-HCC when they express an HBV-specific receptor; how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd0342307cbb74465ae0246e43031e6
https://doi.org/10.1016/j.jhepr.2021.100318

Interplay of microRNAs, transcription factors and target genes: linking dynamic expression changes to function

Autor: Arnaud Muller, Stephanie Kreis, Nathalie Nicot, Laurent Vallar, Demetra Philippidou, Susanne E. Reinsbach, Petr V. Nazarov

Publikováno v: Nucleic Acids Research

MicroRNAs (miRNAs) are ubiquitously expressed small non-coding RNAs that, in most cases, negatively regulate gene expression at the post-transcriptional level. miRNAs are involved in fine-tuning fundamental cellular processes such as proliferation, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911ac84580edf6edcf87e1a499c1008f
http://europepmc.org/articles/PMC3597666

Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells

Autor: Susanne E. Reinsbach, Dorothee Nashan, Martina Schmitt, Christiane Margue, Iris Behrmann, Anke Wienecke-Baldacchino, Demetra Philippidou, Stephanie Kreis

Publikováno v: Cell Communication and Signaling, 10. BioMed Central (2012).
Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 10, Iss 1, p 41 (2012)

Background The type-II-cytokine IFN-γ is a pivotal player in innate immune responses but also assumes functions in controlling tumor cell growth by orchestrating cellular responses against neoplastic cells. The role of IFN-γ in melanoma is not full

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8554365e0d0206422303c6641a2fcc06
https://doi.org/10.1186/1478-811x-10-41