Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Susanne Bredenberg"'
Publikováno v:
International Journal of Pharmaceutics. 488:102-107
With the increasing number of misuse and abuse of opioids, the resistance to tampering becomes an important attribute for transdermal opioid patches. In this study, drug-containing geopolymer granules were integrated into an adhesive matrix to improv
Publikováno v:
International Journal of Pharmaceutics. 465:169-174
Tamper-resistance is an important property of controlled-release formulations of opioid drugs. Tamper-resistant formulations aim to increase the degree of effort required to override the controlled release of the drug molecules from extended-release
Publikováno v:
Pain Research and Treatment, Vol 2012 (2012)
Pain Research and Treatment
Pain Research and Treatment
In vitro drug release tests are a widely used tool to measure the variance between transdermal product performances and required by many authorities. However, the result cannot provide a good estimation of the in vivo drug release. In the present wor
Publikováno v:
Journal of Pharmaceutical Sciences. 101:1803-1810
This study investigates the influence of drug solubility and distribution on its release from inert geopolymer pellets of three different sizes (1.5 × 1.5, 3 × 6, and 6 × 6 mm), having the same geopolymer composition and containing highly potent o
Publikováno v:
Results in Pharma Sciences. 2:23-28
Improving acid resistance, while maintaining the excellent mechanical stability is crucial in the development of a sustained and safe oral geopolymer dosage form for highly potent opioids. In the present work, commercially available Methacrylic acid
Publikováno v:
Journal of Controlled Release. 146:370-377
We propose that a clay derived class of materials, known as geopolymers, may solve the problem of finding materials for controlled release with the right combination of properties necessary for a safe and sustained oral delivery of highly potent opio
Publikováno v:
Journal of Pharmaceutical Sciences. 99:219-226
Pellets composed of the ceramic material Halloysite and microcrystalline cellulose were synthesized with the aim of producing a drug delivery vehicle for sustained release of the opioid Fentanyl with low risk for dose dumping at oral intake of the hi
Publikováno v:
Pharmaceutical Research. 26:1618-1625
To create improved pharmaceutical formulations for nasal and sublingual administration of desmopressin and investigate their pharmacokinetic profiles in comparison with a commercial nasal liquid spray and finally to evaluate the volunteers' opinions
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 94
To reduce the effort required to penetrate the skin and optimize drug release profiles, bioceramic microneedle arrays with higher-aspect-ratio needles and a flexible and self-swelling substrate have been developed. Swelling of the substrate can assis
Autor:
Hans Lennernäs, M Holmberg, Bo Lennernäs, Christer Nyström, Thomas Hedner, Susanne Bredenberg
Publikováno v:
British Journal of Clinical Pharmacology. 59:249-253
It is estimated that two-thirds of cancer patients will at some point during their illness experience breakthrough pain. In this study, the pharmacokinetics of a novel sublingual dosage form of fentanyl developed for breakthrough pain was evaluated.E