Výsledky vyhledávání - "Susanne Bonsmann"

First‐in‐Human, Single‐ and Multiple‐Ascending‐Dose, Food‐Effect, and Absolute Bioavailability Trials to Assess the Pharmacokinetics, Safety, and Tolerability of Pritelivir, a Nonnucleoside Helicase‐Primase Inhibitor Against Herpes Simplex Virus in Healthy Subjects

Autor: Dirk Kropeit, Susanne Bonsmann, Oliver von Richter, David McCormick, Jörg Pausch, Melanie Sumner, Alexander Birkmann, Holger Zimmermann, Helga Rübsamen‐Schaeff

Publikováno v: Clinical Pharmacology in Drug Development.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c5887c1fe383470f851d2912aa34596
https://doi.org/10.1002/cpdd.1241

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Discovery, Chemistry, and Preclinical Development of Pritelivir, a Novel Treatment Option for Acyclovir-Resistant Herpes Simplex Virus Infections

Autor: Alexander Birkmann, Susanne Bonsmann, Dirk Kropeit, Tamara Pfaff, Manickam Rangaraju, Melanie Sumner, Burkhard Timmler, Holger Zimmermann, Helmut Buschmann, Helga Ruebsamen-Schaeff

Publikováno v: Journal of medicinal chemistry. 65(20)

When the nucleoside analogue acyclovir was introduced in the early 1980s, it presented a game-changing treatment modality for herpes simplex virus infections. Since then, work has been ongoing to improve the weaknesses that have now been identified:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69be1720a16217550c44fc70babd502
https://pubmed.ncbi.nlm.nih.gov/36202389

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Assessing Pharmacokinetics of Various Dosage Forms at Early Stage

Autor: Susanne Bonsmann, Joachim Ossig

Publikováno v: Innovative Dosage Forms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b2c66a450c2ce022f23d9e41e6c6c69
https://doi.org/10.1002/9783527812172.ch7

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Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis

Autor: Debra C. Quenelle, Thomas Goldner, Alexander Birkmann, Tamara Pfaff, Holger Zimmermann, Terri L. Rice, Mark N. Prichard, Deborah J. Collins, Susanne Bonsmann

Publikováno v: Antiviral Research. 149:1-6

Pritelivir, a helicase-primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV type 1 or 2, including acyclovir-resistant strains, were treated 72 h after infection for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10120bfa283164eed57cc592845c456c
https://doi.org/10.1016/j.antiviral.2017.11.002

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