Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Susanne Billmann-Born"'
Autor:
Konrad Aden, Ateequr Rehman, Maren Falk-Paulsen, Thomas Secher, Jan Kuiper, Florian Tran, Steffen Pfeuffer, Raheleh Sheibani-Tezerji, Alexandra Breuer, Anne Luzius, Marlene Jentzsch, Robert Häsler, Susanne Billmann-Born, Olga Will, Simone Lipinski, Richa Bharti, Timon Adolph, Juan L. Iovanna, Sarah L. Kempster, Richard S. Blumberg, Stefan Schreiber, Burkhard Becher, Mathias Chamaillard, Arthur Kaser, Philip Rosenstiel
Publikováno v:
Cell Reports, Vol 16, Iss 8, Pp 2208-2218 (2016)
A plethora of functional and genetic studies have suggested a key role for the IL-23 pathway in chronic intestinal inflammation. Currently, pathogenic actions of IL-23 have been ascribed to specific effects on immune cells. Herein, we unveil a protec
Externí odkaz:
https://doaj.org/article/c7ad691214884543bd2eb9b5ed88874d
Autor:
Simone Lipinski, Konrad Aden, Mohamed Lamkanfi, Till Strowig, Christian Treitz, Henriette Ebsen, Anne Luzius, Nicolas Gisch, Susanne Billmann-Born, Philipp Arnold, Philip Rosenstiel, Stefan Schreiber, Hans-Dietmar Beer, Maren Falk-Paulsen, Jan W. P. Kuiper, Andreas Tholey, Steffen Pfeuffer, Antonella Fazio, Gabriel Núñez
Publikováno v:
The EMBO Journal
EMBO JOURNAL
The EMBO journal
EMBO JOURNAL
The EMBO journal
Inflammasomes are cytosolic protein complexes, which orchestrate the maturation of active IL-1 beta by proteolytic cleavage via caspase-1. Although many principles of inflammasome activation have been described, mechanisms that limit inflammasome-dep
Autor:
Gunnar Jacobs, Simone Lipinski, Konrad Aden, Susanne Billmann-Born, Alexander Arlt, Nils Grabe, Stefan Schreiber, Kai S. Erdmann, Robert Häsler, Nina Hagemann, Philip Rosenstiel, Andreas Till, Maren Paulsen, Lars Kraemer
Publikováno v:
Proceedings of the National Academy of Sciences. 109:21426-21431
The intracellular nucleotide-binding oligomerization domain-2 (NOD2) receptor detects bacteria-derived muramyl dipeptide (MDP) and activates the transcription factor NF-κB. Here we describe the regulatome of NOD2 signaling using a systematic RNAi sc
Autor:
John C. Reed, Britt-Sabina Petersen, Susanne Billmann-Born, Christoph Röcken, Andreas Keller, Martin Schrappe, Philip Rosenstiel, Martin W. Laass, Jelka Hartwig, Alfred C. Feller, Martina Kohl, Heide Brandau, Snezana Milutinovic, Kenneth Peuker, Stefan Schreiber, Andre Franke, Sebastian Zeissig, Yvonne Zeissig, Esther Bosse, Gabriele Mayr
Publikováno v:
Gut. 64(1)
Objective The genetic basis of inflammatory bowel disease (IBD) is incompletely understood. The aim of this study was to identify rare genetic variants involved in the pathogenesis of IBD. Design Exome sequencing and immunological profiling were perf
Autor:
Lukas Niederreiter, Eduardo Martínez-Naves, Arthur Kaser, Stefan Schreiber, Susanne Billmann-Born, John H. Hartwig, Hyun-Jeong Ko, Jennifer L. Cusick, Magdalena B. Flak, Philip Rosenstiel, Timon E. Adolph, Tim Raine, Richa Bharti, Richard S. Blumberg, Stefan J. Marciniak, Janne Böck, Michal Tomczak, Jonathan N. Glickman, Mi-Na Kweon, Augustine M.K. Choi, Takao Iwawaki, Shuhei Hosomi, Susan J. Hagen, Kenji Kohno, Ralph Lucius, Markus Tschurtschenthaler
Publikováno v:
Nature
The recognition of autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly prevalent ATG16L1 risk allele, or murine hypomorphic (HM) activity, causes Pa
Autor:
Simone Lipinski, Thomas Manke, Stefan Schreiber, Christian Sina, Andreas Till, Jun Li, Susanne Billmann-Born, David A. van Heel, Adedayo Hanidu, Philip Rosenstiel, Vito Annese, Dirk Seegert, Anna Latiano, Martin Kerick, Robert Häsler, Alexander Arlt, Heiner Schäfer
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 186(7)
NOD2 is an intracellular receptor for the bacterial cell wall component muramyl dipeptide (MDP), and variants of NOD2 are associated with chronic inflammatory diseases of barrier organs (e. g., Crohn's disease, asthma, and atopic eczema). It is known
Autor:
Stefan Schreiber, Janne Böck, Andreas Till, Philip Rosenstiel, Susanne Billmann-Born, Simone Lipinski
Publikováno v:
European journal of cell biology. 90(6-7)
Several coding variants of NOD2 and ATG16L1 are associated with increased risk of Crohn disease (CD). NOD2, a cytosolic receptor of the innate immune system activates pro-inflammatory signalling cascades upon recognition of bacterial muramyl dipeptid
Autor:
Maren Falk-Paulsen, Jan W. P. Kuiper, Richard S. Blumberg, Florian Tran, Timon E. Adolph, Alexandra Breuer, Anne Luzius, Thomas Secher, Ateequr Rehman, Arthur Kaser, Philip Rosenstiel, Steffen Pfeuffer, Marlene Jentzsch, Olga Will, Konrad Aden, Sarah L. Kempster, Mathias Chamaillard, Richa Bharti, Susanne Billmann-Born, Stefan Schreiber, Robert Häsler, Simone Lipinski, Raheleh Sheibani-Tezerji, Burkhard Becher, Juan L. Iovanna
Publikováno v:
Cell Reports
Cell Reports, Vol 16, Iss 8, Pp 2208-2218 (2016)
Cell Reports, Vol 16, Iss 8, Pp 2208-2218 (2016)
A plethora of functional and genetic studies have suggested a key role for the IL-23 pathway in chronic intestinal inflammation. Currently, pathogenic actions of IL-23 have been ascribed to specific effects on immune cells. Herein, we unveil a protec