Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Susanne Berglund"'
Autor:
Magnus Nilsson, Magdalena Rhedin, Ramon Hendrickx, Susanne Berglund, Antonio Piras, Parmis Blomgran, Anders Cavallin, Mia Collins, Göran Dahl, Bilel Dekkak, Therese Ericsson, Niklas Hagberg, Ann Aurell Holmberg, Agnes Leffler, Anders J Lundqvist, Thomais Markou, James Pinkerton, Lars Rönnblom, Stacey Siu, Vanessa Taylor, Tiiu Wennberg, Dimitrios Zervas, Arian D J Laurence, Suman Mitra, Maria G Belvisi, Mark Birrell, Annika Borde
Publikováno v:
Drug Design, Development and Therapy. 16:2901-2917
Magnus Nilsson,1 Magdalena Rhedin,2 Ramon Hendrickx,3 Susanne Berglund,1 Antonio Piras,2 Parmis Blomgran,2 Anders Cavallin,2 Mia Collins,2 Göran Dahl,4 Bilel Dekkak,5 Therese Ericsson,3 Niklas Hagberg,6 Ann Aurell Holmberg,3 Agnes Leffler,2 Anders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0c74bc776adaba8bf5ad2a70652436
https://doi.org/10.2147/dddt.s354291
https://doi.org/10.2147/dddt.s354291
Publikováno v:
ACS Combinatorial Science. 14:304-308
A modular synthesis of P-chirogenic α-alkoxyphosphine ligands has been developed, allowing for the variation of two of the three groups on phosphorus. Oxidation and concomitant desymmetrization of a prochiral alkyl- or aryldimethylphosphine borane a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7a5cc5e4b589691aa15b341c111f33
https://doi.org/10.1021/co2002119
https://doi.org/10.1021/co2002119
Autor:
Joakim Gradén, Fabrizio Giordanetto, David G.A. Morgan, Susanne Berglund, Tord Inghardt, Henrik Gradén, Bryan J. Egner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4859-4863
A series of 1,3-disubstituted-1H-pyrrole-based antagonists of the human Melanin-Concentrating Hormone Receptor 1 (h-MCH-R1) are reported. High-throughput screening of the AstraZeneca compound collection yielded 1, a hit with moderate affinity towards
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e706826b82ff3b5ef39d588b64df78de
https://doi.org/10.1016/j.bmcl.2008.07.079
https://doi.org/10.1016/j.bmcl.2008.07.079
Autor:
Jan Lindberg, Olle Karlsson, Karl Edman, Tord Inghardt, Susanne Berglund, Barlaam Bernard Christophe, Fabrizio Giordanetto, Sven Nylander
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(16)
Optimization of AZD6482 (2), the first antiplatelet PI3Kβ inhibitor evaluated in man, focused on improving the pharmacokinetic profile to a level compatible with once daily oral dosing as well as achieving adequate selectivity towards PI3Kα to mini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270d1330819bc9c91a82fabfba24ec25
https://pubmed.ncbi.nlm.nih.gov/25042253
https://pubmed.ncbi.nlm.nih.gov/25042253
Autor:
Bryan J. Egner, Joakim Gradén, Henrik Gradén, Fabrizio Giordanetto, Susanne Berglund, Tord Inghardt, David G.A. Morgan
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
Herein, we disclose the discovery and optimization of 2-piperidin-4-yl-acetamide derivatives as MCH-R1 antagonists. Structural investigation of piperidin-4-yl-amide and piperidin-4-yl-ureas identified 2-piperidin-4-yl-acetamide-based MCH-R1 antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4501b99a603df4fd34de67daccf032
https://pubmed.ncbi.nlm.nih.gov/19500979
https://pubmed.ncbi.nlm.nih.gov/19500979
Autor:
Bryan J. Egner, David G.A. Morgan, Joakim Gradén, Fabrizio Giordanetto, Henrik Gradén, Susanne Berglund, Tord Inghardt
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
The discovery and optimization of piperidin-4-yl-urea derivatives as MCH-R1 antagonists is herein described. Previous work around the piperidin-4-yl-amides led to the discovery of potent MCH-R1 antagonists. However, high affinity towards the hERG pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c9f30d39f5c207d6b9e353044bdf0f
https://pubmed.ncbi.nlm.nih.gov/19500982
https://pubmed.ncbi.nlm.nih.gov/19500982