Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Susanne Badura"'
Autor:
Fabian Lang, Lydia Wunderle, Susanne Badura, Eberhard Schleyer, Monika Brüggemann, Hubert Serve, Susanne Schnittger, Nicola Gökbuget, Heike Pfeifer, Sebastian Wagner, Kevin Ashelford, Gesine Bug, Oliver G. Ottmann
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Combined inhibition of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) complexes may be an efficient treatment for acute leukemia. The primary objective of this phase I single center open label st
Externí odkaz:
https://doaj.org/article/feda2fbc95de41e789dcb412107b0d8e
Autor:
Özlem Demirel, Olivier Balló, Pavankumar N G Reddy, Olesya Vakhrusheva, Jing Zhang, Astrid Eichler, Ramona Fernandes, Susanne Badura, Hubert Serve, Christian Brandts
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180401 (2017)
Treatment with tyrosine kinase inhibitors is the standard of care for Philadelphia chromosome positive leukemias. However the eradication of leukemia initiating cells remains a challenge. Circumstantial evidence suggests that the cytokine microenviro
Externí odkaz:
https://doaj.org/article/04ca4e4f9e9043d9854c72e793296f83
Autor:
Susanne Badura, Tamara Tesanovic, Heike Pfeifer, Sylvia Wystub, Bart A Nijmeijer, Marcus Liebermann, J H Frederik Falkenburg, Martin Ruthardt, Oliver G Ottmann
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80070 (2013)
PurposeAberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase
Externí odkaz:
https://doaj.org/article/8be4fcff685f4559b7a75dabb1fd3081
Autor:
Susanne Badura, Juliane Wagner, Hans G. Klingemann, Peter Bader, Oliver G. Ottmann, Miriam E. Friede, Sarah Oelsner, Torsten Tonn, Winfried S. Wels, Evelyn Ullrich, Congcong Zhang
Publikováno v:
Cytotherapy. 19:235-249
Background aims\ud \ud Natural killer (NK) cells can rapidly respond to transformed and stressed cells and represent an important effector cell type for adoptive immunotherapy. In addition to donor-derived primary NK cells, continuously expanding cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f91d312b8c0c7b9ac1b93470965291
https://doi.org/10.1016/j.jcyt.2016.10.009
https://doi.org/10.1016/j.jcyt.2016.10.009
Autor:
Oliver G. Ottmann, Andreas Borowski, Nilabh Ranjan, Michael Kuepper, Karlheinz Friedrich, Tina Vetter, Andreas Wohlmann, Susanne Badura
Publikováno v:
Leukemia research. 40
PURPOSE: The cytokine thymic stromal lymphopoietin (TSLP) and its receptor TSLPR are involved in intercellular communication in the course of allergic inflammation and have recently been implicated in the development of various malignancies including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62434396fd97ac3b8610def183c0daa2
https://pubmed.ncbi.nlm.nih.gov/26652578
https://pubmed.ncbi.nlm.nih.gov/26652578
Publikováno v:
Biochemical and Biophysical Research Communications. 349:1329-1338
The p53-inducible and death domain-containing PIDD/LRDD protein has been described as an adaptor protein, which forms large protein complexes with RAIDD, another death domain-containing protein, leading to recruitment, and activation of the initiator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0970f7e047c2e7685e171951bff1f6a9
https://doi.org/10.1016/j.bbrc.2006.08.176
https://doi.org/10.1016/j.bbrc.2006.08.176
Autor:
Ramona Gomes Fernandes, Olesya Vakhrusheva, Christian Brandts, Jing Zhang, Hubert Serve, Susanne Badura, Olivier Ballo, Astrid Eichler, Pavankumar N. G. Reddy, Özlem Demirel
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180401 (2017)
PLoS ONE
PLoS ONE
Treatment with tyrosine kinase inhibitors is the standard of care for Philadelphia chromosome positive leukemias. However the eradication of leukemia initiating cells remains a challenge. Circumstantial evidence suggests that the cytokine microenviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cad08ea21ab4177e12b9e5f08b1b649
https://doi.org/10.1371/journal.pone.0180401
https://doi.org/10.1371/journal.pone.0180401
Autor:
Heike Pfeifer, Susanne Badura, Sylvia Wystub, Marcus Liebermann, J.H. Frederik Falkenburg, Bart A. Nijmeijer, Martin Ruthardt, Tamara Tesanovic, Oliver G. Ottmann
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80070 (2013)
PLoS ONE
PLoS ONE, 8(11)
PLoS ONE
PLoS ONE, 8(11)
PurposeAberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f17fbc1f5d343b1738bf5fa5f7ae4a
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244612/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244612/?tool=EBI
Autor:
Thomas Oellerich, Oliver G. Ottmann, Susanne Badura, Tamara Tesanovic, Martin Ruthardt, Claudia Doering
Publikováno v:
Blood. 124:3595-3595
The development of small molecules targeting oncogenic signaling pathways as treatment for leukemias has focused on inhibitors of tyrosine kinases. Subtypes of acute leukemias harboring aberrant fusion genes that involve transcription factors rather
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9148a62484f0181f7e76b83dc57bd0e
https://doi.org/10.1182/blood.v124.21.3595.3595
https://doi.org/10.1182/blood.v124.21.3595.3595
Autor:
Susanne Badura, Oliver G. Ottmann, Michael A. Rieger, Monika Brüggemann, Thomas Oellerich, Tamara Tesanovic, Timm Schroeder, Anja Vogel, J.H. Frederik Falkenburg, Fabian Lang, Bartosch Wojcik
Publikováno v:
Blood. 124:3778-3778
Introduction: Transforming events in B-lineage (ALL) occur primarily at the level of committed progenitor cells, but the phenotype, frequency and hierarchical organization of leukemia-initiating cells (LICs) are controversial. Pronounced clonal heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d01ebd615ad3d43d41d4dd9230f0bb37
https://doi.org/10.1182/blood.v124.21.3778.3778
https://doi.org/10.1182/blood.v124.21.3778.3778