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pro vyhledávání: '"Susanne Aleth"'
Publikováno v:
Journal of Cardiovascular Pharmacology. 48:820-826
Transgenic mice are often used to study the physiologic role of a known gene. The design of experiments with transgenic mice usually does not take into account strain and sex differences, at least in isolated vessels. Therefore, we have compared the
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 366:562-569
Smooth muscle contraction is primarily regulated by reversible phosphorylation of the 20-kDa light chains of myosin (MLC(20)) involving Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) and serine/threonine protein phosphatases (PP). The a
Autor:
Maren Wellner, Wilhelm Schmitz, Susanne Aleth, Stephanie Grote, Thomas Podzuweit, Hermann Haller, Joachim Neumann, Vera Samoilova, Igor B. Buchwalow, Werner Boecker
Publikováno v:
Nitric oxide : biology and chemistry. 10(4)
The concept of endothelium derived relaxing factor (EDRF) implies that nitric oxide (NO) generated by NO synthase in the endothelium diffuses to the underlying vascular smooth muscle cells (VSMC) modulating thereby vascular tone. VSMC were regarded a