Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Susanne A. Hahn"'
Autor:
Sven Fridrich, Susanne A Hahn, Marion Linzmaier, Matthias Felten, Jenny Zwarg, Volker Lennerz, Andrea Tuettenberg, Walter Stöcker
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153290 (2016)
GARP (glycoprotein A repetitions predominant) is a cell surface receptor on regulatory T-lymphocytes, platelets, hepatic stellate cells and certain cancer cells. Its described function is the binding and accommodation of latent TGFβ (transforming gr
Externí odkaz:
https://doaj.org/article/2f1c9f35cd4642a2bdc8532e5a94da9e
Autor:
Andrea Tuettenberg, Susanne A Hahn, Johanna Mazur, Aslihan Gerhold-Ay, Jetse Scholma, Iris Marg, Alexander Ulges, Kazuki Satoh, Tobias Bopp, Jos Joore, Helmut Jonuleit
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149193 (2016)
Regulatory T cells (Treg) are essential for T cell homeostasis and maintenance of peripheral tolerance. They prevent activation of auto-reactive T effector cells (Teff) in the context of autoimmunity and allergy. Otherwise, Treg also inhibit effectiv
Externí odkaz:
https://doaj.org/article/f21ed477c60c446fbfa47524dbc9c07a
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Regulatory T cells (Treg) control immune cell function as well as non-immunological processes. Their far-reaching regulatory activities suggest their functional manipulation as a means to sustainably and causally intervene with the course of diseases
Externí odkaz:
https://doaj.org/article/d2ab13eb1aac4b95a3a6c756364d4f09
Autor:
Hendrik Beckert, Sebastian Reuter, Christian Becker, Roland Buhl, Helmut Jonuleit, Susanne A. Hahn, Stephanie Korn, Helen Meyer-Martin, Andrea Tuettenberg, C Belz, Christian Taube, Andreas Heinz
Publikováno v:
Allergy, 71(9), 1274-1283
Background Regulatory T cells (Treg) represent a promising target for novel treatment strategies in patients with inflammatory/allergic diseases. A soluble derivate of the Treg surface molecule glycoprotein A repetitions predominant (sGARP) has stron
Autor:
Heiko Stahl, Susanne A. Hahn, Franz-Joseph Schneider, Christian Becker, Helmut Jonuleit, Andrea Tuettenberg, Anita Correll
Publikováno v:
Blood. 122:1182-1191
Glycoprotein A repetitions predominant (GARP) is expressed on the surface of activated human regulatory T cells (Treg) and regulates the bioavailability of transforming growth factor-β (TGF-β). GARP has been assumed to require membrane anchoring. T
Autor:
Stephan Grabbe, Thomas Tueting, Jonathan Schupp, Susanne A. Hahn, Annemarie Neuhoff, Volker Lennerz, Jenny Landsberg, Detlef Schuppan, Daniela Eberts, Petra Leukel, Andrea Tuettenberg, Matthias Bros, Helmut Jonuleit, Clemens Sommer, Martin Weilbaecher
Publikováno v:
Oncotarget
In melanoma patients, one of the main reasons for tumor immune escape and therapy failure is the immunosuppressive tumor microenvironment. Herein, suppressive immune cells and inhibitory factors secreted by the tumor itself play a central role. In th
Autor:
Helen Meyer-Martin, Petra Scholtes, Susanne A. Hahn, Hendrik Beckert, Christian Becker, Joachim Maxeiner, Andrea Tüttenberg, Roland Buhl, Helmut Jonuleit, Christian Taube, Stephanie Korn, Sebastian Reuter
Publikováno v:
5.3 Allergy and Immunology.
Soluble derivate of Glycoprotein A repetitions predominant (sGARP) has strong anti-inflammatory and regulatory properties in vitro as well as in vivo , represses proliferation and cytokine production of CD4 + T helper cells and induces CD4 + regulato
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Frontiers in Immunology
Frontiers in Immunology
Regulatory T cells (Treg) control immune cell function as well as non-immunological processes. Their far-reaching regulatory activities suggest their functional manipulation as a means to sustainably and causally intervene with the course of diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb9c2f0bc80b4d501c97cc36469010f
Publikováno v:
Cytokine. 70:43-44
TGF- β is a highly pleiotropic cytokine and a well-known suppressor of inflammatory T cells. Dysregulation in TGF- β function is associated with multiple pathological phenomenons including tumor cell growth, fibrosis and autoimmunity. GARP (glycopr