Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Susanne Flor"'
Publikováno v:
Cell Stress, Vol 6, Iss 4, Pp 45-60 (2022)
Glioblastoma (GBM) is a fatal disease with recurrences often associated with radioresistance. Although often effective at treating newly diagnosed GBM, increasing evidence suggests that radiotherapy-induced alterations in tumor metabolism promote GBM
Externí odkaz:
https://doaj.org/article/8c00afdcd8c1420bbb9f2be14bd325be
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 349 (2023)
Median overall survival is very low in patients with glioblastoma (GBM), largely because these tumors become resistant to therapy. Recently, we found that a decrease in the cytosolic labile iron pool underlies the acquisition of radioresistance. Both
Externí odkaz:
https://doaj.org/article/38cd6d7a56464c7b847b993479868298
Publikováno v:
Cells, Vol 11, Iss 21, p 3464 (2022)
Iron is essential for many cellular processes, but cellular iron homeostasis must be maintained to ensure the balance of cellular signaling processes and prevent disease. Iron transport in and out of the cell and cellular organelles is crucial in thi
Externí odkaz:
https://doaj.org/article/c20f76f8dab04376bf94be96a6eff363
Publikováno v:
Metabolites, Vol 12, Iss 8, p 748 (2022)
Although often effective at treating newly diagnosed glioblastoma (GBM), increasing evidence suggests that chemo- and radiotherapy-induced alterations in tumor metabolism promote GBM recurrence and aggressiveness, as well as treatment resistance. Rec
Externí odkaz:
https://doaj.org/article/8bc07d1da2354a4f8eb659b36ef5dbcb
Autor:
Susanne Flor, Claudia R. Oliva, Md Yousuf Ali, Kristen L. Coleman, Jeremy D. Greenlee, Karra A. Jones, Varun Monga, Corinne E. Griguer
Publikováno v:
Antioxidants, Vol 10, Iss 12, p 1988 (2021)
Glioblastoma remains the deadliest form of brain cancer, largely because these tumors become resistant to standard of care treatment with radiation and chemotherapy. Intracellular production of reactive oxygen species (ROS) is necessary for chemo- an
Externí odkaz:
https://doaj.org/article/e470bfc0424d4aeaa02e4939e1e2ef87
Autor:
Chun-Yun Zhang, Xueshu Li, Susanne Flor, Patricia Ruiz, Anneli Kruve, Gabriele Ludewig, Hans-Joachim Lehmler
Publikováno v:
Environmental Science & Technology. 56:12460-12472
Lower chlorinated polychlorinated biphenyls (LC-PCBs) and their metabolites make up a class of environmental pollutants implicated in a range of adverse outcomes in humans; however, the metabolism of LC-PCBs in human models has received little attent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b17c56d7928702c40295971bfb9ff11
https://doi.org/10.1021/acs.est.2c03687
https://doi.org/10.1021/acs.est.2c03687
Publikováno v:
Free Radical Biology and Medicine. 185:25-35
Radiotherapy is an important treatment modality for glioblastoma (GBM), yet the initial effectiveness of radiotherapy is eventually lost due to the development of adaptive radioresistance during fractionated radiation therapy. Defining the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1c3b3c8d107066c08e4dbb5222095f
https://doi.org/10.1016/j.freeradbiomed.2022.04.012
https://doi.org/10.1016/j.freeradbiomed.2022.04.012
Publikováno v:
Environmental Science & Technology
The characterization of the metabolism of lower chlorinated PCB, such as 4-chlorobiphenyl (PCB3), is challenging because of the complex metabolite mixtures formed in vitro and in vivo. We performed parallel metabolism studies with PCB3 and its hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63f35ec51465442dc5a46b47b5b5c67
https://doi.org/10.1021/acs.est.1c01076
https://doi.org/10.1021/acs.est.1c01076
TMET-15. CYTOCHROME C OXIDASE MEDIATES CELLULAR IRON HOMEOSTASIS AND RADIORESISTANCE IN GLIOBLASTOMA
Publikováno v:
Neuro-Oncology. 24:vii264-vii265
Defining the molecular mechanism(s) responsible for the adaptive radioresistance in glioblastoma (GBM) is necessary for the development of effective treatment options. The cellular labile iron pool (LIP) is very important for determining the cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb12bb671e3e053d06668ee7667b56ed
https://doi.org/10.1093/neuonc/noac209.1020
https://doi.org/10.1093/neuonc/noac209.1020
Autor:
Katherine N. Gibson-Corley, Nazmin Eti, Regan L. Scott, Violet E Klenov, Michael J. Soares, Khursheed Iqbal, Gabriele Ludewig, Susanne Flor, Larry W. Robertson
Publikováno v:
Toxicology
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the regulation of biological responses to more planar aromatic hydrocarbons, like TCDD. We previously described the sequence of events following exposure of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe38a24137ed615df65f511e04398dc1
https://europepmc.org/articles/PMC8748418/
https://europepmc.org/articles/PMC8748418/
