Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Susanne, Unger"'
Autor:
Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Cornelius Miething, Uta S. Martens, Khalid Shoumariyeh, Rosa P. Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R. Blazar, Burkhard Becher, Melanie Boerries, Robert Zeiser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Patients with corticosteroid-refractory acute graft-versus-host disease (aGVHD) have a low one-year survival rate. Identification and validation of novel targetable kinases in patients who experience corticosteroid-refractory-aGVHD may help
Externí odkaz:
https://doaj.org/article/cb63dbf7545c4a79898fb5a39c9842f1
Autor:
Stefanie Kreutmair, Maximilian Schaefer, Sebastian Stolz, Carla Merten, Can Ulutekin, Tobias Wertheimer, Florian Ingelfinger, Susanne Unger, Chiara Alberti, Aakriti Sethi, Markus Manz, Thorsten Zenz, Antonia Müller, Corinne Widmer, Burkhard Becher
Publikováno v:
HemaSphere, Vol 7, p e12648f2 (2023)
Externí odkaz:
https://doaj.org/article/025887b144af4b40ababde6f454fde1b
Autor:
Pauline van Schouwenburg, Susanne Unger, Kathryn J. Payne, Fabian M. P. Kaiser, Ingrid Pico-Knijnenburg, Jens Pfeiffer, Oliver Hausmann, David Friedmann, Michelle Erbel, Maximilian Seidl, David van Zessen, Andrew P. Stubbs, Mirjam van der Burg, Klaus Warnatz
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Common variable immunodeficiency (CVID), characterized by recurrent infections, low serum class-switched immunoglobulin isotypes, and poor antigen-specific antibody responses, comprises a heterogeneous patient population in terms of clinical presenta
Externí odkaz:
https://doaj.org/article/003fd5f0403547f692216d98a57c9ffd
Autor:
Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niemeyer, Miriam Erlacher, Bruce R. Blazar, Burkard Becher, Olaf Groß, Tilman Brummer, Robert Zeiser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3
Externí odkaz:
https://doaj.org/article/8d60e15645a540748f0978aece6a6bc5
Autor:
David Friedmann, Susanne Unger, Baerbel Keller, Mirzokhid Rakhmanov, Sigune Goldacker, Gernot Zissel, Björn C. Frye, Jonas C. Schupp, Antje Prasse, Klaus Warnatz
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
BackgroundAbout 20% of patients with common variable immunodeficiency (CVID) suffer from interstitial lung disease (ILD) as part of a systemic immune dysregulation. Current understanding suggests a role of B cells in the pathogenesis based on histolo
Externí odkaz:
https://doaj.org/article/2d72ebbf203a4996a4791a32189b6f6f
Autor:
Julian Staniek, Raquel Lorenzetti, Bianca Heller, Iga Janowska, Pascal Schneider, Susanne Unger, Klaus Warnatz, Maximilian Seidl, Nils Venhoff, Jens Thiel, Cristian Roberto Smulski, Marta Rizzi
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The maintenance of B cell homeostasis requires a tight control of B cell generation, survival, activation, and maturation. In lymphocytes upon activation, increased sensitivity to apoptotic signals helps controlling differentiation and proliferation.
Externí odkaz:
https://doaj.org/article/3433b0c3a7be4af5b2b580b839f14fd1
Autor:
Christian Klemann, Nadezhda Camacho-Ordonez, Linlin Yang, Zoya Eskandarian, Jessica L. Rojas-Restrepo, Natalie Frede, Alla Bulashevska, Maximilian Heeg, Moudjahed Saleh Al-Ddafari, Julian Premm, Maximilian Seidl, Sandra Ammann, Roya Sherkat, Nita Radhakrishnan, Klaus Warnatz, Susanne Unger, Robin Kobbe, Anja Hüfner, T. Ronan Leahy, Winnie Ip, Siobhan O. Burns, Manfred Fliegauf, Bodo Grimbacher
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous mutations in NFKB2 have recently been established as a molecular cause of common variable immunodeficiency (CVID) and DAVID-syndrome, a rare condition combining defi
Externí odkaz:
https://doaj.org/article/a2fc5ecf9ac44a21a75172989f793db7
Autor:
Sinduya Krishnarajah, Florian Ingelfinger, Ekaterina Friebel, Dilay Cansever, Ana Amorim, Myrto Andreadou, David Bamert, Gioana Litscher, Mirjam Lutz, Maud Mayoux, Sarah Mundt, Frederike Ridder, Colin Sparano, Sebastian Anton Stifter, Can Ulutekin, Susanne Unger, Marijne Vermeer, Pascale Zwicky, Melanie Greter, Sonia Tugues, Donatella De Feo, Burkhard Becher
Publikováno v:
Nature Aging. 2:74-89
Autor:
Adam Klocperk, Zuzana Paračková, Markéta Bloomfield, Michal Rataj, Jan Pokorný, Susanne Unger, Klaus Warnatz, Anna Šedivá
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
DiGeorge syndrome is an immunodeficiency characterized by thymic dysplasia resulting in T cell lymphopenia. Most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, such as autoimmune thrombo
Externí odkaz:
https://doaj.org/article/17b08f0a4c7043ab9f9316b0e975da5d
Autor:
Stefanie Kreutmair, Maximilian M Schaefer, Sebastian Stolz, Carla Merten, Can Ulutekin, Florian Ingelfinger, Susanne Unger, Chiara Alberti, Tobias Wertheimer, Aakriti Sethi, Thorsten Zenz, Markus G Manz, Antonia Maria Susanne Müller, Corinne C Widmer, Burkhard Becher
Publikováno v:
Blood. 140:7504-7505