Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Susanne, Sebens"'
Autor:
Saumil Shah, Lisa-Marie Philipp, Stefano Giaimo, Susanne Sebens, Arne Traulsen, Michael Raatz
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Cancer metastasis is the process of detrimental systemic spread and the primary cause of cancer-related fatalities. Successful metastasis formation requires tumor cells to be proliferative and invasive; however, cells cannot be effective at
Externí odkaz:
https://doaj.org/article/146bd285ae564c5b8e029c2c96bf5ff2
Autor:
Katharina Staufer, Heidemarie Huber, Jasmin Zessner-Spitzenberg, Rudolf Stauber, Armin Finkenstedt, Heike Bantel, Thomas S. Weiss, Markus Huber, Patrick Starlinger, Thomas Gruenberger, Thomas Reiberger, Susanne Sebens, Gail McIntyre, Ray Tabibiazar, Amato Giaccia, Heinz Zoller, Michael Trauner, Wolfgang Mikulits
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract The expression of the receptor tyrosine kinase Axl and its cleavage product soluble Axl (sAxl) is increased in liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). In this multicenter study, we evaluated the diagnostic value of Gas
Externí odkaz:
https://doaj.org/article/6ec11fb752674d009f3b4dccfb87f223
Autor:
Sandra Genduso, Vera Freytag, Daniela Schetler, Lennart Kirchner, Alina Schiecke, Hanna Maar, Daniel Wicklein, Florian Gebauer, Katharina Bröker, Christine Stürken, Karin Milde-Langosch, Leticia Oliveira-Ferrer, Franz L. Ricklefs, Florian Ewald, Gerrit Wolters-Eisfeld, Kristoffer Riecken, Ludmilla Unrau, Linda Krause, Hanibal Bohnenberger, Anne Offermann, Sven Perner, Susanne Sebens, Katrin Lamszus, Linda Diehl, Stefan Linder, Manfred Jücker, Udo Schumacher, Tobias Lange
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-24 (2023)
Abstract Background The immunological composition of the tumor microenvironment has a decisive influence on the biological course of cancer and is therefore of profound clinical relevance. In this study, we analyzed the cooperative effects of integri
Externí odkaz:
https://doaj.org/article/15a2e60098c04388b2f1c864ee3b2031
Autor:
Tina Daunke, Silje Beckinger, Sascha Rahn, Sandra Krüger, Steffen Heckl, Heiner Schäfer, Daniela Wesch, Christian Pilarsky, Markus Eckstein, Arndt Hartmann, Christoph Röcken, Anna Maxi Wandmacher, Susanne Sebens
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionImmune checkpoint inhibitors (ICI), e.g., targeting programmed cell death protein 1-ligand 1 (PD-L1) or its receptor PD-1, have markedly improved the therapy of many cancers but so far failed in pancreatic ductal adenocarcinoma (PDAC). Ma
Externí odkaz:
https://doaj.org/article/f2babd76fb144183893834bce80fb625
Autor:
Silje Beckinger, Tina Daunke, Leon Aldag, Sandra Krüger, Steffen Heckl, Daniela Wesch, Heiner Schäfer, Christoph Röcken, Sascha Rahn, Susanne Sebens
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionPancreatic ductal adenocarcinoma (PDAC) represents the 4th most common cause of cancer-related deaths in Western countries. Most patients are diagnosed at advanced stages, often already with metastases. The main site of metastasis is the
Externí odkaz:
https://doaj.org/article/817692eed56944a0ad4bfc2a431adf27
Autor:
Nourhane Ammar, Maya Hildebrandt, Claudia Geismann, Christian Röder, Timo Gemoll, Susanne Sebens, Ania Trauzold, Heiner Schäfer
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1818 (2023)
Metabolic compartmentalization of stroma-rich tumors, like pancreatic ductal adenocarcinoma (PDAC), greatly contributes to malignancy. This involves cancer cells importing lactate from the microenvironment (reverse Warburg cells) through monocarboxyl
Externí odkaz:
https://doaj.org/article/3f337b46b0c8422fa790dcd023bbceb6
Autor:
Dennis Gürgen, Theresia Conrad, Michael Becker, Susanne Sebens, Christoph Röcken, Jens Hoffmann, Stefan Langhammer
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
The identification of novel therapeutic strategies for advanced non-small cell lung cancer (NSCLC) is essential as the outcome of most of these patients is poor. Here the authors provide a proof-of concept that specific low-dose drug combinations can
Externí odkaz:
https://doaj.org/article/92f28987a8ba465c999b6d45aa1fdeb2
Autor:
Florian Richter, Clara Henssen, Tim Alexander Steiert, Tobias Meissner, Anne-Sophie Mehdorn, Christoph Röcken, Andre Franke, Jan-Hendrik Egberts, Thomas Becker, Susanne Sebens, Michael Forster
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10673 (2023)
Esophageal cancer (EC) has one of the highest mortality rates among cancers, making it imperative that therapies are optimized and dynamically adapted to individuals. In this regard, liquid biopsy is an increasingly important method for residual dise
Externí odkaz:
https://doaj.org/article/38241694d50b4b818ec07b8bb30ed137
Autor:
Antoine M. Dujon, Athena Aktipis, Catherine Alix‐Panabières, Sarah R. Amend, Amy M. Boddy, Joel S. Brown, Jean‐Pascal Capp, James DeGregori, Paul Ewald, Robert Gatenby, Marco Gerlinger, Mathieu Giraudeau, Rodrigo K. Hamede, Elsa Hansen, Irina Kareva, Carlo C. Maley, Andriy Marusyk, Nicholas McGranahan, Michael J. Metzger, Aurora M. Nedelcu, Robert Noble, Leonard Nunney, Kenneth J. Pienta, Kornelia Polyak, Pascal Pujol, Andrew F. Read, Benjamin Roche, Susanne Sebens, Eric Solary, Kateřina Staňková, Holly Swain Ewald, Frédéric Thomas, Beata Ujvari
Publikováno v:
Evolutionary Applications, Vol 14, Iss 4, Pp 877-892 (2021)
Abstract The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years. Following the initial theoretical approach
Externí odkaz:
https://doaj.org/article/89d15c8bc6dc4e8fb594eb56f0fd801f
Autor:
Dana Hellmold, Carolin Kubelt, Tina Daunke, Silje Beckinger, Ottmar Janssen, Margarethe Hauck, Fabian Schütt, Rainer Adelung, Ralph Lucius, Jochen Haag, Susanne Sebens, Michael Synowitz, Janka Held-Feindt
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 9075 (2023)
Glioblastoma (GBM) is a poorly treatable disease due to the fast development of tumor recurrences and high resistance to chemo- and radiotherapy. To overcome the highly adaptive behavior of GBMs, especially multimodal therapeutic approaches also incl
Externí odkaz:
https://doaj.org/article/199fcdc621684944a5fa575830945d1e