Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Susanne, Rinné"'
Autor:
Lea C. Neelsen, Elena B. Riel, Susanne Rinné, Freya-Rebecca Schmid, Björn C. Jürs, Mauricio Bedoya, Jan P. Langer, Bisher Eymsh, Aytug K. Kiper, Sönke Cordeiro, Niels Decher, Thomas Baukrowitz, Marcus Schewe
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Two-pore domain K+ (K2P) channel activity was previously thought to be controlled primarily via a selectivity filter (SF) gate. However, recent crystal structures of TASK-1 and TASK-2 revealed a lower gate at the cytoplasmic pore entrance. H
Externí odkaz:
https://doaj.org/article/24e90c44b7b6404d984bf10fe4b40d18
Autor:
Susanne Rinné, Florian Schick, Kirsty Vowinkel, Sven Schütte, Cornelius Krasel, Silke Kauferstein, Martin K.-H. Schäfer, Aytug K. Kiper, Thomas Müller, Niels Decher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract TASK-5 (KCNK15) belongs to the acid-sensitive subfamily of two-pore domain potassium (K2P) channels, which includes TASK-1 and TASK-3. TASK-5 stands out as K2P channel for which there is no functional data available, since it was reported in
Externí odkaz:
https://doaj.org/article/b17c857dbfc94fcaa4432f3f85b28b22
Autor:
Felix P. Bernhard, Sven Schütte, Moritz Heidenblut, Moritz Oehme, Susanne Rinné, Niels Decher
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Potassium channel mutations play an important role in neurological diseases, such as spinocerebellar ataxia (SCA). SCA is a heterogeneous autosomal-dominant neurodegenerative disorder with multiple sub-entities, such as SCA13, which is characterized
Externí odkaz:
https://doaj.org/article/4d8a875cb22245c8b1fb63d635085c5e
Autor:
Susanne Rinné, Aytug K. Kiper, Ralf Jacob, Beatriz Ortiz-Bonnin, Roland F.R. Schindler, Sabine Fischer, Marlene Komadowski, Emilia De Martino, Martin K.-H. Schäfer, Tamina Cornelius, Larissa Fabritz, Christian S.M. Helker, Thomas Brand, Niels Decher
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109696- (2024)
Summary: Popeye domain containing (POPDC) proteins are predominantly expressed in the heart and skeletal muscle, modulating the K2P potassium channel TREK-1 in a cAMP-dependent manner. POPDC1 and POPDC2 variants cause cardiac conduction disorders wit
Externí odkaz:
https://doaj.org/article/1ce96870dcd649eb8224595e7a24a264
Autor:
Alexander H. Swan, Roland F. R. Schindler, Marco Savarese, Isabelle Mayer, Susanne Rinné, Felix Bleser, Anne Schänzer, Andreas Hahn, Mario Sabatelli, Francesco Perna, Kathryn Chapman, Mark Pfuhl, Alan C. Spivey, Niels Decher, Bjarne Udd, Giorgio Tasca, Thomas Brand
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-25 (2023)
Abstract The Popeye domain containing (POPDC) genes encode sarcolemma-localized cAMP effector proteins. Mutations in blood vessel epicardial substance (BVES) also known as POPDC1 and POPDC2 have been associated with limb-girdle muscular dystrophy and
Externí odkaz:
https://doaj.org/article/09d556ac95ca4f42ac1341a433d746fc
Autor:
Alba Vera-Zambrano, Maria Baena-Nuevo, Susanne Rinné, Marta Villegas-Esguevillas, Bianca Barreira, Gokcen Telli, Angela de Benito-Bueno, José Antonio Blázquez, Belén Climent, Francisco Pérez-Vizcaino, Carmen Valenzuela, Niels Decher, Teresa Gonzalez, Angel Cogolludo
Publikováno v:
Pharmacological Research, Vol 189, Iss , Pp 106684- (2023)
KV1.5 channels are key players in the regulation of vascular tone and atrial excitability and their impairment is associated with cardiovascular diseases including pulmonary arterial hypertension (PAH) and atrial fibrillation (AF). Unfortunately, pha
Externí odkaz:
https://doaj.org/article/669cefd33c57474f939a3f93d47c212f
Autor:
Alexander H. Swan, Roland F. R. Schindler, Marco Savarese, Isabelle Mayer, Susanne Rinné, Felix Bleser, Anne Schänzer, Andreas Hahn, Mario Sabatelli, Francesco Perna, Kathryn Chapman, Mark Pfuhl, Alan C. Spivey, Niels Decher, Bjarne Udd, Giorgio Tasca, Thomas Brand
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/99db98333bdf412ea91af94fccfd7441
Autor:
Lina A. Matschke, Marlene A. Komadowski, Annette Stöhr, Bolam Lee, Martin T. Henrich, Markus Griesbach, Susanne Rinné, Fanni F. Geibl, Wei-Hua Chiu, James B. Koprich, Jonathan M. Brotchie, Aytug K. Kiper, Amalia M. Dolga, Wolfgang H. Oertel, Niels Decher
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Parkinson’s disease (PD) is clinically defined by the presence of the cardinal motor symptoms, which are associated with a loss of dopaminergic nigrostriatal neurons in the substantia nigra pars compacta (SNpc). While SNpc neurons serve as
Externí odkaz:
https://doaj.org/article/b4c64fe5027f4227873cb7742ebf70c7
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss S3, Pp 87-107 (2021)
Externí odkaz:
https://doaj.org/article/13bb2fb2883b4813a12778fd77c3e0c9
Autor:
Alejandro Valdés-Jiménez, Daniel Jiménez-González, Aytug K. Kiper, Susanne Rinné, Niels Decher, Wendy González, Miguel Reyes-Parada, Gabriel Núñez-Vivanco
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The identification of similar three-dimensional (3D) amino acid patterns among different proteins might be helpful to explain the polypharmacological profile of many currently used drugs. Also, it would be a reasonable first step for the design of no
Externí odkaz:
https://doaj.org/article/197170dac86541658f2b64ec95dd9c6f