Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Susanne, Raulefs"'
Autor:
Ziying Jian, Tao Cheng, Zhiheng Zhang, Susanne Raulefs, Kuangyu Shi, Katja Steiger, Nadja Maeritz, Karin Kleigrewe, Thomas Hofmann, Simone Benitz, Philipp Bruns, Daniel Lamp, Martin Jastroch, Jan Akkan, Carsten Jäger, Peilin Huang, Shuang Nie, Shanshan Shen, Xiaoping Zou, Güralp O. Ceyhan, Christoph W. Michalski, Helmut Friess, Jörg Kleeff, Bo Kong
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 4, Pp 429-449 (2018)
Background & Aims: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mech
Externí odkaz:
https://doaj.org/article/a2ff2b7c8a4e4563ac1a648e6adcb65c
Autor:
Georg Leinenkugel, Bo Kong, Susanne Raulefs, Katharina Miller, Susanne Roth, Hongdie Jiang, Rouzanna Istvánffy, Hanna Heikenwälder, Nadja Maeritz, Ivonne Regel, Ivane Abiatari, Jörg Kleeff, Christoph W. Michalski, Simon Rieder
Sca-1 is a surface marker for murine hematopoietic stem cells (HSCs) and type-I interferon is a key regulator for LinTo characterize Sca-1 in vivo, immunohistochemistry and immunofluorescence staining of Sca-1 was conducted in normal pancreas, in cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c0630b41aa95b58c93a4e1f2f4af40
Autor:
Katharina J Miller, Susanne Raulefs, Bo Kong, Katja Steiger, Ivonne Regel, Andreas Gewies, Jörg Kleeff, Christoph W Michalski
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143735 (2015)
Type I interferon constitutes an essential component of the combinational therapy against viral disease. Acute pancreatitis is one side effect of type I interferon-based therapy, implying that activation of type I interferon signaling affects the hom
Externí odkaz:
https://doaj.org/article/df282f41aae54b7db2f3c2ae22113df6
Autor:
Güralp O. Ceyhan, Helmut Friess, Anna Melissa Schlitter, Zhiheng Zhang, Katja Steiger, Susanne Raulefs, Shanshan Shen, Tao Cheng, Yamin Zhao, Jörg Kleeff, Ziying Jian, Nadja Maeritz, Christoph W. Michalski, Bo Kong, Xiaoping Zou
Publikováno v:
International Journal of Cancer. 144:2529-2538
Pancreatitis is a significant risk factor for pancreatic ductal adenocarcinoma (PDAC). Previous studies in mice have demonstrated that pancreatitis contributes to oncogenic Kras-driven carcinogenesis, probably initiated in acinar cells; however, onco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ecf0bf82b759ccbf2fd1ba52d02f7c
https://doi.org/10.1002/ijc.31981
https://doi.org/10.1002/ijc.31981
Autor:
Susanne Raulefs, Zhiheng Zhang, Jörg Kleeff, Vanesa Fernández-Sáiz, Torsten Hechler, Guosheng Wang, Xiaoping Zou, Yuan Wan, Hongzhen Li, Helmut Friess, Hana Algül, Thomas Engleitner, Shanshan Shen, Christoph W. Michalski, Kalliope N. Diakopoulos, Yuanyuan Yu, Andre Mihaljevic, Yibin Deng, Roland Rad, Kathleen Schuck, Nadja Maeritz, Bo Kong, Maximilian Reichert, Verena Weber, Jingjing Li, Andreas Pahl, Rupert Öllinger
Publikováno v:
Gastroenterology. 161(5)
Background & Aims Promoted by pancreatitis, oncogenic KrasG12D triggers acinar cells' neoplastic transformation through acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia. Anterior gradient 2 (Agr2), a known inhibitor of p53,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48295f7e92200b3ed808a455d0c804a9
https://pubmed.ncbi.nlm.nih.gov/34303658
https://pubmed.ncbi.nlm.nih.gov/34303658
Autor:
Zhiheng Zhang, Jörg Kleeff, Nadja Maeritz, Susanne Raulefs, Xiaoping Zou, Helmut Friess, Christina Ludwig, Dianbo Yao, Kathleen Schuck, Metello Innocenti, Yamin Zhao, Shanshan Shen, Vivien Tissen, Achim Krüger, Christoph W. Michalski, Jan G. D’Haese, Rob A. van der Kammen, Carsten Jäger, Benjamin Schoeps, Anna Melissa Schlitter, Bo Kong
Background & Aims Oncogenic KrasG12D induces neoplastic transformation of pancreatic acinar cells through acinar-to-ductal metaplasia (ADM), an actin-based morphogenetic process, and drives pancreatic ductal adenocarcinoma (PDAC). mTOR (mechanistic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba34c09707c2496b2d8d168be927eda2
https://hdl.handle.net/10281/396252
https://hdl.handle.net/10281/396252
Autor:
Susanne Raulefs, Lily Nguyen, Michael W. Pfaffl, Sophie Dobiasch, Stephanie E. Combs, Thomas Schmid, Daniela Schilling, Dominik Buschmann, Marina Franco
Publikováno v:
Cancers
Volume 12
Issue 12
Cancers, Vol 12, Iss 3703, p 3703 (2020)
Cancers 12:3703 (2020)
Volume 12
Issue 12
Cancers, Vol 12, Iss 3703, p 3703 (2020)
Cancers 12:3703 (2020)
Today, pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide with a five-year overall survival rate of less than 7%. Only 15&ndash
20% of patients are eligible for curative intent surgery at the time of diagnosis. The
20% of patients are eligible for curative intent surgery at the time of diagnosis. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e17abca079462b1b2a6d0c3968cfc5
Autor:
Yamin, Zhao, Benjamin, Schoeps, Dianbo, Yao, Zhiheng, Zhang, Kathleen, Schuck, Vivien, Tissen, Carsten, Jäger, Anna Melissa, Schlitter, Rob, van der Kammen, Christina, Ludwig, Jan G, D'Haese, Susanne, Raulefs, Nadja, Maeritz, Shanshan, Shen, Xiaoping, Zou, Achim, Krüger, Jörg, Kleeff, Christoph W, Michalski, Helmut, Friess, Metello, Innocenti, Bo, Kong
Publikováno v:
Gastroenterology. 160(5)
Oncogenic KrasA mouse model of inflammation-accelerated KrasWe found that mTORC1 and mTORC2 are markedly activated in human and mouse ADM lesions, and cooperate to promote KrasHere, we show that mTORC1 and mTORC2 attain a dual, yet nonredundant regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4560c9a27e846ea57221b61a92f95f35
https://pubmed.ncbi.nlm.nih.gov/33388318
https://pubmed.ncbi.nlm.nih.gov/33388318
Autor:
Susanne Raulefs, Shanshan Shen, Katja Steiger, Daniel Lamp, Kuangyu Shi, Jan Akkan, Helmut Friess, Christoph W. Michalski, Nadja Maeritz, Jörg Kleeff, Philipp Bruns, Bo Kong, Shuang Nie, Tao Cheng, Martin Jastroch, Güralp O. Ceyhan, Simone Benitz, Thomas Hofmann, Xiaoping Zou, Ziying Jian, Carsten Jäger, Karin Kleigrewe, Peilin Huang, Zhiheng Zhang
Publikováno v:
Cell. Mol. Gast. Hept. 6, 429-449 (2018)
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 4, Pp 429-449 (2018)
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 4, Pp 429-449 (2018)
Background & Aims: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e92c70ed437f3a4572f524b1dbc099
https://doi.org/10.1016/j.jcmgh.2018.07.003
https://doi.org/10.1016/j.jcmgh.2018.07.003
Autor:
Stefan Czemmel, Katja Steiger, Julia Mayerle, Ivonne Regel, Tatjana Unruh, Jörg Kleeff, Susanne Raulefs, Christoph W. Michalski, Irene Esposito, Britta Wingerath, Güralp O. Ceyhan, Simone Benitz, Bo Kong, Francisco X. Real, Sven Nahnsen, Sabrina Deubler
Publikováno v:
Zeitschrift für Gastroenterologie. 55:e1-e27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de214bb27c23078b983d68818f978c66
https://doi.org/10.1055/s-0037-1603059
https://doi.org/10.1055/s-0037-1603059