Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation

Autor: Shishan Wang, Marie-Laure Fogeron, Maarten Schledorn, Marie Dujardin, Susanne Penzel, Dara Burdette, Jan Martin Berke, Michael Nassal, Lauriane Lecoq, Beat H. Meier, Anja Böckmann

Publikováno v: Frontiers in Molecular Biosciences, Vol 6 (2019)

Modulation of capsid assembly by small molecules has become a central concept in the fight against viral infection. Proper capsid assembly is crucial to form the high molecular weight structures that protect the viral genome and that, often in concer

Externí odkaz: https://doaj.org/article/f3ba5dd1450b4b619e4a96f9091e6647

Dimer Organization of Membrane-Associated NS5A of Hepatitis C Virus as Determined by Highly Sensitive 1 H-Detected Solid-State NMR

Autor: Alexander A. Malär, Alons Lends, Susanne Penzel, Anja Böckmann, Ralf Bartenschlager, Beat H. Meier, Vlastimil Jirasko, Marco E. Weber, Marie-Laure Fogeron, Nils-Alexander Lakomek

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, 60 (10), pp.5339-5347. ⟨10.1002/anie.202013296⟩
Angewandte Chemie

International audience; The Hepatitis C virus nonstructural protein 5A (NS5A) is a membrane-associated protein involved in multiple steps of the viral life cycle. Direct-acting antivirals (DAAs) targeting NS5A are a cornerstone of antiviral therapy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0fa34117977f0fffbeab0a07130c3d
https://hal.archives-ouvertes.fr/hal-03366997/document

Protein NMR Spectroscopy at 150 kHz Magic-Angle Spinning Continues To Improve Resolution and Mass Sensitivity

Autor: Mai-Liis Org, Daniel Klose, Beat H. Meier, Maarten Schledorn, Alexander A. Malär, Lauriane Lecoq, Susanne Penzel, Shishan Wang, Ago Samoson, Anja Böckmann, Anahit Torosyan, Andres Oss, Riccardo Cadalbert

Publikováno v: ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2020, 21, pp.2540-2548. ⟨10.1002/cbic.202000341⟩
ChemBioChem, 21 (17)
Chembiochem

Spectral resolution is the key to unleashing the structural and dynamic information contained in NMR spectra. Fast magic‐angle spinning (MAS) has recently revolutionized the spectroscopy of biomolecular solids. Herein, we report a further remarkabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55420f50039696d2b90d56c0aca00052
https://pubmed.ncbi.nlm.nih.gov/32501630

Strukturelle Untersuchung subviraler Partikel durch die Kombination von zellfreier Proteinherstellung mit 110 kHz MAS‐NMR‐Spektroskopie

Autor: Susanne Penzel, Michael Nassal, Uta Haselmann, Marie-Laure Fogeron, Anja Böckmann, Aurélie Badillo, Maarten Schledorn, Ralf Bartenschlager, Roland Montserret, Patrice Andre, Lauriane Lecoq, Guillaume David, Beat H. Meier

Publikováno v: Angewandte Chemie. 130:4877-4882

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b74aa9c534e61575c454777fda75123d
https://doi.org/10.1002/ange.201712091

Structural Studies of Self-Assembled Subviral Particles: Combining Cell-Free Expression with 110 kHz MAS NMR Spectroscopy

Autor: Uta Haselmann, Lauriane Lecoq, Roland Montserret, Marie-Laure Fogeron, Ralf Bartenschlager, Aurélie Badillo, Susanne Penzel, Maarten Schledorn, Patrice Andre, Beat H. Meier, Anja Böckmann, Guillaume David, Michael Nassal

Publikováno v: Angewandte Chemie. International Edition, 57 (17)
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2018, 57 (17), pp.4787-4791. ⟨10.1002/anie.201712091⟩

Angewandte Chemie. International Edition, 57 (17)
ISSN:1433-7851
ISSN:1521-3773
ISSN:0570-0833

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0694199599213714be223213c8ffa14b