Aging-regulated TUG1 is dispensable for endothelial cell function.

Autor: Anna Theresa Gimbel, Susanne Koziarek, Kosta Theodorou, Jana Felicitas Schulz, Laura Stanicek, Veerle Kremer, Tamer Ali, Stefan Günther, Sandeep Kumar, Hanjoong Jo, Norbert Hübner, Lars Maegdefessel, Stefanie Dimmeler, Sebastiaan van Heesch, Reinier A Boon

Publikováno v: PLoS ONE, Vol 17, Iss 9, p e0265160 (2022)

The evolutionary conserved Taurine Upregulated Gene 1 (TUG1) is a ubiquitously expressed gene that is one of the highest expressed genes in human and rodent endothelial cells (ECs). We here show that TUG1 expression decreases significantly in aging m

Externí odkaz: https://doaj.org/article/3a8fbf0914984d0ea15f7b0c39b7157a

Neuro-oncological Ventral Antigen 2 Regulates Splicing of Vascular Endothelial Growth Factor Receptor 1 and Is Required for Endothelial Function

Autor: Veerle Kremer, Jetta J. Oppelaar, Theresa Gimbel, Susanne Koziarek, Wessel Ganzevoort, Mariëlle G. van Pampus, Bert-Jan van den Born, Liffert Vogt, Christianne de Groot, Reinier A. Boon

Publikováno v: Reproductive Sciences. SAGE Publications Inc.
Reproductive sciences (Thousand Oaks, Calif.). SAGE Publications Inc.
Kremer, V, Oppelaar, J J, Gimbel, T, Koziarek, S, Ganzevoort, W, van Pampus, M G, van den Born, B-J, Vogt, L, de Groot, C & Boon, R A 2022, ' Neuro-oncological Ventral Antigen 2 Regulates Splicing of Vascular Endothelial Growth Factor Receptor 1 and Is Required for Endothelial Function ', Reproductive Sciences . https://doi.org/10.1007/s43032-022-01044-4

AbstractPre-eclampsia (PE) affects 2–8% of pregnancies and is responsible for significant morbidity and mortality. The maternal clinical syndrome (defined by hypertension, proteinuria, and organ dysfunction) is the result of endothelial dysfunction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8fe74859fdb57b62a711806c13f581
https://research.vumc.nl/en/publications/047a43d6-475f-42cb-b84b-1c7add0c6627