Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Susanne, Kossatz"'
Autor:
Sabrina Marcazzan, Marcos J. Braz Carvalho, Nghia T. Nguyen, Julia Strangmann, Julia Slotta-Huspenina, Anna Tenditnaya, Markus Tschurtschenthaler, Jonas Rieder, Andrea Proaño-Vasco, Vasilis Ntziachristos, Katja Steiger, Dimitris Gorpas, Michael Quante, Susanne Kossatz
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background Esophageal cancer is one of the 10 most common cancers worldwide and its incidence is dramatically increasing. Despite some improvements, the current surveillance protocol with white light endoscopy and random untargeted biopsies
Externí odkaz:
https://doaj.org/article/ff6d310172284ca49bcfc681bab115a2
Autor:
Le Zhang, Matthias Wirth, Upayan Patra, Jacob Stroh, Konstandina Isaakidis, Leonie Rieger, Susanne Kossatz, Maja Milanovic, Chuanbing Zang, Uta Demel, Jan Keiten‐Schmitz, Kristina Wagner, Katja Steiger, Roland Rad, Florian Bassermann, Stefan Müller, Ulrich Keller, Markus Schick
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-19 (2023)
Abstract The DNA damage response (DDR) acts as a barrier to malignant transformation and is often impaired during tumorigenesis. Exploiting the impaired DDR can be a promising therapeutic strategy; however, the mechanisms of inactivation and correspo
Externí odkaz:
https://doaj.org/article/836a10a55ed242399020398764bfdb7f
Autor:
Lea Jessica Flitsch, Kathleen Börner, Christian Stüllein, Simon Ziegler, Vera Sonntag-Buck, Ellen Wiedtke, Vesselina Semkova, Si Wah Christina Au Yeung, Julia Schlee, Mohamad Hajo, Mona Mathews, Beatrice Stefanie Ludwig, Susanne Kossatz, Horst Kessler, Dirk Grimm, Oliver Brüstle
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Human brain cells generated by in vitro cell programming provide exciting prospects for disease modeling, drug discovery and cell therapy. These applications frequently require efficient and clinically compliant tools for genetic modificatio
Externí odkaz:
https://doaj.org/article/4875817cf7bc4d6497c93a0dff7c11d4
Autor:
Katja Steiger, Neil Gerard Quigley, Tanja Groll, Frauke Richter, Maximilian Alexander Zierke, Ambros Johannes Beer, Wilko Weichert, Markus Schwaiger, Susanne Kossatz, Johannes Notni
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Background In the context of nuclear medicine and theranostics, integrin-related research and development was, for most of the time, focused predominantly on 'RGD peptides' and the subtype αvβ3-integrin. However, there are no less than 24
Externí odkaz:
https://doaj.org/article/ddacefd1bb7641c186cf43f929006c12
Autor:
Patrick L. Donabedian, Susanne Kossatz, John A. Engelbach, Stephen A. Jannetti, Brandon Carney, Robert J. Young, Wolfgang A. Weber, Joel R. Garbow, Thomas Reiner
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Background Radiation injury can be indistinguishable from recurrent tumor on standard imaging. Current protocols for this differential diagnosis require one or more follow-up imaging studies, long dynamic acquisitions, or complex image post-
Externí odkaz:
https://doaj.org/article/3f947d958e0241a2a07b1ad001ca3df4
Autor:
Brandon Carney, Susanne Kossatz, Benjamin H. Lok, Valentina Schneeberger, Kishore K. Gangangari, Naga Vara Kishore Pillarsetty, Wolfgang A. Weber, Charles M. Rudin, John T. Poirier, Thomas Reiner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Treatment of small-cell lung cancer remains a challenge due to multiple mechanisms of resistance to current therapies; measuring patient response is crucial in adapting and choosing adequate treatment. Here the authors develop a strategy to visualise
Externí odkaz:
https://doaj.org/article/e625a8f0d4ae4e3f93d027d2afb43df5
Autor:
Ali Azhdarinia, William E. Fisher, Sadhna Dhingra, Thomas Reiner, Jo Simien, Hop S. Tran Cao, Sukhen C. Ghosh, Julie Voss, Susanne Kossatz, Servando Hernandez Vargas
Purpose:Clinically available intraoperative imaging tools to assist surgeons in identifying occult lesions are limited and partially responsible for the high rate of disease recurrence in patients with neuroendocrine tumors (NET). Using the establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67e8b97ecb6756723c38a253b85590a
https://doi.org/10.1158/1078-0432.c.6527807.v1
https://doi.org/10.1158/1078-0432.c.6527807.v1
Autor:
Thomas Reiner, Mark M. Souweidane, Wolfgang A. Weber, David Pisapia, Kayvan R. Keshari, Prajwal Rajappa, Uday B. Maachani, Vesselin Z. Miloushev, Giuseppe Carlucci, Melanie Schweitzer, Brandon Carney, Susanne Kossatz
Monitoring tumor growth using [18F]PARPi. Display of weekly imaging of tumor development in adult ntv-a;p53fl/fl mice at the indicated time after DF1 cell injection. PET/CT imaging was always conducted 2 h p.i. of [18F]PARPi. Animals were sacrificed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4b045090394ce35e9570ea1c0e71a8
https://doi.org/10.1158/0008-5472.22416185
https://doi.org/10.1158/0008-5472.22416185
Autor:
Thomas Reiner, John L. Humm, Jason S. Lewis, Brian M. Zeglis, Masatomo Maeda, Paula Demétrio De Souza França, Navjot Guru, Susanne Kossatz, Ahmad Sadique, Lukas M. Carter, Stephen A. Jannetti, Giacomo Pirovano
Purpose:Glioblastoma multiforme is a highly aggressive form of brain cancer whose location, tendency to infiltrate healthy surrounding tissue, and heterogeneity significantly limit survival, with scant progress having been made in recent decades.Expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3d84d435e71e8fffa5b72e04fb0beb
https://doi.org/10.1158/1078-0432.c.6529175
https://doi.org/10.1158/1078-0432.c.6529175
Autor:
Thomas Reiner, Mark M. Souweidane, Wolfgang A. Weber, David Pisapia, Kayvan R. Keshari, Prajwal Rajappa, Uday B. Maachani, Vesselin Z. Miloushev, Giuseppe Carlucci, Melanie Schweitzer, Brandon Carney, Susanne Kossatz
Chemical structures of PARPi-FL and [18F]PARPi. We developed a fluorescent ("PARPi-FL") (a) and 18F-labelled ("[18F]PARPi") (b) version of a PARP1 targeted small molecule, based on the structure of Olaparib23, 26, 27. Mouse and human PARP1 are orthol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d16a7aed988747ebb0102a116adacd
https://doi.org/10.1158/0008-5472.22416200.v1
https://doi.org/10.1158/0008-5472.22416200.v1