Intravenous and oral copper kinetics, biodistribution and dosimetry in healthy humans studied by [64Cu]copper PET/CT

Autor: Kristoffer Kjærgaard, Thomas Damgaard Sandahl, Kim Frisch, Karina Højrup Vase, Susanne Keiding, Hendrik Vilstrup, Peter Ott, Lars Christian Gormsen, Ole Lajord Munk

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-12 (2020)

Abstract Purpose Copper is essential for enzymatic processes throughout the body. [64Cu]copper (64Cu) positron emission tomography (PET) has been investigated as a diagnostic tool for certain malignancies, but has not yet been used to study copper ho

Externí odkaz: https://doaj.org/article/dd82fbacf7f940ed95a27aa3e162b337

Metabolic liver function in humans measured by 2-18F-fluoro-2-deoxy-D-galactose PET/CT–reproducibility and clinical potential

Autor: Kirstine P. Bak-Fredslund, Peter Lykke Eriksen, Ole L. Munk, Gerda E. Villadsen, Susanne Keiding, Michael Sørensen

Publikováno v: EJNMMI Research, Vol 7, Iss 1, Pp 1-7 (2017)

Abstract Background PET/CT with the radioactively labelled galactose analogue 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) can be used to quantify the hepatic metabolic function and visualise regional metabolic heterogeneity. We determined the day-to

Externí odkaz: https://doaj.org/article/16f261b05f324cc5aec723776eaa7c52

The pathophysiology of Wilson’s disease visualized: A human 64Cu PET study

Autor: Ditte Emilie Munk, Lars C. Gormsen, Susanne Keiding, Ole Lajord Munk, Karina H. Vase, Hendrik Vilstrup, Thomas Damgaard Sandahl, Kim Frisch, Peter Ott, Dirk Bender, Mikkel H. Vendelbo, Kristoffer Kjærgaard

Publikováno v: Sandahl, T D, Gormsen, L C, Kjaergaard, K, Vendelbo, M H, Munk, D E, Munk, O L, Bender, D, Keiding, S, Vase, K H, Frisch, K, Vilstrup, H & Ott, P 2021, ' The pathophysiology of Wilson disease visualised : A human 64 Cu PET study ', Hepatology . https://doi.org/10.1002/hep.32238
Sandahl, T D, Gormsen, L C, Kjærgaard, K, Vendelbo, M, Munk, D E, Munk, O L, Bender, D, Keiding, S, Vase, K H, Frisch, K, Vilstrup, H V A & Ott, P 2022, ' The pathophysiology of Wilson’s disease visualized : A human 64 Cu PET study ', Hepatology, vol. 75, no. 6, pp. 1461-1470 . https://doi.org/10.1002/hep.32238

BACKGROUND & AIMS: Wilson disease (WD) is a genetic disease with systemic accumulation of copper that leads to symptoms from the liver and brain. However, the underlying defects in copper transport kinetics are only partly understood. We sought to qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9355bca01f94243fd149bee727c2c6c
https://doi.org/10.1002/hep.32238

Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis

Autor: Alan F. Hofmann, Mary Erickson, Kristoffer Kjærgaard, Susanne Keiding, David Shapiro, Michael Sørensen, Anna C. Schacht, Ole Lajord Munk, Jacob Horsager, Kim Frisch

Publikováno v: Kjærgaard, K, Frisch, K, Sørensen, M, Munk, O L, Hofmann, A F, Horsager, J, Schacht, A C, Erickson, M, Shapiro, D A & Keiding, S 2021, ' Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis ', Journal of Hepatology, vol. 74, no. 1, pp. 58-65 . https://doi.org/10.1016/j.jhep.2020.07.028

Background & Aims: Obeticholic acid (OCA) is an agonist of the nuclear bile acid receptor farnesoid X receptor, which regulates hepatic bile acid metabolism. We tested whether OCA treatment would influence hepatic transport of conjugated bile acids i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8852637514a0cfe3f5190f789668a8c
https://doi.org/10.1016/j.jhep.2020.07.028

Reply to: 'Obeticholic acid and hepatic bile acids: Excellent study faulty conclusion'

Autor: Kim Frisch, Susanne Keiding, Alan F. Hofmann

Publikováno v: Keiding, S, Frisch, K & Hofmann, A F 2021, ' Reply to: "Obeticholic acid and hepatic bile acids: Excellent study faulty conclusion" ', Journal of Hepatology, vol. 74, no. 5, pp. 1268-1269 . https://doi.org/10.1016/j.jhep.2021.02.014

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c19c4e14319b58870ac846e22d2caf
https://pubmed.ncbi.nlm.nih.gov/33508377