Výsledky vyhledávání - "Susanne, Hofmann"

Akademický článek

Gender and natural resource extraction in Latin America: Feminist engagements with geopolitical positionality

Autor: Susanne Hofmann, Melisa Cabrapan Duarte

Publikováno v: European Review of Latin American and Caribbean Studies, Iss 111, Pp 39-63 (2021)

This article resituates the debate on approaches to gender in contexts of natural r This article resituates the debate on approaches to gender in contexts of natural resource extraction in Latin America and, subsequently, outlines an intersectional,

Externí odkaz: https://doaj.org/article/2fd8010799814b48a157a8b8aa836a47

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Akademický článek

The N-terminal BRCT domain determines MCPH1 function in brain development and fertility

Autor: Xiaoqian Liu, Nadine Schneble-Löhnert, Martina Kristofova, Xiaobing Qing, Jan Labisch, Susanne Hofmann, Sandra Ehrenberg, Mara Sannai, Tjard Jörß, Alessandro Ori, Maren Godmann, Zhao-Qi Wang

Publikováno v: Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)

Abstract MCPH1 is a causal gene for the neurodevelopmental disorder, human primary microcephaly (MCPH1, OMIM251200). Most pathogenic mutations are located in the N-terminal region of the gene, which encodes a BRCT domain, suggesting an important func

Externí odkaz: https://doaj.org/article/6b3b8820958a43f3aa4ddfbfd3afe4eb

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Akademický článek

Optimized Assessment of qPCR-Based Vector Copy Numbers as a Safety Parameter for GMP-Grade CAR T Cells and Monitoring of Frequency in Patients

Autor: Alexander Kunz, Ulrike Gern, Anita Schmitt, Brigitte Neuber, Lei Wang, Angela Hückelhoven-Krauss, Birgit Michels, Susanne Hofmann, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Maria-Luisa Schubert

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 448-454 (2020)

Chimeric antigen receptor (CAR) T cells are considered genetically modified organisms (GMOs) and constitute gene therapy medicinal products. Thus, CAR T cell manufacturing for clinical application is strictly regulated. Appropriate methods to assess

Externí odkaz: https://doaj.org/article/552ff8d7e29d469aaee520f4a7c9305c

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Akademický článek

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

Autor: Erich Stefan, Richard Obexer, Susanne Hofmann, Khanh Vu Huu, Yichao Huang, Nina Morgner, Hiroaki Suga, Robert Tampé

Publikováno v: eLife, Vol 10 (2021)

ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters involved in a multitude of physiological processes and human diseases. Despite considerable efforts, it remains unclear how ABC transporters harness

Externí odkaz: https://doaj.org/article/c60fc880ff0141849e077e85aa6c65b3

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Akademický článek

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

Autor: Erich Stefan, Susanne Hofmann, Robert Tampé

Publikováno v: eLife, Vol 9 (2020)

ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters, responsible for many physiological processes and human maladies. However, the mechanism how chemical energy of ATP facilitates translocation of chem

Externí odkaz: https://doaj.org/article/dcc4197996474d40af0cdc34e0880413

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Akademický článek

Vida fragmentada: vivir como académica precaria entre dos continentes

Autor: Susanne Hofmann

Publikováno v: Revista de Dialectología y Tradiciones Populares, Vol 73, Iss 1, Pp 25-32 (2018)

La concatenación de breves fragmentos autobiográficos proporciona una imagen vívida de la experiencia de la vida académica precaria contemporánea que transcurre entre continentes. Si bien la trayectoria sin pausa de la autora le permite aprender

Externí odkaz: https://doaj.org/article/611fa583079a4be0ade6b9cb74df9112

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