Výsledky vyhledávání - "Susanne, Geistlich"

Akademický článek

In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [177Lu]Lu-PP-F11N in humans: the lumed phase 0b study

Autor: Christof Rottenburger, Michael Hentschel, Markus Fürstner, Lisa McDougall, Danijela Kottoros, Felix Kaul, Rosalba Mansi, Melpomeni Fani, A. Hans Vija, Roger Schibli, Susanne Geistlich, Martin Behe, Emanuel R. Christ, Damian Wild

Publikováno v: EJNMMI Research, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Background A new generation of radiolabeled minigastrin analogs delivers low radiation doses to kidneys and are considered relatively stable due to less enzymatic degradation. Nevertheless, relatively low tumor radiation doses in patients in

Externí odkaz: https://doaj.org/article/b2acaa6880e14783bd5cb5fd43fcbc99

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Akademický článek

Targeted Radiotherapeutics from 'Bench-to-Bedside'

Autor: Cristina Müller, Martin Béhé, Susanne Geistlich, Nicholas P. van der Meulen, Roger Schibli

Publikováno v: CHIMIA, Vol 74, Iss 12, Pp 939-945 (2020)

he concept of targeted radionuclide therapy (TRT) is the accurate and efficient delivery of radiation to disseminated cancer lesions while minimizing damage to healthy tissue and organs. Critical aspects for successful development of novel radiopharm

Externí odkaz: https://doaj.org/article/97be37d64a124883b7720a8526c2d4d5

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Akademický článek

Neuroimaging with Radiopharmaceuticals Targeting the Glutamatergic System

Autor: Linjing Mu, Stefanie D. Kramer, Hazem Ahmed, Stefan Gruber, Susanne Geistlich, Roger Schibli, Simon M. Ametamey

Publikováno v: CHIMIA, Vol 74, Iss 12, Pp 960-967 (2020)

Radiopharmacy at ETH has worked on the development of novel PET tracers for neuro-, cardiac- and tumor imaging for many years. In this paper, our efforts on targeting the glutamatergic system of the metabotropic glutamate receptor subtype 5 (mGluR5)

Externí odkaz: https://doaj.org/article/71673d550f23497586a85da8a9df44b4

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Akademický článek

Radiation dosimetry of [18F]-PSS232—a PET radioligand for imaging mGlu5 receptors in humans

Autor: Bert-Ram Sah, Michael Sommerauer, Linjing Mu, Gloria Pla Gonzalez, Susanne Geistlich, Valerie Treyer, Roger Schibli, Alfred Buck, Geoffrey Warnock, Simon M. Ametamey

Publikováno v: EJNMMI Research, Vol 9, Iss 1, Pp 1-6 (2019)

Abstract Purpose (E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-(2-[18F]-fluoroethoxy)propyl) oxime ([18F]-PSS232) is a new PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGlu5), and has shown promising results in rodents and

Externí odkaz: https://doaj.org/article/25e65f188ff04962924eeba6d01738bc

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161Tb-DOTATOC Production Using a Fully Automated Disposable Cassette System: A First Step Toward the Introduction of 161Tb into the Clinic

Autor: Chiara Favaretto, Pascal V. Grundler, Zeynep Talip, Stefan Landolt, Lebogang Sepini, Ulli Köster, Cristina Müller, Roger Schibli, Susanne Geistlich, Nicholas P. van der Meulen

Publikováno v: The Journal of Nuclear Medicine, 64 (7)

161Tb is an interesting radionuclide for application in the treatment of neuroendocrine neoplasms' small metastases and single cancer cells because of its conversion and Auger-electron emission. Tb has coordination chemistry similar to that of Lu; th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962c7a31a1e954b13c7ad11695a535ff
https://hdl.handle.net/20.500.11850/622221

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Akademický článek

A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with 68Ga, 44Sc, 177Lu and 161Tb

Autor: Zeynep Talip, Chiara Favaretto, Susanne Geistlich, Nicholas P. van der Meulen

Publikováno v: Molecules, Vol 25, Iss 4, p 966 (2020)

The production of novel radionuclides is the first step towards the development of new effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and clinical phases. In this review, novel radiometal production for medic

Externí odkaz: https://doaj.org/article/5120b62d5b2a4861bc6bac85f7af006c

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Targeted Radiotherapeutics from 'Bench-to-Bedside'

Autor: Nicholas P. van der Meulen, Martin Béhé, Susanne Geistlich, Cristina Müller, Roger Schibli

Publikováno v: CHIMIA, Vol 74, Iss 12, Pp 939-945 (2020)
Chimia, 74 (12)

The concept of targeted radionuclide therapy (TRT) is the accurate and efficient delivery of radiation to disseminated cancer lesions while minimizing damage to healthy tissue and organs. Critical aspects for successful development of novel radiophar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7620ff91b70b10efc18e93be04a260
https://www.ingentaconnect.com/contentone/scs/chimia/2020/00000074/00000012/art00004

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Standards for clinical translation

Radiopharmaceuticals are considered Medicinal Products, thereby they must be prepared and applied within the regulated area of pharmaceuticals. This includes radionuclides, which have seen extraordinary advancements in research and development over t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f96759344bd6e15f10c0da8cf03445a

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