Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Susannah J. Ford"'
Autor:
Kurt Gordon Pike, David R. Perkins, Jonathan M. Eden, Janet D. Culshaw, Barry R. Hayter, Susannah J. Ford
Publikováno v:
Synlett. 23:1816-1820
An efficient method for the substitution of 3-fluoro-2-nitropyridine with a range of nitrogen-containing heterocycles and aliphatic amines is described. The reaction proceeds in a regioselective manner at moderate temperature and in reasonable yield.
Autor:
Neil Rankine, Linda J. Wood, Galith Karoutchi, Michelle Coulson, Keith Oldham, Emma V. Jones, Paul A. Bethel, Stephan Krapp, Susannah J. Ford, Stefan Gerhardt, David Ryan, Matthew Grist, Peter W. Kenny, Hannes Simader, Andrew David Morley, Stuart L. Wells, Gordon A. Hamlin, Stefan Steinbacher, Jack E. Dawson, Nabil Asaad, Martin Augustin, Michael James
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4280-4283
A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.
Autor:
David R. Perkins, Janet D. Culshaw, Susannah J. Ford, Jonathan M. Eden, Barry R. Hayter, Kurt Gordon Pike
Publikováno v:
ChemInform. 43
The fluorine in title compound (I) can be substituted by aliphatic amines or various nitrogen-containing heterocycles.