Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Susannah Elwyn"'
Autor:
Deepti Abbey, Donna Conlon, Christopher Rainville, Susannah Elwyn, Katherine Quiroz‐Figueroa, Jeffrey Billheimer, David C. Schultz, Nicholas J. Hand, Sara Cherry, Daniel J. Rader
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1369-1379 (2021)
Abstract Hepatocytes store triglycerides (TGs) in the form of lipid droplets (LDs), which are increased in hepatosteatosis. The regulation of hepatic LDs is poorly understood and new therapies to reduce hepatosteatosis are needed. We performed a siRN
Externí odkaz:
https://doaj.org/article/b112e81aa3844aa0a2a202a30036c4e6
Publikováno v:
Hepatology Communications, Vol 4, Iss 9, Pp 1316-1331 (2020)
Establishment of a physiologically relevant human hepatocyte‐like cell system for in vitro translational research has been hampered by the limited availability of cell models that accurately reflect human biology and the pathophysiology of human di
Externí odkaz:
https://doaj.org/article/9c41edd5bcb54c81856caaa2124b409f
Autor:
Sylvia T Nurnberg, Marie A Guerraty, Robert C Wirka, H Shanker Rao, Milos Pjanic, Scott Norton, Felipe Serrano, Ljubica Perisic, Susannah Elwyn, John Pluta, Wei Zhao, Stephanie Testa, YoSon Park, Trieu Nguyen, Yi-An Ko, Ting Wang, Ulf Hedin, Sanjay Sinha, Yoseph Barash, Christopher D Brown, Thomas Quertermous, Daniel J Rader
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008538 (2020)
Genome-wide association studies have identified multiple novel genomic loci associated with vascular diseases. Many of these loci are common non-coding variants that affect the expression of disease-relevant genes within coronary vascular cells. To i
Externí odkaz:
https://doaj.org/article/b7dd34ae270f46b99fac5cb149310b65
Autor:
Vivian G Cheung, Renuka R Nayak, Isabel Xiaorong Wang, Susannah Elwyn, Sarah M Cousins, Michael Morley, Richard S Spielman
Publikováno v:
PLoS Biology, Vol 8, Iss 9 (2010)
Expression levels of human genes vary extensively among individuals. This variation facilitates analyses of expression levels as quantitative phenotypes in genetic studies where the entire genome can be scanned for regulators without prior knowledge
Externí odkaz:
https://doaj.org/article/135c66c9ef5b43789c61e7e865406373
Autor:
Daniel J. Rader, Donna M. Conlon, David C. Schultz, Sara Cherry, Nicholas J. Hand, Christopher Rainville, Deepti Abbey, Susannah Elwyn, Katherine Quiroz-Figueroa, Jeffrey T. Billheimer
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 4, Pp 1369-1379 (2021)
Clinical and Translational Science, Vol 14, Iss 4, Pp 1369-1379 (2021)
Hepatocytes store triglycerides (TGs) in the form of lipid droplets (LDs), which are increased in hepatosteatosis. The regulation of hepatic LDs is poorly understood and new therapies to reduce hepatosteatosis are needed. We performed a siRNA kinase
Publikováno v:
Hepatology Communications, Vol 4, Iss 9, Pp 1316-1331 (2020)
Establishment of a physiologically relevant human hepatocyte‐like cell system for in vitro translational research has been hampered by the limited availability of cell models that accurately reflect human biology and the pathophysiology of human di
Autor:
Sanjay Sinha, Felipe Serrano, Marie A Guerraty, Thomas Quertermous, Yi-An Ko, Milos Pjanic, Wei Zhao, Scott Norton, Yoseph Barash, Daniel J. Rader, Ulf Hedin, John Pluta, Robert C. Wirka, Christopher D. Brown, Trieu Nguyen, Sylvia T. Nurnberg, Ljubica Perisic, Stephanie Testa, Ting Wang, Susannah Elwyn, H. Shanker Rao, YoSon Park
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 1, p e1008538 (2020)
PLoS Genetics, Vol 16, Iss 1, p e1008538 (2020)
Genome-wide association studies have identified multiple novel genomic loci associated with vascular diseases. Many of these loci are common non-coding variants that affect the expression of disease-relevant genes within coronary vascular cells. To i
Autor:
Stephen B. Montgomery, Ting Wang, Michael J. Gloudemans, Susannah Elwyn, Sylvia T. Nurnberg, Trieu Nguyen, Daniel J. Rader, Clint L. Miller, Boxiang Liu, Victor G. Castano, Erik Ingelsson, Abhiram Rao, Milos Pjanic, Thomas Quertermous
Coronary artery disease (CAD) is the leading cause of death globally. Genome-wide association studies (GWAS) have identified more than 95 independent loci that influence CAD risk, most of which reside in non-coding regions of the genome. To interpret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d772ed7e88dbb5b5db1e662be3ddb331
https://doi.org/10.1101/309559
https://doi.org/10.1101/309559
Autor:
Susannah Elwyn, Sylvia T. Nurnberg, Joebert Rosal, Daniel J. Rader, Stephanie Testa, Wei Zhao
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
Genome-wide association studies (GWAS) have identified rs2107595 as association SNP for both stroke and cardiovascular disease. This polymorphism is located proximal to the HDAC9 gene, with TWIST1 106kb downstream as the next closest gene in the reco
Publikováno v:
Genetics. 173:225-233
A major unresolved challenge of evolutionary biology is to determine the nature of the allelic variants of “speciation genes”: those alleles whose interaction produces inviable or infertile interspecific hybrids but does not reduce fitness in pur