Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Susannah Davies"'
New designer drugs, access to databases, and changing availability of samples for analysis have changed the face of modern forensic toxicology in recent years. Forensic Toxicology: Drug Use and Misuse brings together the latest information direct fro
Autor:
Susannah Davies, Fiona Measham, David M. Wood, Michelle Wood, Simon Hudson, John Ramsey, John R. H. Archer, Malgorzata Puchnarewicz, Andrew T. Kicman, Paul I. Dargan, Atholl Johnston
Publikováno v:
Journal of Substance Use. 19:103-107
Background: The epidemiology on recreational drug use is based on self-reported user surveys. The scope of this is limited as users are often not aware of exactly what drug(s) they are using. Waste water (sewage plant) analysis has been used to ident
Autor:
Adam R. Winstock, Luke Mitcheson, John Marsden, John Ramsey, Malgorzata Puchnarewicz, Susannah Davies
Publikováno v:
Addiction. 106:1991-1996
Aims To assess the patterns of use, subjective effect profile and dependence liability of mephedrone, supported by corroborative urine toxicology. Design Cross-sectional structured telephone interview. Setting UK-based drug users associated with the
Autor:
David M. Wood, Susannah Davies, David W. Holt, John Ramsey, Jenny Button, S L Greene, Paul I. Dargan
Publikováno v:
Clinical Toxicology. 48:924-927
Previous reports of acute toxicity/harm associated with mephedrone use have been based on self-reported mephedrone use; toxicological screening has not been undertaken in these cases to determine whether mephedrone has been used.To report the first c
Autor:
Terry Lee, Jenny Button, Malgorzata Puchnarewicz, Susannah Davies, Hanna Ovaska, Paul I. Dargan, John Ramsey, David M. Wood, Roland P. Archer, David W. Holt
Publikováno v:
Journal of Medical Toxicology. 6:327-330
Cathinone is a pharmacologically active alkaloid that can be extracted from the leaves of the khat plant (Catha edulis). There are synthetic derivatives of cathinone entering the recreational drug market, including mephedrone (4-methylmethcathinone,
Autor:
David W. Holt, Satnam Lidder, Loua Shaikh, Jenny Button, John Ramsey, David M. Wood, Susannah Davies, Jemma J. Looker, Paul I. Dargan, Malgorzata Puchnarewicz
Publikováno v:
Journal of Medical Toxicology. 5:226-229
Many countries have specific legislation, such as the Controlled Substances Act (1970) in the United States and the Misuse of Drugs Act (1971) in the United Kingdom to control recreational drugs. There is a growing market and supply of "novel" recrea
Autor:
Beverley Smith, Alessandra Gaiba, Jon Graham Anthony Steadman, Penelope C. Staton, Antoinette Naylor, David Matthew Wilson, Robert P. Davis, Susannah Davies, Tania O. Stean, Alastair D. Reith, Mark James Bamford, Christopher A. Parr, David Kenneth Dean, Frank D. King, Andrew K. Takle, Elaine A. Irving, Alison M. Ray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4373-4376
Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. One such compound, SB-699393 (17), was examined in vivo to challenge the hypothe
Autor:
Kieran O'Donovan, Anthony R. Newcombe, Chrissie Cresswell, Richard Francis, Susannah Davies, Felicity Pearce
Publikováno v:
Process Biochemistry. 41:842-847
Here, we evaluate an automated, direct binding surface plasmon resonance (Biacore® C) biosensor assay for the determination of total IgG in hyper-immunised ovine serum for use within the biopharmaceutical industry for production of polyclonal Fab fr
Autor:
James T. Townsend, Alessandra Gaiba, David Kendall Jung, Christopher A. Parr, John D. Harling, David Matthew Wilson, Mark James Bamford, Stephen L. Garland, Susannah Davies, Nicholas Bailey, Jason Witherington, Michael J. Alberti, Andrew K. Takle, David Kenneth Dean, Jon Graham Anthony Steadman, Terence A. Panchal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3402-3406
A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1.
Autor:
Keith Watson, Susannah Davies, Richard Francis, Anthony R. Newcombe, Chrissie Cresswell, Kieran O'Donovan, Guy Harris
Publikováno v:
Journal of Chromatography B. 814:209-215
This report describes the applicability of a synthetic chromatography adsorbent for large-scale purification of polyclonal immunoglobulin G from hyper immunised ovine serum. Under optimised conditions, MAbsorbent A2P was shown to bind approximately 2