Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Susanna Zierler"'
Autor:
Noushafarin Khajavi, Andreas Beck, Klea Riçku, Philipp Beyerle, Katharina Jacob, Sabrina F. Syamsul, Anouar Belkacemi, Peter S. Reinach, Pascale C.F. Schreier, Houssein Salah, Tanja Popp, Aaron Novikoff, Andreas Breit, Vladimir Chubanov, Timo D. Müller, Susanna Zierler, Thomas Gudermann
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Most overweight individuals do not develop diabetes due to compensatory islet responses to restore glucose homeostasis. Therefore, regulatory pathways that promote β cell compensation are potential targets for treatment of diabetes. The transient re
Externí odkaz:
https://doaj.org/article/3e995b7dace7473fa3fc520fc567dc3c
Autor:
Barbara Spix, Elisabeth S. Butz, Cheng-Chang Chen, Anna Scotto Rosato, Rachel Tang, Aicha Jeridi, Veronika Kudrina, Eva Plesch, Philipp Wartenberg, Elisabeth Arlt, Daria Briukhovetska, Meshal Ansari, Gizem Günes Günsel, Thomas M. Conlon, Amanda Wyatt, Sandra Wetzel, Daniel Teupser, Lesca M. Holdt, Fabien Ectors, Ingrid Boekhoff, Ulrich Boehm, Jaime García-Añoveros, Paul Saftig, Martin Giera, Sebastian Kobold, Herbert B. Schiller, Susanna Zierler, Thomas Gudermann, Christian Wahl-Schott, Franz Bracher, Ali Önder Yildirim, Martin Biel, Christian Grimm
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the l
Externí odkaz:
https://doaj.org/article/7d029bd581f74fcaa96bcacc1faef5b8
Autor:
Monika I. Hollenhorst, Rajender Nandigama, Saskia B. Evers, Igor Gamayun, Noran Abdel Wadood, Alaa Salah, Mario Pieper, Amanda Wyatt, Alexey Stukalov, Anna Gebhardt, Wiebke Nadolni, Wera Burow, Christian Herr, Christoph Beisswenger, Soumya Kusumakshi, Fabien Ectors, Tatjana I. Kichko, Lisa Hübner, Peter Reeh, Antje Munder, Sandra-Maria Wienhold, Martin Witzenrath, Robert Bals, Veit Flockerzi, Thomas Gudermann, Markus Bischoff, Peter Lipp, Susanna Zierler, Vladimir Chubanov, Andreas Pichlmair, Peter König, Ulrich Boehm, Gabriela Krasteva-Christ
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Constant exposure of the airways to inhaled pathogens requires efficient early immune responses protecting against infections. How bacteria on the epithelial surface are detected and first-line protective mechanisms are initiated are not well underst
Externí odkaz:
https://doaj.org/article/b6c462ddd8474b69bfe5c8500b0b830e
Autor:
Astrid Kollewe, Vladimir Chubanov, Fong Tsuen Tseung, Leonor Correia, Eva Schmidt, Anna Rössig, Susanna Zierler, Alexander Haupt, Catrin Swantje Müller, Wolfgang Bildl, Uwe Schulte, Annette Nicke, Bernd Fakler, Thomas Gudermann
Publikováno v:
eLife, Vol 10 (2021)
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 plays a fundamental role in the cellular uptake of divalent cations such a
Externí odkaz:
https://doaj.org/article/069728908b0a4dfe9645de8e3e8aa566
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/859a309be79849488b8e83c2c9870dc1
Publikováno v:
Cells, Vol 11, Iss 9, p 1465 (2022)
Two-pore channels (TPCs) are ligand-gated cation-selective ion channels that are preserved in plant and animal cells. In the latter, TPCs are located in membranes of acidic organelles, such as endosomes, lysosomes, and endolysosomes. Here, we focus o
Externí odkaz:
https://doaj.org/article/427d966c0021464a8c568bd4c22aa8ca
Autor:
Wiebke Nadolni, Roland Immler, Kilian Hoelting, Marco Fraticelli, Myriam Ripphahn, Simone Rothmiller, Masayuki Matsushita, Ingrid Boekhoff, Thomas Gudermann, Markus Sperandio, Susanna Zierler
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
During inflammation, neutrophils are one of the first responding cells of innate immunity, contributing to a fast clearance of infection and return to homeostasis. However, excessive neutrophil infiltration accelerates unsolicited disproportionate in
Externí odkaz:
https://doaj.org/article/7c8ee04e5a11479d9b310f0f5b376134
Autor:
Susanne Gerndt, Cheng-Chang Chen, Yu-Kai Chao, Yu Yuan, Sandra Burgstaller, Anna Scotto Rosato, Einar Krogsaeter, Nicole Urban, Katharina Jacob, Ong Nam Phuong Nguyen, Meghan T Miller, Marco Keller, Angelika M Vollmar, Thomas Gudermann, Susanna Zierler, Johann Schredelseker, Michael Schaefer, Martin Biel, Roland Malli, Christian Wahl-Schott, Franz Bracher, Sandip Patel, Christian Grimm
Publikováno v:
eLife, Vol 9 (2020)
Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (Calcraft et al., 2009; Guo et al., 2017; Jha et al., 2014; Ruas et
Externí odkaz:
https://doaj.org/article/64c41b16eef7442a8eaf94088d92df5d
Autor:
Andrea Romagnani, Valentina Vettore, Tanja Rezzonico-Jost, Sarah Hampe, Elsa Rottoli, Wiebke Nadolni, Michela Perotti, Melanie A. Meier, Constanze Hermanns, Sheila Geiger, Gunther Wennemuth, Camilla Recordati, Masayuki Matsushita, Susanne Muehlich, Michele Proietti, Vladimir Chubanov, Thomas Gudermann, Fabio Grassi, Susanna Zierler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by mod
Externí odkaz:
https://doaj.org/article/81c11da70637480eb4d002bc8644c76b
Autor:
Silvia Ferioli, Susanna Zierler, Joanna Zaißerer, Johann Schredelseker, Thomas Gudermann, Vladimir Chubanov
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-19 (2017)
Abstract TRPM6 and its homologue TRPM7 are α-kinase-coupled divalent cation-selective channels activated upon reduction of cytosolic levels of Mg2+ and Mg·ATP. TRPM6 is vital for organismal Mg2+ balance. However, mechanistically the cellular role a
Externí odkaz:
https://doaj.org/article/ed61a16c849844f1ac78a313b8afcf6c