Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Susanna Zamolo"'
Autor:
Haneen Daralnakhla, Osama Saher, Susanna Zamolo, Safa Bazaz, Jeremy P. Bost, Marc Heitz, Karin E. Lundin, Samir EL Andaloussi, Tamis Darbre, Jean-Louis Reymond, Rula Zain, C. I. Edvard Smith
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 116 (2021)
Non-viral transfection reagents are continuously being developed in attempt to replace viral vectors. Among those non-viral vectors, dendrimers have gained increasing interest due to their unique molecular structure and multivalency. However, more im
Externí odkaz:
https://doaj.org/article/e84a65a6d42842468f0d790bd355f8c4
Publikováno v:
Molecules, Vol 24, Iss 15, p 2814 (2019)
A series of 2-nm gold nanoparticles passivated with different thiols all featuring at least one triazacyclonanone-Zn(II) complex and different flanking units (a second Zn(II) complex, a triethyleneoxymethyl derivative or a guanidinium of arginine of
Externí odkaz:
https://doaj.org/article/29fa4b4cb60548ac94e5e33cec43e13d
Publikováno v:
Heitz, Marc; Zamolo, Susanna; Javor, Sacha; Reymond, Jean-Louis (2020). Fluorescent Peptide Dendrimers for siRNA Transfection: Tracking pH Responsive Aggregation, siRNA Binding, and Cell Penetration. Bioconjugate chemistry, 31(6), pp. 1671-1684. American Chemical Society 10.1021/acs.bioconjchem.0c00231
Transfecting nucleic acids into various cells is a key procedure in biological research also envisioned for therapeutic applications. In our effort to obtain simple reagents that would be readily accessible from commercial building blocks, we recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31231bc6b02e10f6dbc06ed7995db99
https://doi.org/10.1021/acs.bioconjchem.0c00231
https://doi.org/10.1021/acs.bioconjchem.0c00231
Autor:
Paolo Scrimin, Riccardo Rigo, Fabrizio Mancin, Claudia Sissi, Marco De Vivo, Adam Pecina, Susanna Zamolo, Tamis Darbre, Joanna Czescik, Laura Riccardi
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
Similarly to enzymes, functionalized gold nanoparticles efficiently catalyze chemical reactions, hence the term nanozymes. Herein, we present our results showing how surface‐passivated gold nanoparticles behave as synthetic nanonucleases, able to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969ac372c22b736ef8cc0ce46704243e
Publikováno v:
Zamolo, Susanna J.; Darbre, Tamis; Reymond, Jean-Louis (2020). Transfecting tissue models with CRISPR/Cas9 plasmid DNA using peptide dendrimers. Chemical communications, 56(80), pp. 11981-11984. Royal Society of Chemistry 10.1039/D0CC04750C
Chemical Communications
Chemical Communications
There is currently a lack of efficient reagents to transfect cells with large plasmid DNA, which would be enabling tools for gene editing using CRISPR/Cas9 technology. Herein, we report the discovery of peptide dendrimer Z22 as a non-viral vector for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc35326ccf62b1cab610804e75b6cbf4
https://boris.unibe.ch/148878/1/d0cc04750c.pdf
https://boris.unibe.ch/148878/1/d0cc04750c.pdf
Autor:
Oscar P. B. Wiklander, Kariem Ezzat, Jean-Louis Reymond, Florian Hollfelder, Dhanu Gupta, C. I. Edvard Smith, Rula Zain, Osama Saher, Eman M. Zaghloul, Cristina S. J. Rocha, Marc Heitz, Karin E. Lundin, Samir El Andaloussi, Susanna Zamolo, Tamis Darbre
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics
Despite the advances in gene therapy and in oligonucleotide (ON) chemistry, efficient cellular delivery remains an obstacle. Most current transfection reagents suffer from low efficacy or high cytotoxicity. In this report, we describe the synergism b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec1fed14190a4ba0f137b1c39d1b8c4