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pro vyhledávání: '"Susanna T. E. Cooper"'
Autor:
Susanna T. E. Cooper, Joseph D. Westaby, Zoe H. R. Haines, Giles O. Malone, Mary N. Sheppard, Daniel N. Meijles
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7709 (2022)
Hypertension is a major public health concern and poses a significant risk for sudden cardiac death (SCD). However, the characterisation of human tissues tends to be macroscopic, with little appreciation for the quantification of the pathological rem
Externí odkaz:
https://doaj.org/article/baf85bcc460843ed8511bc213c5a7ccf
Autor:
Elijah R. Behr, Tarek F.T. Antonios, Joseph Westaby, Chris Miles, I. Chis Ster, Daniel N. Meijles, Susanna T. E. Cooper, Mary N. Sheppard
Publikováno v:
Journal of Human Hypertension. 36:246-253
Hypertensive heart disease refers to changes in the myocardium that result from hypertension. The relationship between hypertensive heart disease and sudden cardiac death is well established, but there are few pathological studies. We examined the cl
Autor:
Daniel N. Meijles, Susanna T. E. Cooper, Peter E. Glennon, John Sembrat, Spencer Shaw, Leanne E. Felkin, Angela Clerk, Mauricio Rojas, Peter H. Sugden, Thomais Markou, Sam J. Leonard, M. N. Sheppard, K. Vanezis, Michelle A. Hardyman, Owen J. L. Rackham, Joshua J Cull, Paul J.R. Barton, Charles F. McTiernan, S A Cook, Sonia Chothani, Stephen J. Fuller, Hajed O. Alharbi
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if BRAF is relevant for human hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121752225409a1c8d37392fa7f2ed3a0
https://doi.org/10.1101/2021.08.14.455637
https://doi.org/10.1101/2021.08.14.455637
Autor:
Susanna T. E. Cooper, Angela Clerk, Stephen J. Fuller, Joshua J Cull, Hajed O. Alharbi, Peter H. Sugden, Daniel N. Meijles
Publikováno v:
Biochemical Journal
Insulin and insulin-like growth factor stimulate protein synthesis and cardioprotection in the heart, acting through their receptors (INSRs, IGF1Rs) and signalling via protein kinase B (PKB, also known as Akt). Protein synthesis is increased in heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5aeefe6e4ed0e769ba7ee2049de61e
https://openaccess.sgul.ac.uk/id/eprint/113355/1/bcj-2021-0144.pdf
https://openaccess.sgul.ac.uk/id/eprint/113355/1/bcj-2021-0144.pdf
Publikováno v:
Basic science.
Publikováno v:
The American Journal of Cardiology. 124:808-811
Nonpenetrating blunt force trauma to the front of the chest can lead to commotio cordis, a cardiac rhythm disturbance, which can result in cardiac arrest and death. The condition is particularly noted during sport. No series of such cases has been pu
Autor:
Daniel N. Meijles, Angela Clerk, Feroz Ahmad, Susanna T. E. Cooper, Peter H. Sugden, Zoe Haines, Stephen J. Fuller, Hajed O. Alharbi, Joshua J Cull, Viridiana Alcantara Alonso
Publikováno v:
Circulation. 142
Introduction: Epidermal growth factor (EGF) receptors (EGFRs: ERBB1-4) are activated by a family of ligands (e.g. EGF, Hb-EGF, EREG, TGFa), signaling through ERK1/2 and Akt to promote cell division and cancer. Antibody-based inhibition of ERBB2 in br
Publikováno v:
Clinical anatomy (New York, N.Y.)References. 33(3)
Congenital heart disease is a rare but important finding in adults that experience sudden death. Examination of the congenitally malformed heart has historically been considered esoteric, and best left to those with expertise. The Cardiac Risk in the