Differential Effects of Angelicin Analogues on NF-κB Activity and IL-8 Gene Expression in Cystic Fibrosis IB3-1 Cells

Autor: Ilaria Lampronti, Maria Giulia Manzione, Gianni Sacchetti, Davide Ferrari, Susanna Spisani, Valentino Bezzerri, Alessia Finotti, Monica Borgatti, Maria Cristina Dechecchi, Giorgia Miolo, Giovanni Marzaro, Giulio Cabrini, Roberto Gambari, Adriana Chilin

Publikováno v: Mediators of Inflammation, Vol 2017 (2017)

The angelicin analogue 4,6,4′-trimethylangelicin (TMA) was recently reported as a strong inhibitor of nuclear factor-κB (NF-κB) activity and of the expression of the interleukin-8 (IL-8) gene in bronchial epithelial cells in which the inflammator

Externí odkaz: https://doaj.org/article/cbeed5c6a5934887988e7f08e22463ea

Effects of Synthetic Peptides on the Inflammatory Response and their Therapeutic Potential

Autor: Rita, Selvatici, Selvatici, Rita, Anna, Siniscalchi, Siniscalchi, Anna, Susanna, Spisani, Spisani, Susanna

Publikováno v: Mini-Reviews in Medicinal Chemistry. 13:553-564

Recently, interest in small peptide molecules as potential drug candidates has revived. In this review, two series of synthetic peptides and their selective effects on the inflammatory response have been described, focusing on the intracellular pathw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56034681a22a982ebbfb9a61c67221f
https://doi.org/10.2174/1389557511313040008

Conformational Aspects of Human Formylpeptide Receptor Antagonists

Autor: Angelo Scatturin, Vertuani Gianni, Rita Pecoraro, Alessandro Dalpiaz, Marisa Boggian, Maria Ferretti, Susanna Spisani

Publikováno v: Arzneimittelforschung. 49:873-877

The conformation of several Phe-D-Leu-Phe-D-Leu-Phe analogues was analyzed using infrared absorption and circular dichroism. Their effect on human neutrophils was verified by receptor binding and chemotaxis assays. The results demonstrate that the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f954584cba3321037cc71e264386ba
https://doi.org/10.1055/s-0031-1300519

Structure-activity relationships of cyclic and linear peptide T analogues

Autor: V. Scaranari, Eva Reali, Mauro Marastoni, Roberto Tomatis, S. Salvadori, G. Balboni, Serena Traniello, Susanna Spisani

Publikováno v: Scopus-Elsevier

Using the potent cyclic peptide T analog-Thr-Thr-Asn-Tyr-Thr-Asp- as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Stru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5092021566d258b04d5af330c6a0167c
https://doi.org/10.1111/j.1399-3011.1993.tb00464.x

Chemotactic tripeptides incorporating at position 2 α-aminoacid residues with unsaturated side chains

Autor: Susanna Spisani, Gino Lucente, Cesare Giordano, Domenica Torino, Anna Sansone, Mario Paglialunga Paradisi

Publikováno v: Amino acids (Wien, Print) 35 (2008): 329–338. doi:10.1007/s00726-007-0621-1
info:cnr-pdr/source/autori:Gino Lucente; Mario Paglialunga Paradisi; Cesare Giordano; Anna Sansone; Domenica Torino; Susanna Spisani/titolo:Chemotactic tripeptides incorporating at position 2 alpha-aminoacid residues with unsaturated side chains/doi:10.1007%2Fs00726-007-0621-1/rivista:Amino acids (Wien, Print)/anno:2008/pagina_da:329/pagina_a:338/intervallo_pagine:329–338/volume:35

New N-For-Met-Leu-Phe-OMe (fMLF-OMe) analogues incorporating three different gamma-delta-didehydro-alpha-aminoacid residues (namely: Alg = (S)-Allylglycine; Dag = Diallylglycine; Cpg = 1-Aminocyclopent-3-ene-1-carboxylic acid) replacing the native (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51aac67ddbbca4e21d1660fd887b088a
https://doi.org/10.1007/s00726-007-0621-1