Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age

Autor: Antonino Zito, Matthew N. Davies, Pei-Chien Tsai, Susanna Roberts, Rosa Andres-Ejarque, Stefano Nardone, Jordana T. Bell, Chloe C. Y. Wong, Kerrin S. Small

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Skewing of X chromosome inactivation (XCI) occurs when the silencing of one parental X chromosome is non-random. Here, Zito et al. report XCI patterns in lymphoblastoid cell lines, blood, subcutaneous adipose tissue samples and skin samples of monozy

Externí odkaz: https://doaj.org/article/a930e629700d41afa50c28ffc5023117

DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample

Autor: Joe Burrage, Chloe C. Y. Wong, Georgina Mansell, Helen L. Fisher, Radhika Kandaswamy, Eilis Hannon, Susanna Roberts, Karen Sugden, Ehsan Pishva, Jonathan Mill, Benjamin Williams, Andrea Danese, Louise Arseneault, Aisha Dahir, James R Staley

Publikováno v: Epigenetics
article-version (VoR) Version of Record

Accumulating evidence suggests that individuals exposed to victimization at key developmental stages may have different epigenetic fingerprints compared to those exposed to no/minimal stressful events, however results are inconclusive. This study aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e4737ab819b8b2b5c7baa98204cf86
http://europepmc.org/articles/PMC8813077

Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: A meta-analysis

Autor: Sylvia Helbig-Lang, Jiaxi Lin, Gerhard Andersson, Thalia C. Eley, Katharina Domschke, Susanna Roberts, Paul Pauli, Jennifer L. Hudson, Jan Bergström, Jan Richter, Kathryn J. Lester, Alexander L. Gerlach, Alfons O. Hamm, Ulrike Lueken, Winfried Rief, Christiane Thiel, Volker Arolt, Andreas Reif, Tina B. Lonsdorf, Heike Weber, Koen Schruers, Miriam A. Schiele, Hans-Ulrich Wittchen, Evelyn Andersson, T. Lang, Christian Rück, Nils Lindefors, Per Carlbring, Georg W. Alpers, Gabriel Esquivel, Tomas Furmark

Publikováno v: European Neuropsychopharmacology, 44, 105-120. Elsevier
Schiele, M A, Reif, A, Lin, J, Alpers, G W, Andersson, E, Andersson, G, Arolt, V, Bergström, J, Carlbring, P, Eley, T C, Esquivel, G, Furmark, T, Gerlach, A L, Hamm, A, Helbig-Lang, S, Hudson, J L, Lang, T, Lester, K J, Lindefors, N, Lonsdorf, T B, Pauli, P, Richter, J, Rief, W, Roberts, S, Rück, C, Schruers, K R J, Thiel, C, Wittchen, H U, Domschke, K, Weber, H & Lueken, U 2021, ' Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders : A meta-analysis ', European Neuropsychopharmacology, vol. 44, pp. 105-120 . https://doi.org/10.1016/j.euroneuro.2021.01.004

There is a recurring debate on the role of the serotonin transporter gene linked polymorphic region (5-HTTLPR) in the moderation of response to cognitive behavioral therapy (CBT) in anxiety disorders. Results, however, are still inconclusive. We here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355ccf57f07705001f3910e50967192e
https://cris.maastrichtuniversity.nl/en/publications/fedd3c57-3ac1-4796-9697-84222d108383

DNA methylation of FKBP5 and response to exposure‐based psychological therapy

Autor: Jürgen Margraf, Jonathan R. I. Coleman, Tobias Teismann, Peter Jöhren, Thalia C. Eley, Agnieszka Kepa, Susanna Roberts, Silvia Scheider, Chloe C. Y. Wong, Robert Keers, Kathryn J. Lester, André Wannemüller, Gerome Breen

Publikováno v: American Journal of Medical Genetics
Roberts, S, Keers, R, Breen, G, Coleman, J R I, Jöhren, P, Kepa, A, Lester, K J, Margraf, J, Scheider, S, Teismann, T, Wannemüller, A, Eley, T C & Wong, C C Y 2018, ' DNA methylation of FKBP5 and response to exposure-based psychological therapy ', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics . https://doi.org/10.1002/ajmg.b.32650

Differential DNA methylation of the hypothalamic-pituitary-adrenal axis related gene FKBP5 has recently been shown to be associated with varying response to environmental influences and may play a role in how well people respond to psychological trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab82d96132857d7b25237b123133e12
https://doi.org/10.1002/ajmg.b.32650

A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders

Autor: Peter J. Cooper, Mikael Thastum, Kirstin L. Purves, Thomas Fydrich, Jürgen Margraf, Einar Heiervang, Ronald M. Rapee, Sang-hyuck Lee, Christopher Rayner, André Wannemüller, Winfried Rief, Susanna Roberts, Christiane A. Pané-Farré, Alexander L. Gerlach, Charles Curtis, Katharina Domschke, Wendy K. Silverman, Martin Schalling, Tobias Teismann, Peter Jöhren, Kimberley Goldsmith, Thomas Lang, Cathy Creswell, Alfons O. Hamm, Erik Hedman, Evelyn Andersson, Georg W. Alpers, Susan M. Bögels, Christiane Wolf, John Hodsoll, Volker Arolt, Andreas Ströhle, Christian Rück, Gerome Breen, Jonathan R. I. Coleman, Andreas Reif, Heike Weber, Thalia C. Eley, Jennifer L. Hudson, Lydia Fehm, Jürgen Deckert, Anja Grocholewski, Robert Keers, Silvia Schneider, Julia Boberg, Nils Lindefors, Kathryn J. Lester, Tilo Kircher, Catharina Lavebratt, Samir El Alaoui, Maaike H. Nauta, Hans-Ulrich Wittchen, Kurt Hahlweg, Paul Pauli

Publikováno v: Translational Psychiatry
Translational Psychiatry, 9:150. Nature Publishing Group
Translational Psychiatry, Vol 9, Iss 1, Pp 1-13 (2019)
Rayner, C D, Coleman, J R I, Purves, K, Hodsoll, J, Goldsmith, K, Curtis, C J, Lee, S H, Alpers, G W, Evelyn, A, Arolt, V, Boberg, J, Bogels, S, Creswell, C, Cooper, P, Deckert, J, Domschke, K, El Alaoui, S, Fehm, L, Growcholewski, A, Hahlweg, K, Hamm, A, Hedman, E, Heiervang, E, Hudson, J, Johren, P, Keers, R, Kircher, T, Lang, T, Lavebratt, C, Lester, K, Lindefors, N, Margraf, J, Nauta, M, Pane-Farre, C, Pauli, P, Reif, A, Rapee, R M, Roberts, S L, Schalling, M, Schneider, S, Silverman, W K, Ströhle, A, Teismann, T, Thastum, M, Wannemüller, A, Weber, H, Wolf, C, Ruck, C, Breen, G D & Eley, T C 2019, ' A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders ', Translational psychiatry, vol. 9, no. 1, 150 . https://doi.org/10.1038/s41398-019-0481-y
Rayner, C, Coleman, J R I, Purves, K L, Hodsoll, J, Goldsmith, K, Alpers, G W, Andersson, E, Arolt, V, Boberg, J, Bögels, S, Creswell, C, Cooper, P, Curtis, C, Deckert, J, Domschke, K, El Alaoui, S, Fehm, L, Fydrich, T, Gerlach, A L, Grocholewski, A, Hahlweg, K, Hamm, A, Hedman, E, Heiervang, E R, Hudson, J L, Jöhren, P, Keers, R, Kircher, T, Lang, T, Lavebratt, C, Lee, S-H, Lester, K J, Lindefors, N, Margraf, J, Nauta, M, Pané-Farré, C A, Pauli, P, Rapee, R M, Reif, A, Rief, W, Roberts, S, Schalling, M, Schneider, S, Silverman, W K, Ströhle, A, Teismann, T, Thastum, M, Wannemüller, A, Weber, H, Wittchen, H-U, Wolf, C, Rück, C, Breen, G & Eley, T C 2019, ' A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders ', Translational Psychiatry, vol. 9, no. 1, 150 . https://doi.org/10.1038/s41398-019-0481-y

Major depressive disorder and the anxiety disorders are highly prevalent, disabling and moderately heritable. Depression and anxiety are also highly comorbid and have a strong genetic correlation (rg ≈ 1). Cognitive behavioural therapy is a leading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424db4d60a4ef8973df2023f6e6be45d
https://dare.uva.nl/personal/pure/en/publications/a-genomewide-association-metaanalysis-of-prognostic-outcomes-following-cognitive-behavioural-therapy-in-individuals-with-anxiety-and-depressive-disorders(bd570d03-8da8-485e-980c-3ddaf27589e9).html