Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Susanna R Keller"'
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207325 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0204100.].
Externí odkaz:
https://doaj.org/article/1614555deeee41759d99ab375bca9748
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204100 (2018)
One of the biggest challenges in analyzing high throughput omics data in biological studies is extracting information that is relevant to specific biological mechanisms of interest while simultaneously restricting the number of false positive finding
Externí odkaz:
https://doaj.org/article/5e9007ee73d946109b5e20d29394f083
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127031 (2015)
Metabolic disorders have been established as major risk factors for ocular complications and poor vision. However, little is known about the inverse possibility that ocular disease may cause metabolic dysfunction. To test this hypothesis, we assessed
Externí odkaz:
https://doaj.org/article/4a0ae8ec13f642c6b8efc18dd7d6e314
Autor:
Jie Li, Krzysztof Minczuk, Qiao Huang, Brandon A. Kemp, Nancy L. Howell, Mahendra D. Chordia, R. Jack Roy, James T. Patrie, Zoraiz Qureshi, Christopher M. Kramer, Frederick H. Epstein, Robert M. Carey, Bijoy K. Kundu, Susanna R. Keller
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 10 (2023)
Background Cardiac metabolic abnormalities are present in heart failure. Few studies have followed metabolic changes accompanying diastolic and systolic heart failure in the same model. We examined metabolic changes during the development of diastoli
Externí odkaz:
https://doaj.org/article/9011a48a5c1e4675bfa38921eb341a41
Autor:
Brandon A. Kemp, Nancy L. Howell, John J. Gildea, Josh D. Hinkle, Jeffrey Shabanowitz, Donald F. Hunt, Mark R. Conaway, Susanna R. Keller, Robert M. Carey
Publikováno v:
Circulation Research. 132:1127-1140
Background: Extracellular renal interstitial guanosine cyclic 3’,5’-monophosphate (cGMP) inhibits renal proximal tubule (RPT) sodium (Na + ) reabsorption via Src (Src family kinase) activation. Through which target extracellular cGMP acts to indu
Autor:
Subramanian Senthivinayagam, Vlad Serbulea, Clint M. Upchurch, Renata Polanowska-Grabowska, Suresh K. Mendu, Srabani Sahu, Prathiba Jayaguru, Kevin W. Aylor, Mahendra D. Chordia, Limor Steinberg, Nathaniel Oberholtzer, Seichii Uchiyama, Noriko Inada, Ulrike M. Lorenz, Thurl E. Harris, Susanna R. Keller, Akshaya K. Meher, Alexandra Kadl, Bimal N. Desai, Bijoy K. Kundu, Norbert Leitinger
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101130- (2021)
Objective: Brown adipose tissue (BAT) is specialized in thermogenesis. The conversion of energy into heat in brown adipocytes proceeds via stimulation of β-adrenergic receptor (βAR)-dependent signaling and activation of mitochondrial uncoupling pro
Externí odkaz:
https://doaj.org/article/3bac5da2881d485a8632564ecf041a48
Autor:
Qianyi Yang, Jameson Hinkle, Jordan N. Reed, Redouane Aherrahrou, Zhiwen Xu, Thurl E. Harris, Erin J. Stephenson, Kiran Musunuru, Susanna R. Keller, Mete Civelek
Publikováno v:
Diabetes
Genome-wide association studies identified single nucleotide polymorphisms on chromosome 7 upstream of KLF14 to be associated with metabolic syndrome traits and increased risk for Type 2 Diabetes (T2D). The associations were more significant in women
Autor:
Susanna R. Keller, David L. Brautigan, John J Gildea, Robert M. Carey, Nancy L. Howell, Brandon A. Kemp
Publikováno v:
Circulation Research. 130:96-111
Background: How signals from activated angiotensin type-2 receptors (AT 2 R) mediate inhibition of sodium ion (Na + ) reabsorption in renal proximal tubule cells is currently unknown. Protein phosphatases including PP2A (protein phosphatase 2A) have
Autor:
Laura J W Keppley, Alexis N Gademsey, Susanna R. Keller, Jason P. Smith, Todd E. Fox, Susan J. Walker, Mark Kester
Publikováno v:
FASEB J
Lipid perturbations contribute to detrimental outcomes in obesity. We previously demonstrated that nervonic acid, a C24:1 ω-9 fatty acid, predominantly acylated to sphingolipids, including ceramides, are selectively reduced in a mouse model of obesi
Publikováno v:
Circulation Research. 126:644-659
Rationale: Previous studies identified a defect in Ang III (angiotensin III [des-aspartyl 1 -angiotensin II])–elicited AT 2 R (Ang type-2 receptor)-mediated natriuresis in renal proximal tubule cells of spontaneously hypertensive rats (SHR). Object