Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Susanna Nikolaus"'
Autor:
Antonella Fazio, Dora Bordoni, Jan W. P. Kuiper, Saskia Weber-Stiehl, Stephanie T. Stengel, Philipp Arnold, David Ellinghaus, Go Ito, Florian Tran, Berith Messner, Anna Henning, Joana P. Bernardes, Robert Häsler, Anne Luzius, Simon Imm, Finn Hinrichsen, Andre Franke, Samuel Huber, Susanna Nikolaus, Konrad Aden, Stefan Schreiber, Felix Sommer, Gioacchino Natoli, Neha Mishra, Philip Rosenstiel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
DNA methyltransferase 3 A (DNMT3A) is involved in DNA methylation, and genetic variants in the DNMT3 locus have been associated with inflammatory bowel disease. Here the authors report that DNMT3A controls intestinal epithelial barrier function and r
Externí odkaz:
https://doaj.org/article/ddcd39941f044c5d889d3ab0cea581ef
Autor:
Neha Mishra, Konrad Aden, Johanna I. Blase, Nathan Baran, Dora Bordoni, Florian Tran, Claudio Conrad, Diana Avalos, Charlot Jaeckel, Michael Scherer, Signe B. Sørensen, Silja H. Overgaard, Berenice Schulte, Susanna Nikolaus, Guillaume Rey, Gilles Gasparoni, Paul A. Lyons, Joachim L. Schultze, Jörn Walter, Vibeke Andersen, SYSCID Consortium, Emmanouil T. Dermitzakis, Stefan Schreiber, Philip Rosenstiel
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background and aims Treatment with tumor necrosis factor α (TNFα) antagonists in IBD patients suffers from primary non-response rates of up to 40%. Biomarkers for early prediction of therapy success are missing. We investigated the dynamic
Externí odkaz:
https://doaj.org/article/533221e6756c4c1d84dece9aba5649b6
Autor:
Jerko Štambuk, Frano Vučković, Siniša Habazin, Maja Hanić, Mislav Novokmet, Susanna Nikolaus, Florian Tran, Stefan Schreiber, Andre Franke, Philip Rosenstiel, Gordan Lauc, Konrad Aden, Marija Pezer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8473 (2022)
Immunosuppressants and biologicals are widely used therapeutics for various chronic inflammatory diseases (CID). To gain more detailed insight into their downstream effects, we examined their impact on serum immunoglobulin G (IgG) glycosylation. We a
Externí odkaz:
https://doaj.org/article/f7a9888be8ba40d5abdb3d81b287f535
Autor:
Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek, Philipp Arnold, Katharina Knittler, Frederike Wilkens, Barbara Potempa, Björn Rabe, Marit Stirnberg, Ralph Lucius, Jörg W. Bartsch, Susanna Nikolaus, Maren Falk-Paulsen, Philip Rosenstiel, Marco Metzger, Stefan Rose-John, Jan Potempa, Gunnar C. Hansson, Peter J. Dempsey, Christoph Becker-Pauly
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2090-2103 (2017)
The host metalloprotease meprin β is required for mucin 2 (MUC2) cleavage, which drives intestinal mucus detachment and prevents bacterial overgrowth. To gain access to the cleavage site in MUC2, meprin β must be proteolytically shed from epithelia
Externí odkaz:
https://doaj.org/article/b24e999113e241ad82f86e3fbecdd8d3
Autor:
Sabine Siegert, Zhonghao Yu, Rui Wang-Sattler, Thomas Illig, Jerzy Adamski, Jochen Hampe, Susanna Nikolaus, Stefan Schreiber, Michael Krawczak, Michael Nothnagel, Ute Nöthlings
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76813 (2013)
BACKGROUND:To date, liver biopsy is the only means of reliable diagnosis for fatty liver disease (FLD). Owing to the inevitable biopsy-associated health risks, however, the development of valid noninvasive diagnostic tools for FLD is well warranted.
Externí odkaz:
https://doaj.org/article/a26b02b0f3854343bfe1b0befa5ee252
Autor:
Robert Häsler, Gunnar Jacobs, Andreas Till, Nils Grabe, Christian Cordes, Susanna Nikolaus, Kaiqin Lao, Stefan Schreiber, Philip Rosenstiel
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31151 (2012)
Micro-RNAs (miRNAs) are short, non-coding RNAs that regulate gene expression post transcriptionally. Several studies have demonstrated the relevance of miRNAs for a wide range of cellular mechanisms, however, the current knowledge on how miRNAs respo
Externí odkaz:
https://doaj.org/article/d107ed5633bb4f1a8b6b54ca04463fa9
Autor:
Christine M Costello, Nancy Mah, Robert Häsler, Philip Rosenstiel, Georg H Waetzig, Andreas Hahn, Tim Lu, Yesim Gurbuz, Susanna Nikolaus, Mario Albrecht, Jochen Hampe, Ralph Lucius, Günther Klöppel, Holger Eickhoff, Hans Lehrach, Thomas Lengauer, Stefan Schreiber
Publikováno v:
PLoS Medicine, Vol 2, Iss 8, p e199 (2005)
BACKGROUND: The differential pathophysiologic mechanisms that trigger and maintain the two forms of inflammatory bowel disease (IBD), Crohn disease (CD), and ulcerative colitis (UC) are only partially understood. cDNA microarrays can be used to decip
Externí odkaz:
https://doaj.org/article/8712308dac9b4671a2d2cea84a1cbdae
Autor:
Bram Verstockt, Valery Volk, Charlot Jaeckel, Dahham Alsoud, João Sabino, Susanna Nikolaus, An Outtier, Nicole Krönke, Friedrich Feuerhake, Gert De Hertogh, Philip Rosenstiel, Séverine Vermeire, Stefan Schreiber, Marc Ferrante, Konrad Aden
Publikováno v:
Alimentary Pharmacology & Therapeutics. 56:282-291
BACKGROUND: Tofacitinib is the first in class, pan-JAK inhibitor approved for ulcerative colitis (UC). Clinical efficacy has been shown, but long-term real-life endoscopic and histologic data are lacking. AIM: To investigate the effects of tofacitini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a82ddcdfe27c122948eb56708606c8
https://doi.org/10.1111/apt.16955
https://doi.org/10.1111/apt.16955
Autor:
Mark Ellrichmann, Rainer Noth, J Boesenkoetter, Konrad Aden, Johannes Bethge, Sebastian Zeissig, Susanna Nikolaus, T Bahmer, C Conrad, Stefan Schreiber
Publikováno v:
Journal of Crohn's & Colitis
Objective Increased mortality from respiratory diseases was observed in epidemiological studies of patients with ulcerative colitis [UC] as a potentially underestimated extraintestinal manifestation. We therefore investigated the presence of pulmonar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39963f3aae079cecfb3b285824c0da7e
https://doi.org/10.1093/ecco-jcc/jjab024
https://doi.org/10.1093/ecco-jcc/jjab024
Autor:
Huy Duc Le, Theresa Pflaum, Johannes Labrenz, Soner Sari, Fabienne Bretschneider, Florian Tran, Arne Lassen, Susanna Nikolaus, Silke Szymczak, Diana Kormilez, Philip Rosenstiel, Stefan Schreiber, Konrad Aden, Christoph Röcken
Publikováno v:
Journal of Crohn'scolitis.
Background Histological disease severity assessment in ulcerative colitis [UC] has become a mainstay in the definition of clinical endpoints [‘histological remission’] in clinical trials of UC. Several scores have been established in the microsco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4879aef677a6884d5bbca827badfe3
https://pubmed.ncbi.nlm.nih.gov/36282973
https://pubmed.ncbi.nlm.nih.gov/36282973