Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Susanna Nencetti"'
Autor:
Lidia Ciccone, Susanna Nencetti, Maria Marino, Chiara Battocchio, Giovanna Iucci, Iole Venditti, Martina Marsotto, Emiliano Montalesi, Simone Socci, Beatrice Bargagna, Elisabetta Orlandini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1812-1820 (2022)
Several epidemiological studies suggest that a diet rich in fruit and vegetables reduces the incidence of neurodegenerative diseases. Resveratrol (Res) and its dimethylated metabolite, pterostibene (Ptb), have been largely studied for their neuroprot
Externí odkaz:
https://doaj.org/article/37259ac13b5c41c187e07b8865097434
Autor:
Lidia Ciccone, Caterina Camodeca, Nicolò Tonali, Lucia Barlettani, Armando Rossello, Carole Fruchart Gaillard, Julia Kaffy, Giovanni Petrarolo, Concettina La Motta, Susanna Nencetti, Elisabetta Orlandini
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2369 (2023)
A series of new hybrid derivatives 1a–c, 2a–c, 3a–c, 4a–c, 5a–c, inspired by nature, were synthesized and studied as multifunctional agents for the treatment of Alzheimer’s disease (AD). These compounds were designed to merge together the
Externí odkaz:
https://doaj.org/article/9600a40359d640529d4c3d967198f601
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 1036 (2023)
Pomegranate fruit (PF) is a fruit rich in nutraceuticals. Nonedible parts of the fruit, especially peels, contain high amounts of bioactive components that have been largely used in traditional medicine, such as the Chinese, Unani, and Ayurvedic ones
Externí odkaz:
https://doaj.org/article/4d7b863fe6a243e4b28a97d592c1ed0b
Autor:
Doretta Cuffaro, Aleix Gimeno, Bianca Laura Bernardoni, Riccardo Di Leo, Gerard Pujadas, Santiago Garcia-Vallvé, Susanna Nencetti, Armando Rossello, Elisa Nuti
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11098 (2023)
Matrix metalloproteinase 13 plays a central role in osteoarthritis (OA), as its overexpression induces an excessive breakdown of collagen that results in an imbalance between collagen synthesis and degradation in the joint, leading to progressive art
Externí odkaz:
https://doaj.org/article/ec7eb482b6c344e585933e6d6e8cef33
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 12, Pp 2353-2358 (2021)
Neuroglobin (Ngb) is a 17 kDa monomeric hexa-coordinated heme protein belonging to the globin family. Ngb is mainly expressed in neurons of the central and peripheral nervous system, although moderate levels of Ngb have been detected in non-nervous t
Externí odkaz:
https://doaj.org/article/5f1f7ce76bdd4315ac0034225d47c1e5
Autor:
Alessio Nocentini, Doretta Cuffaro, Lidia Ciccone, Elisabetta Orlandini, Susanna Nencetti, Elisa Nuti, Armando Rossello, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 48-57 (2021)
The synthesis and carbonic anhydrase (CA; EC 4.2.1.1) activating effects of a series of oxime ether-based amino alcohols towards four human (h) CA isoforms expressed in human brain, hCA I, II, IV and VII, are described. Most investigated amino alcoho
Externí odkaz:
https://doaj.org/article/5e4b7f680e684ae183c6d9e3314fe9ca
Autor:
Susanna Nencetti, Doretta Cuffaro, Elisa Nuti, Lidia Ciccone, Armando Rossello, Marina Fabbi, Flavio Ballante, Gabriella Ortore, Grazia Carbotti, Francesco Campelli, Irene Banti, Rosaria Gangemi, Garland R. Marshall, Elisabetta Orlandini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 34-47 (2021)
Uveal melanoma (UM) represents an aggressive type of cancer and currently, there is no effective treatment for this metastatic disease. In the last years, histone deacetylase inhibitors (HDACIs) have been studied as a possible therapeutic treatment f
Externí odkaz:
https://doaj.org/article/dd29395ad7324c7e95f604e5f4b25f96
Autor:
Lidia Ciccone, Susanna Nencetti, Armando Rossello, Lucia Barlettani, Nicolò Tonali, Paola Nieri, Elisabetta Orlandini
Publikováno v:
Nutrients, Vol 15, Iss 3, p 749 (2023)
Eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6), two omega-3 poly-unsaturated fatty acids (PUFAs), are the main components in oil derived from fish and other marine organisms. EPA and DHA are commercially available as dietary s
Externí odkaz:
https://doaj.org/article/5e8723e1f8274b05a8e9d58dfa82cc64
Autor:
Emiliano Montalesi, Patrizio Cracco, Filippo Acconcia, Marco Fiocchetti, Giovanna Iucci, Chiara Battocchio, Elisabetta Orlandini, Lidia Ciccone, Susanna Nencetti, Maurizio Muzzi, Sandra Moreno, Iole Venditti, Maria Marino
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2148 (2023)
Breast cancer is the first leading tumor in women in terms of incidence worldwide. Seventy percent of cases are estrogen receptor (ER) α-positive. In these malignancies, 17β-estradiol (E2) via ERα increases the levels of neuroglobin (NGB), a compe
Externí odkaz:
https://doaj.org/article/7a3592d22a4840b7b444ab8c5ddd4004
Autor:
Felicia D'Andrea, Stefania Sartini, Ilaria Piano, Matteo Franceschi, Luca Quattrini, Lorenzo Guazzelli, Lidia Ciccone, Elisabetta Orlandini, Claudia Gargini, Concettina La Motta, Susanna Nencetti
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1194-1205 (2020)
Aldose reductase is a key enzyme in the development of long term diabetic complications and its inhibition represents a viable therapeutic solution for people affected by these pathologies. Therefore, the search for effective aldose reductase inhibit
Externí odkaz:
https://doaj.org/article/2b923e0da4124b2f977b2ce22fca760a