Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Susanna M.O. Hourani"'
Publikováno v:
European Journal of Neuroscience. 44:2446-2454
The key problem in treating cocaine addiction is the maintenance of a drug-free state as negative emotional symptoms during abstinence often trigger relapse. The mechanisms underpinning the emotional dysregulation during abstinence are currently not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f15f702cba56a834d1b6f02fb6876e
https://doi.org/10.1111/ejn.13348
https://doi.org/10.1111/ejn.13348
Autor:
Ian Kitchen, Polymnia Georgiou, Catherine Ledent, Panos Zanos, Ji Hoon J.H. Yoo, Susanna M.O. Hourani, Alexis Bailey, Sherie S.R. Wright, Raphaelle Winsky-Sommerer
Publikováno v:
Addiction Biology. 21:811-825
Addiction to psychostimulants is a major public health problem with no available treatment. Adenosine A2A receptors (A2A R) co-localize with metabotropic glutamate 5 receptors (mGlu5 R) in the striatum and functionally interact to modulate behaviours
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c366dea06d4170f24106ef90805351c8
https://doi.org/10.1111/adb.12259
https://doi.org/10.1111/adb.12259
Autor:
Alexis Bailey, Ian Kitchen, Panos Zanos, Mazdak Ehteramyan, Susanna M.O. Hourani, Polymnia Georgiou, Rafael Maldonado
Publikováno v:
Addiction Biology. 20:902-912
The key problem for the treatment of drug addiction is relapse to drug use after abstinence that can be triggered by drug-associated cues, re-exposure to the drug itself and stress. Understanding the neurobiological mechanisms underlying relapse is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbf200aef2aa444774ffe46ffb6838ae
https://doi.org/10.1111/adb.12208
https://doi.org/10.1111/adb.12208
Autor:
Susanna M.O. Hourani, Alexis Bailey, Sherie S.R. Wright, Catherine Ledent, Raphaelle Winsky-Sommerer, Polymnia Georgiou, Ji Hoon Yoo, Panos Zanos, Ian Kitchen
Publikováno v:
Pharmacology Biochemistry and Behavior. 119:72-79
There is mounting evidence that the neuropeptide oxytocin is a possible candidate for the treatment of drug addiction. Oxytocin was shown to reduce methamphetamine self-administration, conditioned place-preference, hyperactivity and reinstatement in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f4ba6d49aca7681ab5eb329e9c59d3
https://doi.org/10.1016/j.pbb.2013.05.009
https://doi.org/10.1016/j.pbb.2013.05.009
Autor:
Jolanta Opacka-Juffry, Ian Kitchen, Donald D. Fisher, Lisa L. Wells, Catherine Ledent, Susanna M.O. Hourani
Publikováno v:
Synapse. 66:383-390
Adenosine, acting on A(2A) adenosine receptors, regulates addictive processes induced by drugs of abuse. The present study investigates the role of A(2A) adenosine receptors in neurochemical and behavioural responses to an acute cocaine challenge. Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5833c40631ed72fdd387eaaab13b8828
https://doi.org/10.1002/syn.21527
https://doi.org/10.1002/syn.21527
Autor:
Lisa L. Wells, Rafael Maldonado, Anna Castañé, Olga Valverde, Ian Kitchen, Jolanta Opacka-Juffry, Catherine Ledent, Guadalupe Soria, Susanna M.O. Hourani
Publikováno v:
British Journal of Pharmacology. 155:757-766
Background and purpose. Purinergic system through the A2A adenosine receptor regulates addiction induced by different drugs of abuse. The aim of the present study was to investigate the specific role of A2A adenosine receptors in behavioral and neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f611c80742aa9db5fd238ff59e6c91a6
https://doi.org/10.1038/bjp.2008.299
https://doi.org/10.1038/bjp.2008.299
Autor:
Catherine Ledent, Martin Hussey, Susanna M.O. Hourani, Ian Kitchen, David Ribé, David Sawbridge, Sapna Thakur, Jian-Mei Li
Publikováno v:
Free Radical Biology and Medicine. 44:1433-1442
Cardiac tissues express constitutively an NADPH oxidase, which generates reactive oxygen species (ROS) and is involved in redox signaling. Myocardial metabolism generates abundant adenosine, which binds to its receptors and plays important roles in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4797238248e7b7a404b4bafb35932f1
https://doi.org/10.1016/j.freeradbiomed.2007.12.035
https://doi.org/10.1016/j.freeradbiomed.2007.12.035
Autor:
Yoshihiro Urade, S.R. Goldberg, Zhi-Li Huang, Sergi Ferré, Ian Kitchen, L. Yao, Ivan Diamond, Susanna M.O. Hourani
Publikováno v:
Progress in Neurobiology. 83:332-347
Adenosine A2A receptors localized in the dorsal striatum are considered as a new target for the development of antiparkinsonian drugs. Co-administration of A2A receptor antagonists has shown a significant improvement of the effects of L-DOPA. The pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73d87086fcf2ae6fe64a4e8eba70f570
https://doi.org/10.1016/j.pneurobio.2007.04.002
https://doi.org/10.1016/j.pneurobio.2007.04.002
Publikováno v:
Pain. 129:287-294
Adenosine is a neuromodulator with complex effects on pain pathways. Mice lacking the adenosine A2A receptor are hypoalgesic, and have altered analgesic responses to receptor-selective opioid agonists. These and other findings suggest a role for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf09336265116e3c21bf9766affbe55
https://doi.org/10.1016/j.pain.2006.10.014
https://doi.org/10.1016/j.pain.2006.10.014
Autor:
Ian Kitchen, Geoffrey D. Clarke, Susanna M.O. Hourani, Ian Bailey, Nick J. Toms, Lisa Godfrey
Publikováno v:
European Journal of Pharmacology. 562:68-71
Paracetamol is an effective analgesic but its mechanism of action is unclear. We investigated the effect of paracetamol and the analgesic adjuvant caffeine on the activity of NO synthase in mouse spinal cord and cerebellar slices in vitro, by measuri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa51e3f4fd50311c7bf9ffc4bfa1a2c1
https://doi.org/10.1016/j.ejphar.2007.01.075
https://doi.org/10.1016/j.ejphar.2007.01.075