Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Susanna M. Rybak"'
Publikováno v:
Current Pharmaceutical Biotechnology. 9:231-234
Ribonucleases (RNases) of the superfamily A exhibit potent antineoplastic activity yet do not mediate appreciable immunogenicity or non-specific toxicity in both animal models and cancer patients. Ranpirnase (Onconase), the first ribonuclease being e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1961aa2394d4ebebb811c2a0662ddd
https://doi.org/10.2174/138920108784567317
https://doi.org/10.2174/138920108784567317
Autor:
Susanna M. Rybak, King C. Chan, David A. Lucas, Dianne L. Newton, Haleem J. Issaq, Luke H. Stockwin, Josip Blonder, Maja A. Bumke, Thomas P. Conrads, Timothy D. Veenstra
Publikováno v:
Journal of Proteome Research. 5:2996-3007
Hypoxic conditions often persist within poorly vascularized tumors. At the cellular level constitutive activation of transcriptional regulators of the hypoxic response leads to the emergence of clones with aggressive phenotypes. The primary interface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b361c2226aa13081348dc8b2228dd03f
https://doi.org/10.1021/pr0601739
https://doi.org/10.1021/pr0601739
Publikováno v:
Journal of Immunotherapy. 28:245-251
To improve selective cytotoxicity and pharmacokinetics of an anti-CD22 antibody single chain Fv (scFv)-ribonuclease fusion protein, a dimeric derivative was generated. Human angiogenin was fused via a (G 4 S) 3 spacer peptide to the carboxy-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9e1de7dbd6bbb7ce5832886285f669
https://doi.org/10.1097/01.cji.0000161396.96582.10
https://doi.org/10.1097/01.cji.0000161396.96582.10
Publikováno v:
FEBS Letters. 578:257-261
By varying linker length and domain orientation three multivalent derivatives of a monovalent anti-CD22 single-chain fragment variable (scFv) antibody were generated. Shortening the linker of the V(H)-V(L) oriented scFv to 5 or 0 residues resulted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b73d91a9fc2ea7c8c8e5a12c509061b
https://doi.org/10.1016/j.febslet.2004.11.011
https://doi.org/10.1016/j.febslet.2004.11.011
Autor:
Barry Schweitzer, De Yang, Minjuan Wang, Joost J. Oppenheim, Helene F. Rosenberg, Stephen F. Kingsmore, O. M. Zack Howard, Qian Chen, Zhao Yuan Wang, Dianne L. Newton, Qin Fu, Velizar T. Tchernev, Susanna M. Rybak, Dhavalkumar D. Patel
Publikováno v:
The Journal of Immunology. 173:6134-6142
A number of mammalian antimicrobial proteins produced by neutrophils and cells of epithelial origin have chemotactic and activating effects on host cells, including cells of the immune system. Eosinophil granules contain an antimicrobial protein know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620bae697d3d57fdf2648d5d6f71a810
https://doi.org/10.4049/jimmunol.173.10.6134
https://doi.org/10.4049/jimmunol.173.10.6134
Autor:
Julie Richards, R Darbha, Dianne L. Newton, Bang K. Vu, Xinhua Ji, M. P. Deonarain, N S Courtenay-Luck, Juergen Krauss, Michaela A. E. Arndt, Susanna M. Rybak, Z Zhu, V Choudhry
Publikováno v:
British Journal of Cancer
Anti-MUC1 single-chain Fv (scFv) fragments generated from the humanised antibody huHMFG1 had adequate antigen-binding properties but very poor stability irrespective of the applied linker or domain orientation. Mutagenesis of heavy-chain framework re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28165432427a4c7a35f4ace546594fed
https://doi.org/10.1038/sj.bjc.6601759
https://doi.org/10.1038/sj.bjc.6601759
Autor:
Iñaki Sanz, Susanna M. Rybak, Fatim Cham, Xiaodong Xiao, Anil Choudhary, Thomas C. Evans, Mei-Yun Zhang, Peter Bouma, Gerald V. Quinnan, Yuuei Shu, Christopher C. Broder, Yan-Ru Feng, Sanjay Phogat, Dimiter S. Dimitrov
Publikováno v:
Journal of Immunological Methods. 283:17-25
Identification of broadly cross-reactive human monoclonal antibodies (mAbs) has major implications for development of vaccines, inhibitors and research tools. Here we describe a sequential antigen panning (SAP) methodology that may facilitate the sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725854f78af21a944b840aebbe4a546d
https://doi.org/10.1016/j.jim.2003.07.003
https://doi.org/10.1016/j.jim.2003.07.003
Autor:
Susanna M. Rybak, Michaela A. E. Arndt, Jürgen Krauss, Robert Schwarzenbacher, Shailen Greene, Bang K. Vu
Publikováno v:
International Journal of Cancer. 107:822-829
The generation of a single chain Fv (scFv) fragment derived from the anti-CD22 monoclonal antibody LL2 resulted in a molecule with good antigen binding but very poor stability properties, thus hampering its clinical applicability. Here we report on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42d95bd745c597d2080dfa09f8bbb55
https://doi.org/10.1002/ijc.11451
https://doi.org/10.1002/ijc.11451
Publikováno v:
Chemistry & Biology. 10:45-52
Bleomycin is a clinically used antitumor antibiotic long thought to function therapeutically at the level of DNA cleavage. Recently, it has become clear that bleomycin can also cleave selected members of all major classes of RNA. Using the computer p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace4c6d5f5ea0ec7e3321c53e8653b74
https://doi.org/10.1016/s1074-5521(02)00306-x
https://doi.org/10.1016/s1074-5521(02)00306-x
Publikováno v:
Journal of Molecular Biology. 317:119-130
The crystal structure of a post-translationally modified form of eosinophil-derived neurotoxin (EDN) with four extra residues on its N terminus ((−4)EDN) has been solved and refined at atomic resolution (1 A). Two of the extra residues can be place
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970029a79318acde6a0e1aabd21fec03
https://doi.org/10.1006/jmbi.2002.5406
https://doi.org/10.1006/jmbi.2002.5406