Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Susanna M. Hofmann"'
Autor:
Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J. Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M. Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kang, Gandhari Maity, Aaron Novikoff, Sebastian Parlee, Ekta Pathak, Sonja C. Schriever, Michael Sterr, Siegfried Ussar, Qian Zhang, Richard DiMarchi, Matthias H. Tschöp, Paul T. Pfluger, Jonathan D. Douros, Timo D. Müller
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101915- (2024)
Objective: The glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) signaling, but the underlying mechanisms remain largely unknown. Here, we assessed whether GIP regulates body weight and glucose c
Externí odkaz:
https://doaj.org/article/4df457ac59ce49e8af09680efdd590e2
Autor:
Stephan Sachs, Anna Götz, Brian Finan, Annette Feuchtinger, Richard D. DiMarchi, Yvonne Döring, Christian Weber, Matthias H. Tschöp, Timo D. Müller, Susanna M. Hofmann
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-8 (2023)
Abstract Background Agonism at the receptor for the glucose-dependent insulinotropic polypeptide (GIPR) is a key component of the novel unimolecular GIPR:GLP-1R co-agonists, which are among the most promising drugs in clinical development for the tre
Externí odkaz:
https://doaj.org/article/918aa466a89341c5b57ea0ddea449163
Autor:
Michaela Keuper, Lucia Berti, Bernhard Raedle, Stephan Sachs, Anja Böhm, Louise Fritsche, Andreas Fritsche, Hans-Ulrich Häring, Martin Hrabě de Angelis, Martin Jastroch, Susanna M. Hofmann, Harald Staiger
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 28-37 (2019)
Background/Objectives: Although the prevalence of obesity and its associated metabolic disorders is increasing in both sexes, the clinical phenotype differs between men and women, highlighting the need for individual treatment options. Mitochondrial
Externí odkaz:
https://doaj.org/article/673dd5d3e16b41cdb1c7cbe7b5227953
Autor:
Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D. Müller, Matthias H. Tschöp
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mi
Externí odkaz:
https://doaj.org/article/daba42e8bc934c15ab731e4faf7ff42c
Autor:
Simone Renner, Andreas Blutke, Britta Dobenecker, Georg Dhom, Timo D. Müller, Brian Finan, Christoffer Clemmensen, Maren Bernau, Istvan Novak, Birgit Rathkolb, Steffanie Senf, Susanne Zöls, Mirjam Roth, Anna Götz, Susanna M. Hofmann, Martin Hrabĕ de Angelis, Rüdiger Wanke, Ellen Kienzle, Armin M. Scholz, Richard DiMarchi, Mathias Ritzmann, Matthias H. Tschöp, Eckhard Wolf
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 180-190 (2018)
Objective: The worldwide prevalence of obesity has increased to 10% in men and 15% in women and is associated with severe comorbidities such as diabetes, cancer, and cardiovascular disease. Animal models of obesity are central to experimental studies
Externí odkaz:
https://doaj.org/article/d4b307cf77fc4936afcd250c904470f7
Autor:
Anna Götz, Maarit Lehti, Elizabeth Donelan, Cynthia Striese, Sebastian Cucuruz, Stephan Sachs, Chun-Xia Yi, Stephen C. Woods, Samuel D. Wright, Timo D. Müller, Matthias H. Tschöp, Yuanqing Gao, Susanna M. Hofmann
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1649-1659 (2018)
Meta-inflammation of hypothalamic areas governing energy homeostasis has recently emerged as a process of potential pathophysiological relevance for the development of obesity and its metabolic sequelae. The current model suggests that diet-induced n
Externí odkaz:
https://doaj.org/article/e48b521b49e04043b963b66df01ecbce
Autor:
Yuanqing Gao, Andrés Vidal-Itriago, Irina Milanova, Nikita L. Korpel, Martin J. Kalsbeek, Robby Zachariah Tom, Andries Kalsbeek, Susanna M. Hofmann, Chun-Xia Yi
Publikováno v:
Molecular Metabolism, Vol 7, Iss , Pp 155-160 (2018)
Objective: Leptin is a cytokine produced by adipose tissue that acts mainly on the hypothalamus to regulate appetite and energy homeostasis. Previous studies revealed that the leptin receptor is expressed not only in neurons, but also in glial cells.
Externí odkaz:
https://doaj.org/article/2e394c22479d46e49007fac6411a842f
Autor:
Michaela Keuper, Stephan Sachs, Ellen Walheim, Lucia Berti, Bernhard Raedle, Daniel Tews, Pamela Fischer-Posovszky, Martin Wabitsch, Martin Hrabě de Angelis, Gabi Kastenmüller, Matthias H. Tschöp, Martin Jastroch, Harald Staiger, Susanna M. Hofmann
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1226-1239 (2017)
Objective: Obesity-associated WAT inflammation is characterized by the accumulation and local activation of macrophages (MΦs), and recent data from mouse studies suggest that macrophages are modifiers of adipocyte energy metabolism and mitochondrial
Externí odkaz:
https://doaj.org/article/471836ca196740ea990d3ada27524382
Autor:
Yuanqing Gao, Andrés Vidal-Itriago, Martin J. Kalsbeek, Clarita Layritz, Cristina García-Cáceres, Robby Zachariah Tom, Thomas O. Eichmann, Frédéric M. Vaz, Riekelt H. Houtkooper, Nicole van der Wel, Arthur J. Verhoeven, Jie Yan, Andries Kalsbeek, Robert H. Eckel, Susanna M. Hofmann, Chun-Xia Yi
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3034-3042 (2017)
Consumption of a hypercaloric diet upregulates microglial innate immune reactivity along with a higher expression of lipoprotein lipase (Lpl) within the reactive microglia in the mouse brain. Here, we show that knockdown of the Lpl gene specifically
Externí odkaz:
https://doaj.org/article/278d3dbbc28e4d3894db4c7ece5dd2ca
Autor:
Sigrid Jall, Stephan Sachs, Christoffer Clemmensen, Brian Finan, Frauke Neff, Richard D. DiMarchi, Matthias H. Tschöp, Timo D. Müller, Susanna M. Hofmann
Publikováno v:
Molecular Metabolism, Vol 6, Iss 5, Pp 440-446 (2017)
Objective: Obesity is a major health threat that affects men and women equally. Despite this fact, weight-loss potential of pharmacotherapies is typically first evaluated in male mouse models of diet-induced obesity (DIO). To address this disparity w
Externí odkaz:
https://doaj.org/article/f1a6571116b44d4b90d3b371b21bbe35