Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Susanna Lewén"'
Autor:
Kareem L Graham, Jian V Zhang, Susanna Lewén, Thomas M Burke, Ton Dang, Maria Zoudilova, Raymond A Sobel, Eugene C Butcher, Brian A Zabel
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e112925 (2014)
Therapies that target leukocyte trafficking pathways can reduce disease activity and improve clinical outcomes in multiple sclerosis (MS). Experimental autoimmune encephalomyelitis (EAE) is a widely studied animal model that shares many clinical and
Externí odkaz:
https://doaj.org/article/c8b611f359684016999e0c9757613918
Autor:
Thomas M. Burke, Julia Gross, Kexin Huang, Eugene C. Butcher, Yayue Zheng, Cecilia Oderup, Alexander Scholz, Hua Tu, Brian A. Zabel, Jeffrey C. Carlson, Serina Huang, Jon C. Kosek, Nicole Salazar, Susanna Lewén, Michel Mittelbronn, Andrew D. Jang, Leona Nease
Publikováno v:
Molecular Therapy
Glioblastoma (GBM) is the least treatable type of brain tumor, afflicting over 15,000 people per year in the United States. Patients have a median survival of 16 months, and over 95% die within 5 years. The chemokine receptor ACKR3 is selectively exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f956344e885646d71faa7e7d421bccd
https://pubmed.ncbi.nlm.nih.gov/29606504
https://pubmed.ncbi.nlm.nih.gov/29606504
Autor:
Brian A. Zabel, Cecilia Oderup, Kexin Huang, Susanna Lewén, Hua Tu, Kathryn Wong, Thomas M. Burke, Melissa LaJevic
Publikováno v:
Journal of Immunological Methods. 413:69-73
Due to low numbers of endogenous dendritic cells (DCs) in vivo, exogenous DC-poietin Fms-like tyrosine kinase 3-ligand (FLT3L) is routinely used to generate DC for subsequent studies. We engineered a novel FLT3L-FC DNA construct that, when combined w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38277aed8bc44e3f5f71017deceb5895
https://doi.org/10.1016/j.jim.2014.07.008
https://doi.org/10.1016/j.jim.2014.07.008
Autor:
Hua Tu, Brian A. Zabel, J. Monnier, Kexin Huang, Eugene C. Butcher, Edward O'Hara, Susanna Lewén
Publikováno v:
The Journal of Immunology. 189:956-967
Chemokine (CC motif) receptor-like 2 (CCRL2) binds leukocyte chemoattractant chemerin and can regulate local levels of the attractant, but does not itself support cell migration. In this study, we show that CCRL2 and VCAM-1 are upregulated on culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ce16c6de33a9d79c79629c997d5843
https://doi.org/10.4049/jimmunol.1102871
https://doi.org/10.4049/jimmunol.1102871
Autor:
Marta E. Alarcón-Riquelme, Angelica M. Delgado-Vega, Sara E. Löfgren, Norberto Ortego-Centeno, Susanna Lewén, Sandra D'Alfonso, Bernardo A. Pons-Estel, Torsten Witte, Hong Yin, Sergey V. Kozyrev, Javier Martín, Elena Sánchez
Publikováno v:
The Journal of Rheumatology. 37:574-578
Objective.We examined the genetic association of the promoter insertion/deletion (indel) in IRF5 gene with systemic lupus erythematosus (SLE) in distinct populations and assessed its role in gene expression.Methods.Four IRF5 polymorphisms were genoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663af0c31e175cf6f6a9a0809634c9ba
https://doi.org/10.3899/jrheum.090440
https://doi.org/10.3899/jrheum.090440
Autor:
Thomas J. Schall, Yu Wang, Robert D. Berahovich, Susanna Lewén, Juan C. Jaen, Brian A. Zabel, Karen Ebsworth, Matthew J. Walters
Publikováno v:
Immunology. 141(1)
The concentration of CXCL12/SDF-1 in the bloodstream is tightly regulated, given its central role in leucocyte and stem/progenitor cell egress from bone marrow and recruitment to sites of inflammation or injury. The mechanism responsible for this reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd57c48f6261f8db695d23dce46b851
https://pubmed.ncbi.nlm.nih.gov/24116850
https://pubmed.ncbi.nlm.nih.gov/24116850
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 10, Iss 1, p 73 (2011)
Molecular Cancer, Vol 10, Iss 1, p 73 (2011)
Background Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4 and, for B cell-derived tumors, CXCR5. Expression of their respective chemokine lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa216b831421cf9c0c9459d946891465
https://doi.org/10.1186/1476-4598-10-73
https://doi.org/10.1186/1476-4598-10-73
Autor:
Zhenhua Miao, Igor I. Slukvin, Juan C. Jaen, Thomas J. Schall, Lin Gan, Robert D. Berahovich, Brian A. Zabel, Susanna Lewén, Kathleen E. McGrath, Jessica Dias, Jaime Pereda, Yu Wang, Mark E. T. Penfold
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 185(9)
Since the discovery that CXCR7 binds to CXCL12/SDF-1α, the role of CXCR7 in CXCL12-mediated biological processes has been under intensive scrutiny. However, there is no consensus in the literature on the expression of CXCR7 protein by peripheral blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e68f60a0dbef4e5dd17d6945bc7619
https://pubmed.ncbi.nlm.nih.gov/20889540
https://pubmed.ncbi.nlm.nih.gov/20889540
Autor:
Thomas J. Schall, Brian A. Zabel, Yu Wang, Zhenhua Miao, Juan C. Jaen, Susanna Lewén, Robert D. Berahovich, Nu L. Lai
Metastatic breast cancer is the leading cause of cancer-related death in women worldwide and, despite recent therapeutic advances, the disease remains incurable. A critical step in cancer cell metastasis is the degradation of extracellular matrix com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f263fd57acfbe622928ec91acdd89a
https://europepmc.org/articles/PMC3436257/
https://europepmc.org/articles/PMC3436257/
Autor:
Yu Wang, Zhenhua Miao, Brian A. Zabel, Thomas J. Schall, Anna Janowska-Wieczorek, Juan C. Jaen, Bretton Summers, Mark E. T. Penfold, Bin Zhao, Jay P. Powers, Robert D. Berahovich, Ali Jalili, Susanna Lewén, Penglie Zhang
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 183(5)
CXCR7 binds chemokines CXCL11 (I-TAC) and CXCL12 (SDF-1) but does not act as a classical chemoattractant receptor. Using CCX771, a novel small molecule with high affinity and selectivity for CXCR7, we found that, although CXCR7 is dispensable for “
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02aac3415138acc4bca02dcab3d2ab8a
https://pubmed.ncbi.nlm.nih.gov/19641136
https://pubmed.ncbi.nlm.nih.gov/19641136