Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Susanna L. Cooke"'
Autor:
Karen D. Howarth, Tashfina Mirza, Susanna L. Cooke, Suet-Feung Chin, Jessica C. Pole, Ernest Turro, Matthew D. Eldridge, Raquel Manzano Garcia, Oscar M. Rueda, Chris Boursnell, Jean E. Abraham, Carlos Caldas, Paul A. W. Edwards
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Background NRG1 gene fusions may be clinically actionable, since cancers carrying the fusion transcripts can be sensitive to tyrosine kinase inhibitors. The NRG1 gene encodes ligands for the HER2(ERBB2)-ERBB3 heterodimeric receptor tyrosine
Externí odkaz:
https://doaj.org/article/143f3c5b3d9649bca9f6f4162642d860
Autor:
Rebecca Caeser, Miriam Di Re, Joanna A. Krupka, Jie Gao, Maribel Lara-Chica, João M. L. Dias, Susanna L. Cooke, Rachel Fenner, Zelvera Usheva, Hendrik F. P. Runge, Philip A. Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S. Vassiliou, Brian J. P. Huntly, Annalisa Mupo, Rachael J. M. Bashford-Rogers, Daniel J. Hodson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
A dearth of adequate preclinical models to faithfully mimic diffuse large B-cell lymphoma has hampered the identification of driver genes. Here, the authors present a co-culture system that enables ex vivo expansion, viral transduction and transforma
Externí odkaz:
https://doaj.org/article/d3c9bc11a5cc4cb39c1c847ddd0e75b2
Autor:
Sam Behjati, Patrick S. Tarpey, Kerstin Haase, Hongtao Ye, Matthew D. Young, Ludmil B. Alexandrov, Sarah J. Farndon, Grace Collord, David C. Wedge, Inigo Martincorena, Susanna L. Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P. Butler, Jon W. Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P. Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M. Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profi
Externí odkaz:
https://doaj.org/article/4d580842711a47b9a0ba6bb379bd365f
Autor:
Sam Behjati, Gunes Gundem, David C. Wedge, Nicola D. Roberts, Patrick S. Tarpey, Susanna L. Cooke, Peter Van Loo, Ludmil B. Alexandrov, Manasa Ramakrishna, Helen Davies, Serena Nik-Zainal, Claire Hardy, Calli Latimer, Keiran M. Raine, Lucy Stebbings, Andy Menzies, David Jones, Rebecca Shepherd, Adam P. Butler, Jon W. Teague, Mette Jorgensen, Bhavisha Khatri, Nischalan Pillay, Adam Shlien, P. Andrew Futreal, Christophe Badie, ICGC Prostate Group, Ultan McDermott, G. Steven Bova, Andrea L. Richardson, Adrienne M. Flanagan, Michael R. Stratton, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with
Externí odkaz:
https://doaj.org/article/6591661632a94c5d9e36a5a48f8dcf2c
Autor:
Adam Shlien, Keiran Raine, Fabio Fuligni, Roland Arnold, Serena Nik-Zainal, Serge Dronov, Lira Mamanova, Andrej Rosic, Young Seok Ju, Susanna L. Cooke, Manasa Ramakrishna, Elli Papaemmanuil, Helen R. Davies, Patrick S. Tarpey, Peter Van Loo, David C. Wedge, David R. Jones, Sancha Martin, John Marshall, Elizabeth Anderson, Claire Hardy, Violetta Barbashina, Samuel A.J.R. Aparicio, Torill Sauer, Øystein Garred, Anne Vincent-Salomon, Odette Mariani, Sandrine Boyault, Aquila Fatima, Anita Langerød, Åke Borg, Gilles Thomas, Andrea L. Richardson, Anne-Lise Børresen-Dale, Kornelia Polyak, Michael R. Stratton, Peter J. Campbell
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 2032-2046 (2016)
Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise. To catalog the rules governing how somatic mutation exerts direct trans
Externí odkaz:
https://doaj.org/article/4492535398b04897a7bfaecb4a9c01d9
Autor:
Simon Crouch, Daniel Painter, Sharon L. Barrans, Eve Roman, Philip A. Beer, Susanna L. Cooke, Paul Glover, Suzan J.L. Van Hoppe, Nichola Webster, Stuart E. Lacy, Camilo Ruiz, Peter J. Campbell, Daniel J. Hodson, Russell Patmore, Cathy Burton, Alexandra Smith, Reuben M. Tooze
Publikováno v:
Blood Advances. 6:5716-5731
Follicular lymphoma (FL) is morphologically and clinically diverse, with mutations in epigenetic regulators alongside t(14;18) identified as disease-initiating events. Identification of additional mutational entities confirms this cancer’s heteroge
Autor:
Gwo Yaw, Ho, Elizabeth L, Kyran, Justin, Bedo, Matthew J, Wakefield, Darren P, Ennis, Hasan B, Mirza, Cassandra J, Vandenberg, Elizabeth, Lieschke, Andrew, Farrell, Anthony, Hadla, Ratana, Lim, Genevieve, Dall, James E, Vince, Ngee Kiat, Chua, Olga, Kondrashova, Rosanna, Upstill-Goddard, Ulla-Maja, Bailey, Suzanne, Dowson, Patricia, Roxburgh, Rosalind M, Glasspool, Gareth, Bryson, Andrew V, Biankin, Susanna L, Cooke, Gayanie, Ratnayake, Orla, McNally, Nadia, Traficante, Anna, DeFazio, S John, Weroha, David D, Bowtell, Iain A, McNeish, Anthony T, Papenfuss, Clare L, Scott, Holly E, Barker
Publikováno v:
Cancer Research. 82:4457-4473
Ovarian carcinosarcoma (OCS) is an aggressive and rare tumor type with limited treatment options. OCS is hypothesized to develop via the combination theory, with a single progenitor resulting in carcinomatous and sarcomatous components, or alternativ
Autor:
Iain A. McNeish, Andrew V. Biankin, David Millan, Sancha Martin, Philip Beer, Nafisa Wilkinson, Agata Kochman, Elizabeth Day, Sarah Bell, Naveena Singh, Rosalind M. Glasspool, Lynn Hirschowitz, James Paul, Mei Yen Chan, Suzanne Dowson, Lisa Evers, Darren Ennis, Susanna L. Cooke
A full list of mutations identified in SCC and MCT samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abfbf7e7b43fde3af8f1d5c581d9383
https://doi.org/10.1158/1078-0432.22463138.v1
https://doi.org/10.1158/1078-0432.22463138.v1
Autor:
Iain A. McNeish, Andrew V. Biankin, David Millan, Sancha Martin, Philip Beer, Nafisa Wilkinson, Agata Kochman, Elizabeth Day, Sarah Bell, Naveena Singh, Rosalind M. Glasspool, Lynn Hirschowitz, James Paul, Mei Yen Chan, Suzanne Dowson, Lisa Evers, Darren Ennis, Susanna L. Cooke
Kaplan Meier overall survival curves by PIK3CA, CDKN2A and TP53 allelic mutation state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d240b1ff3a1cd1e58a3da7b778e053e
https://doi.org/10.1158/1078-0432.22463159
https://doi.org/10.1158/1078-0432.22463159
Autor:
Iain A. McNeish, Andrew V. Biankin, David Millan, Sancha Martin, Philip Beer, Nafisa Wilkinson, Agata Kochman, Elizabeth Day, Sarah Bell, Naveena Singh, Rosalind M. Glasspool, Lynn Hirschowitz, James Paul, Mei Yen Chan, Suzanne Dowson, Lisa Evers, Darren Ennis, Susanna L. Cooke
Purpose: We sought to identify the genomic abnormalities in squamous cell carcinomas (SCC) arising in ovarian mature cystic teratoma (MCT), a rare gynecological malignancy of poor prognosis.Experimental design: We performed copy number, mutational st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c74226b420d122b79c4498d2f41a07
https://doi.org/10.1158/1078-0432.c.6525317
https://doi.org/10.1158/1078-0432.c.6525317