Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Susanna E. LeValley"'
Autor:
Michael J. Furniss, Susanna E. LeValley, Peter B. Madrid, Carol E. Green, Sunetra Ray, Joseph L. DeRisi, Linda L. Rausch, R. Kiplin Guy, Jon C. Mirsalis, Paul Catz, Lalitha V. Iyer
Among the known antimalarial drugs, chloroquine (CQ) and other 4-aminoquinolines have shown high potency and good bioavailability. Yet complications associated with drug resistance necessitate the discovery of effective new antimalarial agents. ADMET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c76d9f0e9729b7113c129c53ebabe93
https://europepmc.org/articles/PMC2866084/
https://europepmc.org/articles/PMC2866084/
Publikováno v:
Chemical Research in Toxicology. 3:551-558
The relation of various structural parameters to hepatotoxic potential was investigated by using six dinitrotoluene (DNT) isomers and isolated rat hepatocyte suspensions as the biological test system. DNT-induced hepatotoxicity was found to correlate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9469138da41cc7a1c84214339ca065b7
https://doi.org/10.1021/tx00018a010
https://doi.org/10.1021/tx00018a010
Autor:
James A. Crowell, Susanna E. LeValley, Carol E. Green, Yukihiko Hara, Robert Swezey, Daphne E Aldridge
Publikováno v:
International journal of toxicology. 22(3)
Polyphenols found in tea are potent antioxidants and have inhibitory activity against tumorigenicity. The purpose of the described study was to assess the absorption, tissue distribution, and elimination of epigallocatechin gallate (EGCG), the princi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1004d8ddf8c8ad1b6bd99178fb1ff0
https://pubmed.ncbi.nlm.nih.gov/12851151
https://pubmed.ncbi.nlm.nih.gov/12851151
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468458794
Naphthalene metabolism and toxicity have been extensively investigated and these data indicate that the lung and eye toxicity are mediated by reactive intermediates. The elegant studies conducted in Buckpitt’s laboratory implicate a 1,2-epoxide as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0338ec587f8ea2d1a11a3d8d14766fa
https://doi.org/10.1007/978-1-4684-5877-0_86
https://doi.org/10.1007/978-1-4684-5877-0_86
Autor:
Valorie Weizer, Jack E. Dabbs, Jay L. Webster, Susanna E. LeValley, Carol E. Green, Michael R. Abbott
Publikováno v:
Drug Metabolism and Pharmacokinetics. 9:208-209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07182a603058c060ae979b9ada572737
https://doi.org/10.2133/dmpk.9.supplement_208
https://doi.org/10.2133/dmpk.9.supplement_208
Publikováno v:
In Vitro. 18:945-951
Hepatocytes from livers of rats loaded by Fe-dextran treatment were isolated by an in situ collagenase perfusion technique and evaluated for their biochemical, cytochemical, and morphological characteristics in cell culture. Iron loads 15 times highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230618d3ce93f642b168830cc1198c77
https://doi.org/10.1007/bf02796351
https://doi.org/10.1007/bf02796351
Publikováno v:
Toxicology and Applied Pharmacology. 88:24-34
A coincubation system composed of hepatocytes in primary monolayer culture and erythrocytes suspended in the culture medium was developed and used as a model for investigations of mechanisms of cyanide antidote action at the cellular level. Hepatocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8425fb5aabf5f07b62568efefb94fb01
https://doi.org/10.1016/0041-008x(87)90266-3
https://doi.org/10.1016/0041-008x(87)90266-3
Publikováno v:
Archives of Biochemistry and Biophysics. 134:434-441
Pretreatment of the rat for 3 days with caffeine resulted in an elevation in the drugmetabolizing activity by the hepatic microsomal system. This effect is counteracted by the simultaneous administration of actinomycin D. Caffeine also shortened the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05ae870caeb56ff5c1549a54771f95
https://doi.org/10.1016/0003-9861(69)90303-8
https://doi.org/10.1016/0003-9861(69)90303-8
Publikováno v:
Life Sciences. 8:1123-1128
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb5929efbaebde7a85ff3e58d9d6f46
https://doi.org/10.1016/0024-3205(69)90166-0
https://doi.org/10.1016/0024-3205(69)90166-0
Publikováno v:
Journal of Medicinal Chemistry. 13:30-32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46e931125b4e750c39c5c938add7555
https://doi.org/10.1021/jm00295a008
https://doi.org/10.1021/jm00295a008