In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models

Autor: Caitlin M. Gillis, Macdonald Lynn, Friederike Jönsson, Andrew J. Murphy, Priscila P. Zenatti, Héloïse Beutier, Pierre Bruhns, Susanna Celli, David A. Mancardi, Philippe Bousso, Laurence Fiette

Publikováno v: Journal of Autoimmunity
Journal of Autoimmunity, 2017, 80, pp.95-102. ⟨10.1016/j.jaut.2016.09.009⟩
Journal of Autoimmunity, Elsevier, 2016, In Press, Corrected Proof ⟨10.1016/j.jaut.2016.09.009⟩

International audience; BACKGROUND:Anaphylaxis can proceed through distinct IgE- or IgG-dependent pathways, which have been investigated in various mouse models. We developed a novel mouse strain in which the human low-affinity IgG receptor locus, co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529b3169d2b9b5e00e4a698493822a77
https://doi.org/10.1016/j.jaut.2016.09.009

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

Autor: Béatrice Breart, Susanna Celli, David Michonneau, Pervinder Sagoo, Zacarias Garcia, Philippe Bousso

Publikováno v: Immunity
Immunity, 2016, CellPress, 44 (1), p143-154. ⟨10.1016/j.immuni.2015.12.008⟩
Immunity, Elsevier, 2016, CellPress, 44 (1), p143-154. ⟨10.1016/j.immuni.2015.12.008⟩

International audience; Allogeneic hematopoietic stem cell transplantation (allo-HSCT), a curative treatment for hematologic malignancies relies on donor cytotoxic T lymphocyte (CTL)-mediated graft-versus-leukemia (GVL) effect. Major complications of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb94e9b006dd5ed6d23bf3f2ddca851e
https://hal-pasteur.archives-ouvertes.fr/pasteur-01296510/document

Real-Time Manipulation of T Cell-Dendritic Cell Interactions In Vivo Reveals the Importance of Prolonged Contacts for CD4+ T Cell Activation

Autor: Fabrice Lemaître, Philippe Bousso, Susanna Celli

Publikováno v: Immunity
Immunity, Elsevier, 2007, 27 (4), pp.625-634. ⟨10.1016/j.immuni.2007.08.018⟩
Immunity, 2007, 27 (4), pp.625-634. ⟨10.1016/j.immuni.2007.08.018⟩

International audience; T cells interact with dendritic cells (DCs) for periods lasting from minutes to hours. However, a causal link between the duration of this interaction and the efficiency of T cell activation has not been established in vivo. E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e0ae0d6a9045725f9a138808cd2722
https://doi.org/10.1016/j.immuni.2007.08.018

The mechanism of anti-CD20–mediated B cell depletion revealed by intravital imaging

Autor: Jacques Deguine, Nico van Rooijen, Fabricio Montalvao, Philippe Bousso, Zacarias Garcia, Susanna Celli, Béatrice Breart

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 2013, 123 (12), pp.5098-5103. ⟨10.1172/JCI70972⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2013, 123 (12), pp.5098-5103. ⟨10.1172/JCI70972⟩
Montalvao, F, Garcia, Z, Celli, S, Breart, B, Deguine, J, van Rooijen, N & Bousso, P 2013, ' The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging ', Journal of Clinical Investigation, vol. 123, no. 12, pp. 5098-5103 . https://doi.org/10.1172/JCI70972
Journal of Clinical Investigation, 123(12), 5098-5103. The American Society for Clinical Investigation

International audience; Anti-CD20 Ab therapy has proven successful for treating B cell malignancies and a number of autoimmune diseases. However, how anti-CD20 Abs operate in vivo to mediate B cell depletion is not fully understood. In particular, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e505499e988d6050dbe060931377e5
https://hal-pasteur.archives-ouvertes.fr/pasteur-01410108/document

How many dendritic cells are required to initiate a T-cell response?

Autor: Philippe Bousso, Andreas Müller, Mark Day, Grant Lythe, Carmen Molina-París, Susanna Celli

Publikováno v: Blood
Blood, American Society of Hematology, 2012, 120 (19), pp.3945-3948. ⟨10.1182/blood-2012-01-408260⟩
Blood, 2012, 120 (19), pp.3945-3948. ⟨10.1182/blood-2012-01-408260⟩

T-cell activation in lymph nodes relies on encounters with antigen (Ag)–bearing dendritic cells (DCs) but the number of DCs required to initiate an immune response is unknown. Here we have used a combination of flow cytometry, 2-photon imaging, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8a2ec403b259e863eadb0ed8849b28
https://hal-pasteur.archives-ouvertes.fr/pasteur-03507378