Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Susanna Campesan"'
Autor:
Madeleine J. Twyning, Roberta Tufi, Thomas P. Gleeson, Kinga M. Kolodziej, Susanna Campesan, Ana Terriente-Felix, Lewis Collins, Federica De Lazzari, Flaviano Giorgini, Alexander J. Whitworth
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113681- (2024)
Summary: Mitochondrial calcium (Ca2+) uptake augments metabolic processes and buffers cytosolic Ca2+ levels; however, excessive mitochondrial Ca2+ can cause cell death. Disrupted mitochondrial function and Ca2+ homeostasis are linked to numerous neur
Externí odkaz:
https://doaj.org/article/9603e362758f41768755e35b7a1109b6
Autor:
Susanna Campesan, Ivana del Popolo, Kyriaki Marcou, Anna Straatman-Iwanowska, Mariaelena Repici, Kalina V. Boytcheva, Victoria E. Cotton, Natalie Allcock, Ezio Rosato, Charalambos P. Kyriacou, Flaviano Giorgini
Publikováno v:
Neurobiology of Disease, Vol 185, Iss , Pp 106236- (2023)
Huntington's disease (HD) is a fatal neurodegenerative disease with limited treatment options. Human and animal studies have suggested that metabolic and mitochondrial dysfunctions contribute to HD pathogenesis. Here, we use high-resolution respirome
Externí odkaz:
https://doaj.org/article/f244b257c55740d4955b65669107d32b
Autor:
Daniel C Maddison, Mónica Alfonso-Núñez, Aisha M Swaih, Carlo Breda, Susanna Campesan, Natalie Allcock, Anna Straatman-Iwanowska, Charalambos P Kyriacou, Flaviano Giorgini
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009129 (2020)
The enzyme kynurenine 3-monooxygenase (KMO) operates at a critical branch-point in the kynurenine pathway (KP), the major route of tryptophan metabolism. As the KP has been implicated in the pathogenesis of several human diseases, KMO and other enzym
Externí odkaz:
https://doaj.org/article/aea42986a97645b6b78125a87fbcc1a9
Autor:
Susan W Robinson, Julie-Myrtille Bourgognon, Jereme G Spiers, Carlo Breda, Susanna Campesan, Adrian Butcher, Giovanna R Mallucci, David Dinsdale, Nobuhiro Morone, Raj Mistry, Tim M Smith, Maria Guerra-Martin, R A John Challiss, Flaviano Giorgini, Joern R Steinert
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2003611 (2018)
Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation. Importantl
Externí odkaz:
https://doaj.org/article/9e9cf68bba724e81a075808600ab4057
Autor:
Laura, Delfino, Susanna, Campesan, Giorgio, Fedele, Edward W, Green, Flaviano, Giorgini, Charalambos P, Kyriacou, Ezio, Rosato
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2482
The clock neurons of the fruit fly Drosophila melanogaster have become a useful model for expressing misfolded protein aggregates that accumulate in several human neurodegenerative diseases. One advantage of such an approach is that the behavioral ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d25a0798c6bc3dc8ccdb496b3e98ff4
https://pubmed.ncbi.nlm.nih.gov/35610440
https://pubmed.ncbi.nlm.nih.gov/35610440
Autor:
Laura Delfino, Susanna Campesan, Giorgio Fedele, Edward W. Green, Flaviano Giorgini, Charalambos P. Kyriacou, Ezio Rosato
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622483
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43830397b448f816e13bed889e412d7b
https://doi.org/10.1007/978-1-0716-2249-0_25
https://doi.org/10.1007/978-1-0716-2249-0_25
Publikováno v:
Movement disorders 36(8), 1744-1758 (2021). doi:10.1002/mds.28605
Intracellular vesicular trafficking is essential for neuronal development, function, and homeostasis and serves to process, direct, and sort proteins, lipids, and other cargo throughout the cell. This intricate system of membrane trafficking between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174a93c41786ddafd79e4ed29cf4a7d4
https://pub.dzne.de/record/155579
https://pub.dzne.de/record/155579
Autor:
Flaviano Giorgini, Aisha M. Swaih, Anna Straatman-Iwanowska, Charalambos P. Kyriacou, Daniel C. Maddison, Mónica Alfonso-Núñez, Susanna Campesan, Natalie Allcock, Carlo Breda
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 11, p e1009129 (2020)
PLoS Genetics, Vol 16, Iss 11, p e1009129 (2020)
The enzyme kynurenine 3-monooxygenase (KMO) operates at a critical branch-point in the kynurenine pathway (KP), the major route of tryptophan metabolism. As the KP has been implicated in the pathogenesis of several human diseases, KMO and other enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd690b874d8039bfeb5a7717f001153
http://europepmc.org/articles/PMC7654755
http://europepmc.org/articles/PMC7654755
Autor:
Flaviano Giorgini, Lígia Fão, Luana Naia, Jorge Valero, Susanna Campesan, Carla Lopes, Victoria E. Cotton, Catarina Carmo, Tatiana R. Rosenstock, A. Cristina Rego
Publikováno v:
Free radical biologymedicine. 163
SIRT3 is a major regulator of mitochondrial acetylome. Here we show that SIRT3 is neuroprotective in Huntington's disease (HD), a motor neurodegenerative disorder caused by an abnormal expansion of polyglutamines in the huntingtin protein (HTT). Prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159ff370ad70a02671dea3f84aa51e64
https://pubmed.ncbi.nlm.nih.gov/33285261
https://pubmed.ncbi.nlm.nih.gov/33285261
Autor:
Susanna Campesan, Charalambos P. Kyriacou, Anna Straatman-Iwanowska, Victoria E. Cotton, Flaviano Giorgini, Kyriaki Marcou
Publikováno v:
Pathogenic mechanisms.
Background Metabolic dysfunction is a hallmark of HD pathology. Decreased glucose metabolism and increased lactate concentrations in HD brains suggest mitochondrial involvement in the disease. Moreover, alterations in mitochondrial fission/fusion bal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b10c821f68ed75e38b862168f8c2c3a6
https://doi.org/10.1136/jnnp-2018-ehdn.36
https://doi.org/10.1136/jnnp-2018-ehdn.36